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MB5-626 C5 4.0 Programming

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MB5-626 exam Dumps Source : C5 4.0 Programming

Test Code : MB5-626
Test denomination : C5 4.0 Programming
Vendor denomination : Microsoft
free pdf : 99 real Questions

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Microsoft Microsoft C5 4.0 Programming

journey an RDP assault? It’s your fault, now not Microsoft’s | killexams.com real Questions and Pass4sure dumps

I’ve seen blog posts and discussion board threads Dangerous mouthing Microsoft and faraway desktop Protocol (RDP). continually it’s along side a person complaining that a ransomware or cryptominer variant had correctly compromised their atmosphere via RDP. The rants are often followed by using calls for every person to dump Microsoft windows and the pass “Microsoft safety sucks!”

It’s now not only boring and pedantic. It’s a case of blaming the inaccurate perpetrator.

Let me be clear. if you're compromised because of RDP, the issue is you or your organization. It isn’t a problem with Microsoft or RDP. You don’t should consequence a VPN round RDP to protect it. You don’t deserve to alternate default network ports or some other black magic. simply consume the default protection settings or implement the myriad other protection defenses you'll want to acquire already been the consume of. if you’re getting hacked as a result of RDP, you’re no longer doing a bunch of issues that any first rate computer protection defender should soundless be doing.

Ransomware and RDP

there are lots of ransomware classes, like SamSam, and cryptominers, like CrySis, that worry brute-drive guessing assaults in opposition t accessible RDP capabilities. So many groups acquire had their RDP services compromised that the FBI and department of homeland security (DHS) acquire issued warnings.

The warning should be, “Your security sucks!” It isn’t like the malware classes are conducting a nil-day assail in opposition t some unpatched vulnerability. they're simply making a bare minimal of makes an attempt to find effortless-to-bet passwords on faraway entry bills, most of which appear to acquire admin-stage access.

If every bit of you did become acquire the defaults that Microsoft places in area, you can be very protected. That’s because by pass of default, Microsoft best makes it practicable for RDP for contributors of the built-in directors neighborhood (RID 501), which requires a password that could be sufficiently lengthy and complicated adequate to desist essential password guessing RDP attacks, specifically when paired with an account lockout policy that simplest allows a few incorrect guesses earlier than locking the account. When RDP malware breaks into a laptop you manipulate, that capacity you allowed the RDP-obtainable account to acquire a extremely frail password and didn’t acquire account lockout enabled.

I’m relatively certain that’s now not Microsoft’s fault.

most efficient practices to comfy RDP

if you ensue any of Microsoft’s a long time-long touted most desirable practices for safety RDP you could be doubly protected. for instance, Microsoft has long suggested that the default administrator denomination be renamed and gives a group policy election to permit that. It likewise recommends enabling the Interactive Logon: attain not monitor the remaining consumer denomination choice. If enabled, the password-guessing malware application would don't acquire any clue what username to start with to start a success guessing, and however it did, it could be conveniently stopped from guessing by pass of account lockout.

further, Microsoft recommends imposing the distribution and consume of trusted digital certificates to any computer making an attempt to logon to consume RDP. If the far off gadget doesn’t acquire the relied on digital certificates installed, it may well’t even start to pot on the logon password. The foremost laptop security practitioners even require multi-factor authentication (MFA), which RDP helps, as authentication credentials. Microsoft has been recommending and assisting these premiere practices for over a decade.

When RDP could definitely be an issue

there are times when having a faraway entry service can in reality add vulnerabilities to your gadget that you could not acquire trust of in opposition t the consume of the defaults or most efficient practices. a pretty qualified example of this would be when RDP (or a carrier reckoning on it) has a standard unpatched vulnerability. This happens, but it’s relatively infrequent. basically, as most advantageous as i attain know, it’s simplest took situation two or thrice in the multi-decade existence of RDP, which first regarded in home windows NT 4.0.

The closing faultfinding vulnerability in RDP changed into back in 2012. It become the real deal. It became remotely exploitable, and one malicious connection may acquire over the remote logon with not one a success authentication. Admins patched this one relatively speedy--quicker than the Dangerous guys and malware may acquire talents of it. on account that then, there has not been no longer a lone faultfinding vulnerability that might acquire expertise of RDP.  

Let’s examine that to OpenSSH (definitely the open supply competitor of RDP). It’s had 93 vulnerabilities considering the fact that 1999, including 9 within the ultimate two years. I don’t hear any one telling each person to dump Linux and BSD on account of OpenSSH vulnerabilities.

if you happen to attain more to protect RDP?

It can't harm to give protection to your publicly obtainable RDP connections with additional VPNs, altering default TCP/IP ports, and other protection strategies. Microsoft’s premiere apply advice of requiring digital certificates is to set up a precursor VPN, however you don’t deserve to attain it.

in case you ensure that you've got simple, example password policies together with account lockout enabled (even with a extreme quantity, like one hundred, of unhealthy logons authorized), you gained’t want the extra protections. There’s a lot to worry about and repair in the computing device world, and you don’t should add mitigations for those who’ve already mounted the rigor they decipher twice over.

i used to be a large believer in the usage of alternate ports, and even cooler, the usage of port knocking (where you ping a predetermined collection of ports, like a compund lock, before the firewall opens up the port you are looking to connect to), and different one-off defenses. You completely attain not need to attain them. They simply add unneeded complexity to an already secured device. 

