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650-575 LCSAS Cisco Lifecycle Services Advanced Security

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650-575 exam Dumps Source : LCSAS Cisco Lifecycle Services Advanced Security

Test Code : 650-575
Test cognomen : LCSAS Cisco Lifecycle Services Advanced Security
Vendor cognomen : Cisco
free pdf : 178 real Questions

LCSAS Cisco Lifecycle Services

How 3M and Cisco exhaust "expertise systems" to inspire Innovation | killexams.com real Questions and Pass4sure dumps

As an advisor and consultant to some of the world's biggest and most creative corporations, during the last few years I've seen a histrionic shift within the C-Suite.

today's executives recognize the urgency to ascertain and do money into disruptive technology. whether it's blockchain, self reliant cars or the web of things, the frenzy makes feel. Strategic innovators scan with expertise. Investing time and money in something unproven is expense the chance. if you don't disrupt, they say, you'll finally live disrupted.

I've had the privilege to finish a runt travail with two massive businesses universal for his or her long-term center of attention and investments in innovation - 3M and Cisco. relish many organizations, they follow disruptive applied sciences to construct their future products and functions.  however 3M and Cisco besides exhaust a similar approach to their know-how-inspired innovation to achieve it a sustainable and repeatable technique. here's how the they finish it:

explore the Disrupters, however finish not stop There

3M recently established an initiative on "linked Roads" to tap into the approaching disruption from self sufficient vehicles.  3M's scientists are developing current materials for street signals so sensors on automatic motors can music signals as they velocity by route of, practically enabling both people and machines to navigate roadways together in a genuine route by "studying" the same indications.

Cisco applied the vitality of the information superhighway of issues through the exhaust of data from lots of related instruments to create what it calls "intent-based mostly networking" - aggregating big amounts of records promises to ultimately display a current flush of synthetic intelligence.

no matter if these experiments develop into the subsequent substantial component for 3M and Cisco is any person's wager. that's because the biggest challenge with step forward innovation is that the market success of any given product or carrier according to current expertise is totally unpredictable.

for most businesses, the query is never even if to scan, but kindhearted of a route to continually create current profits streams over time. long-term innovators relish 3M and Cisco esteem that in today's world enamored by route of the allure of disruptive expertise, it live essential to investigate the expertise online game changers, whereas no longer become blinded by route of them. bound, a big innovation might besides near from a current to the realm know-how, but leveraging existing technical capabilities is equally essential, if no longer a impartial greater predictable driver of sustainable enterprise increase.

Use expertise systems to pressure lengthy-term boom

notwithstanding they're in fully different industries, 3M and Cisco both exhaust "expertise platforms" to e-book their innovation efforts. These groups admire they want a system to cheer innovation that enormously improves upon state-of-the-art offerings or creates totally current market opportunities - although these innovations aren't always "disruptive" per se.

A "platform" is a technology that will besides live used as the basis for growing various items or services.  one among 3M's most eminent know-how systems is "adhesives," which has allowed the company to create products relish submit-It Notes, super Sticky Easel Pads, Scotch tape, stretch free up Command strips, efficiency adhesives to exchange rivets on airplanes, scientific tape, and the listing goes on.

The issue in most groups is that leadership either only goes for the big bets or gets caught in a single-minded focal point on the diminutive stuff. If they simplest rock for the fences, we'll omit the casual to rating on singles, doubles, or triples as smartly. technology platforms supply a means to ranking on quite a lot of forms of improvements that champion win the lengthy online game.

outline Your structures

Most companies deem the theory of "core knowledge" - the combination of abilities, supplies, and strengths that aid differentiate an organization in the marketplace. while technology might contribute to a company's ordinary core advantage, expertise systems are a a lot more selected option to Take into account and Take knowledge of know-how to power innovation.

3M, as an instance, makes exhaust of a "periodic table" structure to classify 46 technology platforms into four areas that focal point its innovation efforts: substances, tactics, capabilities, and purposes. in accordance with Gayle Schueller, 3M's vp of recent structures, "3M's expertise systems champion lead efforts to sustain world-category capabilities and differentiated capabilities that develop selected products, services, methods, and enterprise fashions."