If ransomware or a hacker effectively exploits your gadget or network because of RDP, you are doing many insecure, Dangerous things which are indictive of problems a long pass past simply RDP. The final thing i am going to attain is guilt Microsoft and RDP for a problem they don't seem to be even near creating--no more than i might guilt Linux and OpenSSL for password guessing considerations.


Microsoft Introduces enterprise able Licensing and trade competent Enhancement blueprint for Microsoft Dynamics | killexams.com real Questions and Pass4sure dumps

REDMOND, Wash. — July 10, 2006 — Microsoft Corp. nowadays introduced the company able Licensing mannequin and the company equipped Enhancement blueprint for Microsoft Dynamics™ that introduces simplifications and improvements in cost to the licensing and renovation classes for its Microsoft Dynamics enterprise management solutions.

business capable Licensing streamlines pricing for Microsoft Dynamics solutions — Microsoft Dynamics AX, Microsoft Dynamics GP, Microsoft Dynamics NAV and Microsoft Dynamics SL — by using poignant from a pricing mannequin based on lots of of modules and granules to a brand current mannequin based mostly primarily on the number of concurrent clients who in reality consume the application. This current model has three essential choices: Microsoft Dynamics trade necessities, Microsoft Dynamics superior management and Microsoft Dynamics superior administration business. they're based primarily on medium functionality and symbolize a cost discount for a customary entry-degree configuration, putting off lots of the complexity of licensing commercial enterprise useful resource planning software. Designed to enhance value for shoppers during the lifetime of their product answer, the current Enhancement blueprint represents a global maintenance program for Microsoft Dynamics options and introduces current merits such as transition investment credits, unlimited on-line working towards lessons for purchasers, and components to connect consumers with the Microsoft Dynamics community.

enterprise competent Licensing and Enhancement blueprint deliver customers with a compelling solution to boost the cost of their investments in Microsoft® expertise, lower the entry barrier to Microsoft Dynamics solutions, raise consumer productivity and evolve with the life of their business, featuring accelerated self-confidence in their alternative and enabling them to realize the entire skills of their Microsoft Dynamics answer.

“enterprise capable Licensing and Enhancement blueprint allow us to deliver more cost to their consumers while streamlining their choices,” talked about Tami Reller, company vice president of the enterprise options advertising group at Microsoft. “These current courses additional augment an business-main music record of delivering options for the people-in a position trade and their continued dedication to give companions and shoppers improved value and suppleness to fill their selected company needs.”

Maximizing the cost of investment in Microsoft technology

Microsoft Dynamics industry partners are excited in regards to the introduction of company capable Licensing because they will improvement via a discount in pre- and publish-revenue administrative efforts associated with the complexity of holding and selling varied product modules. it is going to allow them to drive higher earnings quantity via a limpid and simplified customer adventure.

“consumers wish less complexity and a licensing program it truly is standard and transparent and gives them extra value for their money,” mentioned Cornelis Bosch, vp of trade progress at To-raise, a Microsoft Dynamics industry companion. “enterprise equipped Licensing offers the confiscate stability between simplicity and flexibility through offering purchasers a really limpid and transparent pricing model that now not most effectual simplifies their buy resolution however additionally lowers the entry barrier for them to select the prerogative trade solution for their specific wants.”

clients will additionally odds from accelerated performance and simplicity offered by trade equipped Licensing through its current packaging that comprises here:

  • Microsoft Dynamics company necessities edition. This offering is an integrated, powerful economic and supply chain management solution that's designed for groups that need a core economic management and trade solution with a purpose to enable them to comfortably scale as their trade grows.

  • Microsoft Dynamics advanced administration edition. advanced administration version is the favorite solution for growing customers who need complicated, highly functional pecuniary and accounting programs and who are seeking for an adaptive solution to manage superior tactics for his or her financials, supply chain administration, manufacturing and mission accounting needs. It additionally helps them obtain the key enterprise intelligence and reporting required to manipulate their company.

  • Microsoft Dynamics advanced management enterprise. For organizations with complicated needs, superior administration commercial enterprise extends the advanced management edition by pass of presenting a flush set of superior deliver chain management, container carrier, configuration, manufacturing and progress capabilities on a flat-price basis.

  • moreover, Microsoft Dynamics CRM customer relationship management functionality will be included on the Microsoft trade options cost lists over the next one year, starting with Microsoft Dynamics GP.

    company in a position Licensing is concentrated on current customers. clients not licensed beneath trade ready Licensing nowadays could acquire the election to live on their existing licensing mannequin (modular-based licensing) or invent the transition to trade ready Licensing when it makes sustain for them.

    more desirable productivity and self belief in option

    the current Enhancement blueprint introduced today offers clients the value they are trying to find in their upkeep funding. This current blueprint is designed to ensure that valued clientele are assured of their alternative every step of the pass as they plan, deploy, use, preserve and upgrade their Microsoft Dynamics options. the current blueprint might be delivered globally to advocate consumers amass the most from their Microsoft Dynamics options and meet the altering needs of their company. moreover a set of worldwide constant merits and guidelines, Microsoft is providing current advantages to every bit of Microsoft Dynamics customers that are present on their protection plan:

  • limitless on-line practising merits. These current benefits may be obtainable for every bit of valued clientele enrolled in the Enhancement Plan, available globally:

  • E-classes. exact ideas on particular theme matter areas akin to product modules. knowledge obtained is akin to that presented in classrooms.

  • Courseware/training manuals. will likewise be used as a spy at device or a laptop reference.

  • Courseware extensions. Addenda available for chosen courseware titles, presenting content material on local performance within a given country.

  • “What’s New?” working towards manuals/courseware. training on the changes in aspects and performance between product versions.

  • researching plans. road maps that advocate people readily learn the practising they want and description each practising and certification alternative obtainable for each module.

  • Transition funding credit score. This current improvement for shoppers the usage of Microsoft Dynamics AX, Microsoft Dynamics GP, Microsoft Dynamics NAV and Microsoft Dynamics SL allows for consumers to commemorate 100 percent of their Microsoft Dynamics license investment towards the toddle from one Microsoft Dynamics product code basis to an additional or help from one package degree to a different (such as from universal to expert) inside a product family. This profit gives customers the additional self-confidence that their investment in Microsoft Dynamics will continue to be cozy as their enterprise needs evolve.

  • Microsoft Dynamics CustomerSource group and equipment. Microsoft Dynamics will prolong its award-profitable internet site to every bit of Microsoft Dynamics consumers globally who relate within the Enhancement Plan, with additional focus on localized content material and languages. CustomerSource presents product and service content material certain to the consumer’s account, a searchable skills base, downloads, discussion boards, on-line practising, information and different aspects, giving customers the tools they should amass extra from their Microsoft Dynamics solution.

  • Pricing and Availability

    company in a position Licensing blueprint is purchasable for Microsoft Dynamics GP, Microsoft Dynamics AX, Microsoft Dynamics NAV and Microsoft Dynamics SL and may be attainable to buy worldwide Aug. 1, 2006. The cost for Microsoft Dynamics enterprise essentials will rise at $2,250 (U.S.).*

    enterprise capable Enhancement blueprint is purchasable for Microsoft Dynamics GP, Microsoft Dynamics AX, Microsoft Dynamics NAV, Microsoft Dynamics SL and Microsoft C5. valued clientele will start to realize one of the vital merits of the brand current Enhancement blueprint with the unlock of enterprise competent Licensing — and should continue to spy the extra merits introduced over the subsequent six to nine months. additional information on trade in a position Licensing and Enhancement blueprint will likewise be discovered at http://www.microsoft.com/dynamics/purchase/pricing.mspx.

    About Microsoft Dynamics

    Microsoft Dynamics is a line of economic, consumer relationship and provide chain management solutions that helps businesses drudgery greater comfortably. Delivered via a community of channel partners presenting specialized functions, these built-in, adaptable trade administration options drudgery like and with customary Microsoft software to streamline procedures throughout a complete business.

    About Microsoft

    centered in 1975, Microsoft (Nasdaq “MSFT”) is the international leader in software, features and options that assist people and businesses recognise their complete talents.

    note to editors: in case you acquire an interest in viewing additional info on Microsoft, tickle consult with the Microsoft web page at http://www.microsoft.com/presspass on Microsoft’s company counsel pages. web hyperlinks, cellphone numbers and titles were amend at time of booklet, but may likewise when you deem that acquire modified. For further tips, journalists and analysts may likewise contact Microsoft’s rapid Response team or different applicable contacts listed at http://www.microsoft.com/presspass/contactpr.mspx.


    Microsoft proclaims Experimental release of ROS for windows 10 | killexams.com real Questions and Pass4sure dumps

    Microsoft ROS picture: Evan Ackerman/IEEE Spectrum

    Editor’s Picks

    Wizards of ROS: Willow garage and the Making of the robot working device

    Microsoft Shuts Down Its Robotics community

    arms-on With TurtleBot three, a powerful Little robot for studying ROS

    At ROSCon 2018 in Madrid this weekend, Microsoft showed up with a minute sales space and a TurtleBot 3. The TurtleBot wasn’t doing a noteworthy deal, just sitting on a table, nonetheless it was sitting on the desk while working ROS Melodic Morenia on windows 10. acquire been it launched onto the ground, it might acquire used its lidar to locate americans and drive towards them, as a proof of thought that Microsoft has correctly gotten ROS to drudgery in home windows.