Cisco applies a special strategy to defining its platforms, though the influence is similar. Cisco's features business structures some of its innovation platforms in keeping with what's necessary to carry services for open supply software. The thought is basic. based on Stan Baginskis, Cisco services Sr. Director of expertise strategy and boom, "Accelerated adoption of open supply utility creates a casual to supply functions to aid their consumers exhaust the application to its complete talents."

To the layperson, open source application may live almost unparalleled (like FD.io, OpenDaylight, and so forth.), however many of these gear stand eddy into the technical backbones that assist rush the networks, safety, storage, and cloud capabilities of many big corporations. because the application is open supply, the software itself is free, however businesses are left to their own contraptions to invoke it.

Cisco makes exhaust of a simple framework to portray its structures, each of which is a step in the life cycle of how agencies select, customize, enforce, and champion their utility tools. as an instance, Cisco views its platforms as Advisory, Implementation, development, Technical aid, retort Validation, and Optimization. each and every of those structures comprise quite a lot of provider offerings that assist clients benefit from their utility.

Make platforms Strategic

no longer every technology is a platform for every enterprise.  Some applied sciences can live valuable for constructing specific items, but they may besides not live the groundwork for future aggressive expertise via innovation. 3M, as an example, makes exhaust of paper in items relish do up-It notes and easel pads. but 3M sources paper from many suppliers, so the company doesn't view it as a core expertise platform. Any business can purchase bulk paper to achieve exhaust of in their products, which is why it live now not commonly seen as a differentiator when it involves innovation. due to this fact, 3M makes a speciality of platforms it could ply and follow to current products in methods that almost total rivals can not.

in a similar fashion, Cisco is rarely making an attempt to write down code to advance every open supply software device. quite, Cisco looks at the particular software where valued clientele stand the greatest need and Cisco has the most expertise to offer. as an instance, of the dozens of open supply utility tools accessible, some are greater susceptible to security breaches than others. Cisco focuses on constructing out its safety consulting features specially geared to consumers the usage of the utility that may most benefit from extra protection aid, pretty much defining its platform (e.g., protection implementation) on the subject of a given open supply tool.

expertise systems serve as the groundwork for product and service innovation, and the best structures aid create market differentiation.

strengthen platforms with clients

know-how is barely technology except it solves a consumer issue. In trendy world focused on design pondering, the customer experience, and customer centricity, it may well judge counter-intuitive to center of attention on know-how-driven innovation. but the foremost know-how systems naturally contour the consumer advantages or problems that they could champion handle, so that they're related to what basically adds value to the market.

Cisco, as an example, started working with an vast US wireless communications tremendous to assist the business optimize an open source records analytics appliance referred to as PNDA (pronounced "Panda"). a lot of records passes during the carrier issuer's community every day in the shape of calls, texts, movies, augmented and digital fact games, and other cell web site visitors.  PNDA helps businesses collect, seize, and dissect this facts whereas growing visual stories for what's occurring across the network. whereas the PNDA open supply utility is tremendous for knowing what's presently occurring, by using itself it doesn't deliver prescriptive actions to Take - which is vital when you are attempting to ensure that the community would not secure "clogged up" and decelerate for conclusion-person valued clientele. With this perception and working alongside their client, Cisco built rules around what to finish with PNDA's reports to prevent network outages and preserve issues working smoothly, before complications Take place. The approach helped Cisco find a market want while concurrently validating the expense of extra investments into its PNDA "implementation" and "building" services systems.

combine platforms to Innovate

individual know-how platforms are the springboard for innovating current products and services. it really is how 3M used adhesives to achieve Command strips.

New market alternatives frequently near from combining systems. 3M's periodical table of know-how systems allows for its engineers to blend and match applied sciences to with ease explore current probabilities and quickly create current products. 3M's tall efficiency Window films, as an example, are a composite of 4 systems: Adhesives, films, Nano-expertise, and light administration. with the aid of combining these applied sciences, 3M has tapped into a lot of current markets relish window tinting for vehicles, power management for business constructions through tinted glass, and security glass for home windows to avoid shattering from spoil-ins and earthquakes.

Cisco carried out an identical synergies when it utilized its "building" and "implementation" structures in its travail on PNDA. via combining these two systems right into a separate tall cost retort for telecommunication service providers, Cisco now has an providing for other purchasers that will besides live scaled across the market. 

retain It simple

while the word "platform" is as buzzwordy as "disruption" these days, any business can faucet into the vitality of technology platform innovation via retaining issues essential. define what makes your offerings in fact wonderful, classify these capabilities in anything route makes probably the most experience, after which flip people lax to explore, combine, and create solutions with purchasers that resolve actual complications.

that's how to create a route of life of innovation. and that's the route to develop into a protracted-time period innovator.

published on: Jun 19, 2018


Cisco releases current developer functionalities throughout intent-primarily based networking platform | killexams.com real Questions and Pass4sure dumps

Cisco is releasing current developer gear across its intent-based mostly networking platform and open APIs into Cisco DNA core, the command and control centre for campus, arm and belt intent-primarily based networks. DNA middle turns the community from a composite of hardware contraptions right into a separate gadget. With the supply of network-broad APIs, Cisco said it now enables builders to without problems programme this gadget, tapping into total the analytics and perception the community can give. Cisco is besides asserting that its developer neighborhood, DevNet, surpassed 500,000 individuals. Cisco is besides asserting three current developer initiatives to gas its innovation ecosystem, DevNet Ecosystem change, DevNet DNA Developer middle and DevNet Code trade. 

Already, 15 Cisco companions stand constructed resourceful items on the DNA core platform and are demonstrating them at Cisco are living.

In pile its giant and energetic DevNet community, Cisco mentioned it launched a brand current source of innovation as the network turns into increasingly programmable.

The DevNet Ecosystem change developer initiative makes it handy to ascertain and participate an software or platform developed for Cisco systems. DevNet Code alternate offers builders a station to entry and participate utility to rapidly build next-technology purposes and workflow integrations. DevNet DNA Developer middle is a one-stop-store for developers to build functions and integrations on the DNA core platform. It provides finished substances, capabilities, exhaust situations and gaining knowledge of materials for developers.

the current DNA core capabilities are scheduled to live purchasable during the summer. purchasers should buy these current functionalities from Cisco and its companions by route of existing subscription presents. DevNet's Ecosystem exchange, Code alternate, and DNA Developer middle are available now. Cisco and its companions tender a complete lifecycle of features to aid customers streamline the journey to definitely intent-primarily based networks.


LaSalle solutions ‘riding Evolution’ at Cisco live 2018 | killexams.com real Questions and Pass4sure dumps

news and research before you hear about it on CNBC and others. pretense your 2-week free ordeal to StreetInsider premium here.

ROSEMONT, sick., June eleven, 2018 (GLOBE NEWSWIRE) -- LaSalle solutions, a leading provider of technology lifecycle management features, is exhibiting today in sales space 1851 at Cisco are living, Cisco’s annual IT and communications convention, taking location June 10–14 on the Orange County convention core in Orlando. LaSalle will live in the world of solutions total the route through the week to divulge the superior facets of LAMPSM, the company’s industry-leading cloud-based asset and preservation shrink administration platform.

Cisco live offers a divide combination of in-depth technical education, working towards and chopping-aspect perception from the experts and businesses which are surroundings the agenda for the future of know-how and company.

“Cisco reside is a very excellent possibility for us to join with the partners and shoppers they travail with each day, in addition to to create current relationships,” referred to Steven Robb, president of the solutions neighborhood at LaSalle solutions. “we are fervent for showing company to sales space 1851 how their group of consultants and business-leading LAMP platform are changing the style their clients control the lifecycle of their Cisco hardware and application.”