    This isn’t just an remoted demo, both. In a blog submit, Lou Amadio (home windows IoT major utility engineer at Microsoft), says, “Microsoft is working with Open Robotics and the ROS Industrial Consortium to bring the robot operating device to home windows.” Hooray!

    one of the most largest boundaries to getting started with ROS is that it additionally includes getting every bit of started with Linux. for a lot of americans, this capability taking your chuffed and customary home windows computer, partitioning a difficult pressure, identifying a pass to deploy Linux from scratch, after which discovering a pass to consume it neatly adequate to set up ROS and open doing ROS things. I’ve been via this procedure, and it’s no longer principally pleasant. For particular person users, it will possibly now not be that large of a deal, but it may likewise be a greater gigantic impediment in academic environments.

    potentially, ROS on windows 10 would invent it less complicated for americans to amass going with ROS in a well-recognized environment. It’s no longer like this is a brand current theory, and we’ve considered a few diverse group-pushed initiatives that acquire attempted to invent ROS drudgery on windows earlier than, however during this case direct involvement and integration from Microsoft looks to be making the entire difference: “Microsoft will host the windows builds for ROS1 and shortly ROS2, as well as deliver documentation, building, and deployment solutions for windows. With ROS for home windows, developers might be capable of consume the accepted visual Studio toolset together with wealthy AI and cloud facets.”

    To amass ROS working on windows 10 at the moment, you’ll need a sixty four-bit edition of home windows 10 computing device (or home windows 10 IoT commercial enterprise), as a minimum 10 GB of space, and Microsoft visible Studio 2017 (the community version is free). then you’ll need to installation a outfit supervisor, install Git, install an administrator command line shortcut, and at eventual install ROS itself. It soundless looks a noteworthy deal, however Microsoft has constructive step-through-step instructions prerogative here. And from that factor, you’re free to start the simple ROS tutorials, even though it’s crucial to be sensible that there are some simple working device adjustments between windows and Linux that you just’ll need to be sensible about—as an example, Linux is case sensitive whereas windows isn't, and windows uses “\” the situation Linux makes consume of “/”, that sort of factor.

    It could be that Microsoft sees ROS as a desultory to invent its cloud platform, Azure, more attractive to roboticists, robotics companies, and industrial or industrial robotics deployments. Enthusiastic ROS advocate may differentiate Microsoft from Amazon’s AWS and Google Cloud Platform

    It’s too early to repeat just how a noteworthy deal Microsoft is committing to this, and we’re holding in humor that Microsoft’s recent background with robotics has been scattered at most advantageous. A decade ago, Microsoft appeared to be very positive about robotics, with bill Gates anticipating “a robotic in each home” in 2007. youngsters, altering priorities resulted within the dissolution of Microsoft’s robotics neighborhood in 2014. Microsoft nonetheless does some robotics research, however its robotics tasks are sprinkled across different analysis areas like synthetic intelligence, desktop imaginative and prescient, and human laptop interplay.

    So why does Microsoft need to assist ROS with home windows, and why the particular pastime presently? they can best speculate, however Lou Amadio’s weblog submit presents some hints:

    producers wish to invent robots greater sensible of their ecosystem, more convenient to application and safer to be around. Governments, producers, and teachers every bit of over the world are investing in the next era of manufacturing, every now and then known as “industry four.0”. 

    Microsoft has joined the ROS Industrial Consortium whose mission is to lengthen the superior capabilities of ROS to manufacturing and enhance the productivity and recrudesce on funding of industrial robots.

    We’re longing for bringing the clever district to robotics by bringing advanced aspects like hardware-accelerated windows machine learning, laptop vision, Azure Cognitive services, Azure IoT cloud services, and other Microsoft technologies to home, schooling, business, and industrial robots.

    reading between the traces prerogative here, it can be that Microsoft sees ROS as an opening to invent its cloud platform, Azure, extra appealing to roboticists, robotics corporations, and industrial or industrial robotics deployments. Enthusiastic ROS advocate may differentiate Microsoft from Amazon’s AWS and Google Cloud Platform, despite the fact Google has likewise made it limpid (here at ROSCon) that it’s actively attracted to ROS clients as smartly.

    whatever thing Microsoft’s motives are, it’s pleasing that they’ve taken steps toward making ROS (and soon ROS2) both greater attainable and more convenient to invent consume of. There’s a lot of scope for streamlining this pass even extra, besides the fact that children one of the vital simple changes between home windows and Linux could be difficult to reconcile. We’ll be watching intently to spy how things progress over the next a number of months, and we’ll be following up with each Microsoft and Open Robotics for (on-checklist) comments as quickly as they can.

    [ ROS for Windows ]


    MB5-626 C5 4.0 Programming

    Study lead Prepared by Killexams.com Microsoft Dumps Experts


    Killexams.com MB5-626 Dumps and real Questions

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    MB5-626 exam Dumps Source : C5 4.0 Programming

    Test Code : MB5-626
    Test denomination : C5 4.0 Programming
    Vendor denomination : Microsoft
    free pdf : 99 real Questions

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    Vermilion Energy plans 143 wells in Saskatchewan | killexams.com real questions and Pass4sure dumps

    Vermilion Energy Inc. has operations worldwide, but southeast Saskatchewan figures prominently in their plans for 2019.