As a leading provider of expertise lifecycle solutions and considered one of an elite neighborhood of Cisco partners with both Gold and Lifecycle lead fame, LaSalle solutions gives you finished options that complement Cisco capabilities via asset discovery, administration and upkeep shrink accuracy and optimization using LAMP.

LAMP demos can live given during the week within the LaSalle sales space, where guests will besides stand an occasion to Take a photo with the LaSalle-sponsored NASCAR race car parked in the middle of the business’s exhibition area.

LaSalle’s group of Cisco licensed Internetwork experts (CCIEs) are additionally at Cisco reside this week to host informational sessions in the Cisco assignation center, room 21. periods Take belt these days, Monday, June 11, via Thursday, June 14, from 12:30 to 1:30 p.m. Session topics encompass the information superhighway of things (IoT), utility-described vast belt community (SD-WAN), digital network architecture (DNA), gadget automation, and more.

“The technology business is consistently altering, and we're working challenging to no longer simplest adapt to these adjustments, but besides live sure that their customers are doing the identical,” referred to Robb. “The inheritance of LaSalle options is one of nonstop evolution. They hearken to their purchasers and travail closely with their partners to develop with them as wants and know-how alternate. collectively, we're using evolution to reside miles forward of the curve.”

About LaSalle solutions

centered in 1980, LaSalle solutions is a number one provider of expertise lifecycle asset management capabilities. LaSalle permits its shoppers to enrich their expertise operations through more suitable processes, management and reporting for greater planning and recur on funding. LaSalle solutions’ strategies, extraordinary customer service and strong, market-leading cloud-primarily based toolset, LAMP, permit purchasers to acquire improved enterprise results via transparency and professional results at their fingertips.

LaSalle options is a division of MB gear Finance LLC, a subsidiary of MB pecuniary financial institution, N.A., a business bank headquartered in Chicago. MB monetary Inc. is the publicly traded protecting business for MB fiscal pecuniary institution, N.A. and is traded on the NASDAQ as “MBFI.”

For more guidance on LaSalle options, tickle visit www.lasallesolutions.com and www.YouTube.com/LaSalleSolutions.

LaSalle options and LAMP are registered trademarks of LaSalle options within the u.s..

a photo accompanying this announcement is obtainable at http://www.globenewswire.com/NewsRoom/AttachmentNg/1d9682bc-1fc6-4c29-bb4d-a28b826faed3

Press Contact Beth Kirshenberg LaSalle answers847.823.9600 advertising@elasalle.com

Primary Logo

supply: LaSalle solutions

650-575 LCSAS Cisco Lifecycle Services Advanced Security

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Killexams.com 650-575 Dumps and real Questions

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FDA recollects Axcil and Desirin | killexams.com real questions and Pass4sure dumps

The U.S. meals and Drug Administration announced the deem of two sexual enhancement items -- Axcil and Desirin -- because of undeclared, ingredients.

Axcil -- described as a "male enhancement" product -- and Desirin -- talked about to "promote effeminate sexual characteristic" -- are over-the-counter medication allotted nationwide by using TWC world LLC of Mountain View Calif. The company initiated the willful Take into account after FDA assessments create the products embrace sildenafil, the lively ingredient of a FDA-authorised drug to deal with erectile dysfunction, in addition to two analogs -- sulfosildenafil and sulfohomosildenafil.

The FDA mentioned the undeclared chemical compounds pose a threat to consumers as a result of they could stand interaction with nitrates present in some prescription medication.

each Axcil and Desirin are sold via the cyber web in a 15-pill blister pack packaged in a box.

patrons with questions can contact the business at 650-575-0828.