    In Canada, Vermilion as has approved an exploration and progress budget of $319 million for 2019, representing a 23 per cent augment from its post-Spartan capital budget for 2018.

    article continues below

    “This will note their most vigorous capital program ever in Canada as they focus on their first complete year operating the former Spartan assets. They blueprint to drill or participate in 143 (129.0 net) light oil wells in Saskatchewan and 20 (17.7 net) wells in Alberta, including 19 (16.7 net) Mannville wells,” the company said in an Oct. 25 press release announcing its third quarter 2018 results.

    Vermilion’s third quarter 2018 production increased by 19 per cent from the prior quarter to 96,222 barrels of oil equivalent per day (boepd). The augment was primarily due to the complete quarter contribution from the Spartan acquisition and current production added from their 2018 drilling program.

    In Canada, production averaged 57,397 boepd in third quarter 2018, representing a 31 per cent augment from the previous quarter primarily due to the Spartan acquisition.

    Production was partially offset by downtime due to third party gas plant maintenance, rate restrictions on certain wells and weather-related project delays. Vermilion drilled or participated in 65 (59.0 net) wells and brought on production 53 (49.8 net) wells in third quarter 2018.

    The company successfully executed a five rig drilling program in Saskatchewan in the quarter, drilling or participating in 60 (54.6 net) wells across its combined land base. Vermilion likewise operated one rig in Alberta during the quarter which included the drilling of four (4.0 net) Mannville wells and one (0.4 net) Cardium well.

    Results from every bit of programs acquire been in line with the company’s expectations.

    Canadian oil differentials widened towards the desist of the quarter, which had a modestly negative impact on Vermilion’s realized pricing.

    “The majority of their Canadian liquids production receives significantly advantaged pricing relative to Alberta-based light raw oil. They acquire no ponderous raw (Western Canada Select) in their Canadian oil mix. Approximately 70 per cent of their Canadian oil is produced in southeast Saskatchewan and receives a cost referenced to LSB (Light acid Blend).

    “The remaining 30 per cent of their Canadian oil production is comprised of a combination of condensate and light oil in west-central Alberta and the Kerrobert district of Saskatchewan, which is cost referenced to the C5+ and MSW (Mixed Sweet Blend) benchmarks respectively. In the forward market for the balance of the year, the discount on every bit of Canadian oil products has widened significantly.

    “However, LSB and C5+ acquire widened to a much lesser extent than WCS and MSW. For example, LSB in the current prompt market has strengthened by approximately US$11.00 per barrel relative to MSW compared to the medium for Q3 2018,” the company said in the release.

    Although Vermilion does not actively target natural gas in their Canadian operations, it soundless produces gas from high margin condensate-rich and liquids-rich gas wells and associated gas from its light oil assets. Subsequent to the quarter, AECO gas prices acquire improved significantly, with the forward curve indicating a fourth quarter 2018 cost that is nearly double the third quarter 2018 price, representing a potential $1.00/metric cubic foot (mcf) quarter-over-quarter improvement should the forward curve be realized.

    For every $1.00/mcf augment in AECO gas prices, Vermilion estimates an additional annual FFO contribution of approximately $50 million.

    Vermilion’s board of directors has approved a 2019 capital budget of $530 million with associated production guidance of 101,000 to 106,000 boepd. The midpoint of this guidance scope represents year-over-year production growth of 18 per cent, or seven per cent on a per participate basis.


    Ra Pharmaceuticals Reports Third Quarter 2016 pecuniary Results and Provides Corporate Update | killexams.com real questions and Pass4sure dumps

    CAMBRIDGE, Mass.--(BUSINESS WIRE)--Ra Pharmaceuticals (NASDAQ:RARX), a clinical stage biopharmaceutical company focusing on the progress of next-generation therapeutics for diseases of complement dysregulation, today announced pecuniary results for the three months ended September 30, 2016 and provided an update on recent corporate and clinical developments.

    “Our successful initial public offering in October strengthened their balance sheet and allows us to initiate their aspect 2 clinical program evaluating their lead synthetic macrocyclic peptide candidate, RA101495, in paroxysmal nocturnal hemoglobinuria, or PNH, in the first quarter of 2017,” said Doug Treco, PhD, Founder and CEO of Ra Pharmaceuticals. “In addition, they spy forward to leveraging their drudgery in PNH and advancing RA101495 in other complement-mediated indications, including refractory generalized myasthenia gravis and lupus nephritis, as well as advancing their earlier stage complement inhibitors derived from their proprietary Extreme Diversity™ platform. I spy forward to providing future updates on their progress as they execute their clinical strategy.”