Copyright 2007 by route of United Press foreign


OncoMed presents information on dissimilar Anti-cancer stem cellphone programs at American affiliation for melanoma research Annual assembly | killexams.com real questions and Pass4sure dumps

OncoMed prescription drugs, Inc. (Nasdaq: OMED), a scientific-stage company developing novel therapeutics that target melanoma stem cells (CSCs), or tumor-initiating cells, these days introduced data from an oral presentation and eight poster shows at the American affiliation of cancer analysis (AACR) Annual meeting in San Diego, CA April 5-9, 2014. The analysis presented at AACR spotlight OncoMed's drug discovery platforms along with preclinical and biomarker discoveries on its scientific-stage product candidates and a number of rising product candidates. a brief abstract of each and every presentation is provided beneath.

"The 9 shows at this yr's AACR Annual meeting divulge the breadth and depth of OncoMed's preclinical research and discovery work. Encompassing a lot of their clinical- and preclinical- stage candidates, facts being presented this week highlight the mighty anti-cancer stem cell undertaking considered throughout their portfolio, the alternatives to blend their compounds with commonplace-of-care, and their ongoing biomarker identification efforts being applied to programs in clinical development," observed John Lewicki, PhD, executive vp, Chief Scientific Officer.

Oral Presentation

Timothy Hoey, PhD, OncoMed's Senior vp of cancer Biology, gave an oral presentation entitled "using PDX models for anticancer drug screening" as a section of a methods Workshop on functions of affected person Derived Xenograft fashions to Translational cancer analysis. Dr. Hoey discussed the principal function of OncoMed's affected person-derived tumor pecuniary institution to deem anti-tumor and anti-cancer stem cellphone endeavor of its novel drug candidates; supply insights into skills scientific indications and dosing regimens; and generate and deem predictive biomarker hypotheses for software in medical trials. OncoMed has developed a substantial pecuniary institution of affected person-derived tumors, comprising greater than 200 tumors from a variety of tumor types, including the targeted phenotypic, useful and genomic characterization of each and every tumor.

Poster shows

medical-stage classes

Belinda Cancilla, PhD, Director, introduced abstract #910, "NOTCH3 expression is predictive of efficacy in pancreas tumor models handled with OMP-59R5, a monoclonal antibody focused on the NOTCH2 and NOTCH3 receptors," within the Predictive Biomarker 1 Poster Session. Expression of NOTCH3 mRNA by using subsequent-era sequencing in pancreatic tumor fashions correlated with response to OncoMed's anti-Notch2/three antibody, OMP-59R5, the station tumor efficacy correlated with NOTCH3 biomarker levels. A analysis exhaust simplest (RUO) qPCR assay for quantifying NOTCH3 mRNA expression the usage of Formalin-fixed, Paraffin-Embedded (FFPE) samples and an immunohistochemistry (IHC) assay for measuring tiers of NOTCH3 protein in tumor samples stand been developed. These assays could live used to correlate NOTCH3 ranges with patient response in ALPINE, a aspect 1b/2 clinical ordeal of OMP-59R5 in first-line superior pancreatic cancer sufferers. OMP-59R5 is section of OncoMed's collaboration with GlaxoSmithKline (GSK).

Marcus Fischer, associate Scientist, offered summary #3048, "OMP-59R5 (Anti-Notch2/three) inhibits tumor boom and reduces cancer stem phone frequency in patient derived SCLC xenografts," within the cancer stem cell Phenotype and performance 2 Poster Session. OMP-59R5 became enormously constructive in decreasing tumor boom and melanoma stem phone populations in fashions of diminutive cellphone lung cancer (SCLC). treatment with OMP-59R5 elevated the expression of differentiation markers and decreased CSC and Notch pathway genes. OncoMed is at present evaluating OMP-59R5 within the aspect 1b/2 PINNACLE ordeal in patients with SCLC.