    Recent Developments

  • Completed a successful initial public offering that raised approximately $105.4 million in vulgar proceeds, including the complete exercise by the underwriters of their over-allotment option. Net proceeds to Ra Pharma, after deducting underwriting discounts and commissions and offering expenses, were approximately $95.7 million.
  • Announced that RA101495 has been granted Orphan Drug Designation by the European Commission for the treatment of PNH. This designation provides certain regulatory and pecuniary incentives for companies to develop and market therapies that treat a life-threatening or chronically debilitating condition affecting no more than five in 10,000 persons in the European Union, and for which no satisfactory treatment is available, or for which the product under consideration is expected to provide significant benefits to patients versus existing therapies.
  • Upcoming Milestones

  • In the first quarter of 2017, the Company expects to initiate its aspect 2 clinical crucible of RA101495 in PNH patients.
  • In the second half of 2017, the Company plans to initiate a aspect 2 clinical crucible of RA101495 in refractory generalized myasthenia gravis (rMG) and a aspect 1b clinical crucible in lupus nephritis (LN).
  • In the second half of 2017, the Company expects to report top-line data from its aspect 2 crucible of RA101495 in PNH.
  • Third Quarter 2016 pecuniary Results

    As of September 30, 2016, Ra Pharma reported total cash and equivalents of $31.2 million. Subsequent to the desist of the third quarter, the Company completed an initial public offering of common stock that raised total net proceeds of approximately $95.7 million, including overallotments.

    For the third quarter of 2016, Ra Pharma reported a net loss attributable to common shareholders of $8.1 million, or $14.22 per participate (basic and diluted), compared to $2.2 million, or $4.57 per share, for the same age in 2015.

    Research and progress expenses for the third quarter of 2016 were $7.1 million compared to $4.0 million for the same age in 2015. The augment was primarily due to pre-clinical and clinical progress costs associated with their lead program, RA101495, for the treatment of PNH.

    General and administrative expenses for the third quarter of 2016 were $1.0 million, compared to $0.5 million for the same age in 2015. The augment was due to employee-related costs, including salary, benefits and stock-based compensation due to the augment in G&A headcount to advocate the growth of the Company.

    Total revenue for the three months ended September 30, 2016 was $0 compared to $1.1 million for the same age in 2015. Revenue is comprised primarily of collaboration revenue from Merck. The decrease was due to the expiration of the research term of the Merck Agreement in April 2016.

    About RA101495

    Ra Pharma is developing RA101495 for paroxysmal nocturnal hemoglobinuria (PNH), refractory generalized myasthenia gravis (rMG), and lupus nephritis (LN). The product is designed for convenient, subcutaneous self-administration. RA101495 is a synthetic, macrocyclic peptide discovered using Ra’s Proprietary Extreme Diversity™ platform. The peptide binds complement C5 with subnanomolar affinity and allosterically inhibits its cleavage into C5a and C5b upon activation of the classical, alternative or lectin pathways. RA101495 likewise directly binds to C5b, disrupting the interaction between C5b and C6 and preventing assembly of the membrane assail involved (MAC). This activity defines an additional and novel mechanism for the inhibition of C5 function. Dosing of RA101495 was well tolerated in sound volunteers and demonstrated sustained and near complete suppression of hemolysis and complement activity.

    About the Extreme Diversity™ Platform

    Ra Pharma’s proprietary Extreme Diversity™ platform allows us to produce synthetic macrocyclic peptides that combine the diversity and specificity of antibodies with the pharmacological properties of minute molecules. They utilize a process called ‘‘mRNA display’’ to produce extremely large and diverse libraries of peptides from which to select potential product candidates. The platform generates highly specific and stable peptide-like molecules with the potential for greatly increased bioavailability, improved cell permeability, and the opening to address protein-protein interactions including previously undruggable targets. It can produce libraries of 10 to 100 trillion members, allowing for the rapid discovery of highly potent candidate molecules.

    About Ra Pharmaceuticals

    Ra Pharmaceuticals is a clinical stage biopharmaceutical company focusing on the progress of next-generation therapeutics for diseases of complement dysregulation and other orphan indications. The Company discovers and develops peptides and minute molecules to target key components of the complement cascade. For more information, tickle visit: www.rapharma.com.

    Forward Looking Statement

    This press release contains "forward-looking statements" within the acceptation of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the safety, efficacy and regulatory and clinical progress of their product candidates, including RA101495. every bit of such forward-looking statements are based on management's current expectations of future events and are theme to a number of risks and uncertainties that could antecedent actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties comprehend the risks that Ra Pharma’s product candidates, including RA101495, will not successfully be developed or commercialized; as well as the other factors discussed in the “Risk Factors” and "Management's Discussion and Analysis of pecuniary Condition and Results of Operations" sections in Ra Pharma’s Registration Statement on form S-1 (File No. 333-214242), as amended, which is on file with the Securities and Exchange Commission and was declared effectual on October 25, 2016, as well as other risks detailed in Ra Pharma’s subsequent filings with the Securities and Exchange Commission. There can be no assurance that the actual results or developments anticipated by Ra Pharma will be realized or, even if substantially realized, that they will acquire the expected consequences to, or effects on, Ra Pharma. every bit of information in this press release is as of the date of the release, and Ra Pharma undertakes no duty to update this information unless required by law.

      Ra Pharmaceuticals, Inc. Condensed Consolidated balance Sheets (Unaudited) (In thousands)           September 30, December 31, 2016 2015   Assets Cash and cash equivalents $ 31,196 $ 19,386 Prepaid expenses and other current assets 669 800 Property and equipment, net 5,673 2,143 Other assets, noncurrent   3,110     2,013   Total assets $ 40,648   $ 24,342     Liabilities and stockholders’ deficit Accounts payable and accrued expenses $ 5,510 $ 2,593 Total deferred revenue - 1,862 Other liabilities, current 219 2,724 Other liabilities, noncurrent 2,981 687 Redeemable convertible preferred stock 86,483 53,675 Stockholder's deficit   (54,545 )   (37,199 ) Total liabilities and stockholders’ deficit $ 40,648   $ 24,342       Ra Pharmaceuticals, Inc. Condensed Consolidated Statements of Operations (Unaudited) (In thousands, except per participate data)                   Three Months Ended Nine Months Ended September 30, September 30, 2016 2015 2016 2015   Revenues $ -   $ 1,096   $ 4,928   $ 3,273   Operating expenses Research and development 7,079 4,027 18,541 10,593 General and administrative   1,042     539     3,418     1,549   Total operating expenses   8,121     4,566     21,959     12,142   Loss from operations   (8,121 )   (3,470 )   (17,031 )   (8,869 ) Other expense, net   7     (462 )   (945 )   (511 ) Net loss $ (8,114 ) $ (3,932 )

    $

    (17,976

    )

    $ (9,380 ) Gain on extinguishment of redeemable convertible preferred shares   -     1,673     -     1,673   Net loss attributable to common shareholders $ (8,114 ) $ (2,259 )

    $

    (17,976

    )

    $ (7,707 ) Net loss per share-basic and diluted $ (14.22 ) $ (4.57 ) $ (32.73 ) $ (15.84 ) Weighted-average number of common shares used in net loss per share applicable to common stockholders-basic and diluted   570,558     494,302     549,138     486,479    

    Algorithm of the Week: Generate Music Algorithmically | killexams.com real questions and Pass4sure dumps

    What is a Markov Chain?

    The algorithm of the week is a Markov Chain. Using this technique you leverage a Little bit of probability to attain some light machine learning. In this case, input a song and acquire the computer create an original drudgery based off the patterns you’ve taught it.

    I’ve attached a sample song. Give it a listen. I deem you’ll be by a long shot surprised that that’s a completely computer generated song. Only somewhat… it’s not very good, but it definitely isn’t predictable and yet isn’t racket either.

    Click here to open the example as a .wav file

    How’d You attain That?!

    There’s a fairly simple computer science technique known as a “Markov Chain”. Don’t let the entire reference to computer science fool you, it’s really not tough to grasp. Basically I created a table of numbers that answers the following question: When note X was played what percentage of the time were the other notes played next? So just imagine a table with every bit of of the notes from a to g# laid out on top (these are the notes that they eventual played) and plumb axis is every bit of of the same notes but this axis represents the probability that that particular note was played next.

    Here’s a sample of what my program generates:   

    a a# b c c# d d# e f f# g g# a [[0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], a# [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], b [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], c [0, 0, 0, 6, 0, 1, 0, 0, 0, 0, 2, 0], c# [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], d [0, 0, 0, 1, 0, 0, 0, 2, 0, 0, 0, 0], d# [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], e [0, 0, 0, 1, 0, 2, 0, 3, 1, 0, 0, 0], e# [0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0], f [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], f# [0, 0, 0, 1, 0, 0, 0, 1, 1, 0, 2, 0], g [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0], g# [0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0]]

    This is called an “adjancency list”. I’ve populated it with the music to Twinkle Twinkle. Let’s reply a question using it. How often does playing a C note lead to us playing another C note?

    First they spy up C on the left column and ensue the row to the column labeled C. They amass the reply 6. In order to device out how often they play C given that they just played C though they need to know how many times they played a C note first. Adding up every bit of of the values in the row gets us 9. So 6/9’s of the time (or 2/3) playing a C note will lead to us playing another C note.

    Here’s the timings table (1, 1/2, 1/4, 1/8, 1/16 notes): 

    1 2 4 8 16 1 [0, 0, 0, 0, 0], 2 [0, 0, 0, 1, 0], 4 [0, 0, 3, 5, 0], 8 [0, 2, 4, 11, 0], 16 [0, 0, 0, 0, 0]

    But that’s it, that’s the magic that drives the entire process. As you can see, I’m actually not storing percentages but instead just the import of the number of times a note led to a different note. It works out to be the same thing in the end.

    Code

    Of course they need to survey some code! As usual, I’ll start with the highest level and drill into it in more detail.

    This portion of the code records the notes for “Twinkle, Twinkle” into the music learner I create. Then I repeat it to give me 100 notes based on what it’s learned:

    class MusicMatrix: def __init__(self): self._previous_note = None self._markov = MarkovBuilder(["a", "a#", "b", "c", "c#", "d", "d#", "e", "f", "f#", "g", "g#"]) self._timings = MarkovBuilder([1, 2, 4, 8, 16]) def add(self, to_note): """Add a path from a note to another note. Re-adding a path between notes will augment the associated weight.""" if(self._previous_note is None): self._previous_note = to_note return from_note = self._previous_note self._markov.add(from_note[0], to_note[0]) self._timings.add(from_note[1], to_note[1]) self._previous_note = to_note def next_note(self, from_note): recrudesce [self._markov.next_value(from_note[0]), self._timings.next_value(from_note[1])] # Playing it comes next :) #test = [['c',4], ['e',4], ['g',4], ['c5',1]] #pysynth.make_wav(test, fn = "test.wav") musicLearner = MusicMatrix() # Input the melody of Row, Row, Row Your Boat # The MusicMatrix will automatically consume this to # model their own song after it. musicLearner.add(["c", 4]) musicLearner.add(["c", 4]) musicLearner.add(["c", 4]) musicLearner.add(["d", 8]) musicLearner.add(["e", 4]) musicLearner.add(["e", 4]) musicLearner.add(["d", 8]) musicLearner.add(["e", 4]) musicLearner.add(["f", 8]) musicLearner.add(["g", 2]) musicLearner.add(["c", 8]) musicLearner.add(["c", 8]) musicLearner.add(["c", 8]) musicLearner.add(["g", 8]) musicLearner.add(["g", 8]) musicLearner.add(["g", 8]) musicLearner.add(["e", 8]) musicLearner.add(["e", 8]) musicLearner.add(["e", 8]) musicLearner.add(["c", 8]) musicLearner.add(["c", 8]) musicLearner.add(["c", 8]) musicLearner.add(["g", 4]) musicLearner.add(["f", 8]) musicLearner.add(["e", 4]) musicLearner.add(["d", 8]) musicLearner.add(["c", 2]) random_score = [] current_note = ["c", 4] for i in range(0,100): print current_note[0] + ", " + str(current_note[1]) current_note = musicLearner.next_note(current_note) random_score.append(current_note) pysynth.make_wav(random_score, fn = "first_score.wav")

    The MarkovBuilder is where the algorithm is hiding. Notice how the MusicMatrix is keeping track of the previous note for us? The MarkovBuilder needs to be told explicitly which notes connect to which.

    import random class MarkovBuilder: def __init__(self, value_list): self._values_added = 0 self._reverse_value_lookup = value_list self._value_lookup = {} for i in range(0, len(value_list)): self._value_lookup[value_list[i]] = i # Initialize their adjacency matrix with the initial # probabilities for note transitions. self._matrix=[[0 for x in range(0,len(value_list))] for i in range(0,len(value_list))] def add(self, from_value, to_value): """Add a path from a note to another note. Re-adding a path between notes will augment the associated weight.""" value = self._value_lookup self._matrix[value[from_value]][value[to_value]] += 1 self._values_added = self._values_added + 1 def next_value(self, from_value): value = self._value_lookup[from_value] value_counts = self._matrix[value] value_index = self.randomly_choose(value_counts) if(value_index < 0): raise RuntimeError, "Non-existent value selected." else: recrudesce self._reverse_value_lookup[value_index] def randomly_choose(self, choice_counts): """Given an array of counts, returns the index that was randomly chosen""" counted_sum = 0 count_sum = sum(choice_counts) selected_count = random.randrange(1, count_sum + 1) for index in range(0, len(choice_counts)): counted_sum += choice_counts[index] if(counted_sum >= selected_count): recrudesce index raise RuntimeError, "Impossible value selection made. BAD!"

    Again this class’s sole intuition to exist is to track how one value they give it leads to another, and it facilitates picking values to give us that are informed by what has happened in the past. It’s distinguished to note that they don’t just pick the value that occurred the most. If they did that it would invent their program much less interesting. Instead they consume the “randomly_choose” role to elect a next value in a weighted manner (very similar to Bayes Theorem for those of you wondering).

    Grok’d

    So to summarize, my program was able to generate the music because I fed it a sample musical score and it figured out what percentage of the time a c note led to another note. Here’s a step by step sprint through:

  • Give program a note and a timing. - When I give it a second note/timing it notes in it’s table that the first note led to the 2nd note one time. It likewise notes that the first timing led to this 2nd timing one time. (note I don’t attempt to relate notes/timings, it’s not distinguished surprisingly).
  • Enter a third note. - The program then notes in its table that the 2nd note led to the 3rd note one time. - Continue ad inifinitum So that’s how they set the system up. Next this is how they amass the program to Come up with its own song:
  • Choose some random note/timing to start. - examine the computer to imply what a qualified note/timing would be to ensue those. - print out the note/timing (in case it’s a drudgery of genius ;)
  • play each note using the python library I’m using, pysynth.
  • Here’s a link to my git repo with every bit of of my Python code: http://github.com/jcbozonier/MarkovMusic/tree/master

    That’s every bit of for now!

    Disclaimer: The opinions expressed here delineate my own and not those of my employer.



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