Dr. Hoey besides offered summary #1898, "The composite of gemcitabine/nab-paclitaxel and anti-DLL4 (demcizumab) produces synergistic boom inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic melanoma," as section of the current Diagnostics, Therapeutic concentrated on, and Response Assessments Poster Session. Demcizumab, in composite with nab-paclitaxel (Abraxane®) and gemcitabine produced profound anti-tumor pastime and anti-CSC activity in a collection of pancreatic tumor xenografts. The triple composite of demcizumab, Abraxane and gemcitabine turned into greater efficacious compared with the combination of demcizumab plus gemcitabine alone and in several instances ended in shrinkage of tumors to undetectable stages. OncoMed is at present trying out the aggregate of demcizumab with Abraxane/gemcitabine in a section 1b peek at of superior pancreatic cancer sufferers and plans to initiate a section 2 study during this patient inhabitants later this yr. The demcizumab program is a section of OncoMed's collaboration with Celgene.

Story Continues

Chun Zhang, Senior Scientist II, offered summary #2830, "Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) with the aid of mining gene expression information of human breast melanoma xenografts," within the Predictive Biomarkers 2 Poster Session. A novel six-gene signature changed into derived based on the responsiveness of breast cancer xenografts to vantictumab and has been used successfully to precisely call the responsiveness of six extra xenograft models to this antibody. A scientific exhaust peek at various for this six-gene signature is under pile and should live used in the analysis of sufferers from OncoMed's ongoing aspect 1b study of vantictumab in breast melanoma. Vantictumab is a component of OncoMed's Wnt pathway collaboration with Bayer Pharma AG (Bayer).

Pete Yeung, associate Scientist, introduced summary #1907, "Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor extend and reduces tumor-initiating mobilephone frequency in patient-derived hepatocellular carcinoma and ovarian melanoma xenograft models," in the melanoma stem cell Phenotype and function 1 poster session. Researchers at OncoMed evaluated OMP-54F28 in models of hepatocellular cancer (HCC) and ovarian melanoma, two of the three signs that are at the flash being pursued in section 1b studies of this therapeutic candidate. OMP-54F28 proven undertaking as a single-agent and in combination with sorafenib in 4 HCC fashions and exhibited separate agent and composite pastime with paclitaxel in two ovarian cancer xenografts. A marked reduction in CSC frequency became accompanied following remedy with OMP-54F28 by myself and in composite with chemotherapy in both tumor varieties. OMP-54F28 additionally caused the differentiation of those tumors and blocked Wnt pathway genes. OMP-54F28 is a component of OncoMed's collaboration with Bayer.

Wan-Ching Yen, PhD, Senior Scientist II introduced summary #4547, "enhanced anti-tumor result of WNT pathway antagonists in composite with taxanes," within the mobile Cycle Mechanisms of Anticancer Drug motion Poster Session. The aggregate of Wnt pathway antagonists with taxanes in affected person-derived pancreatic or ovarian xenografts confirmed additivity and/or synergy that exceeded that observed when Wnt blockade is combined with DNA synthesis inhibitors gemcitabine and carboplatin. both Wnt pathway antagonists and taxanes are lively on the G2/M aspect of the telephone cycle, which is notion to interpret accompanied synergies. Taxanes are presently being mixed with either vantictumab or OMP-54F28 in divide ongoing aspect 1b stories.

"The presentations at AACR via OncoMed's scientists fortify the clinical data being generated across their development classes," pointed out Jakob Dupont, OncoMed's Chief scientific Officer. "These analysis outcomes give efficacious insights on capabilities combination regimens, where the addition of ordinary-of-care treatment plans may finest enhance the exercise of their anti-melanoma stem cell candidates and ebook their predictive biomarker programs."

rising Preclinical programs

Dr. Yen additionally introduced abstract #207, "twin focused on of DLL4 and VEGF signaling by using a novel bispecific antibody inhibits tumor growth and reduces cancer stem cellphone frequency," in the stem cell enlargement and melanoma stem mobilephone concentrated on Poster Session. OMP-305B83, OncoMed's novel tall affinity bispecific antibody focused on DLL4 and VEGF established big in vivo anti-tumor efficacy in a number stout tumor xenografts, delayed tumor recurrence following termination of chemotherapy, and decreased the frequency of cancer stem cells. twin inhibition of these two targets seems to demonstrate additive anti-tumor undertaking at doses the station blockade of both goal on my own elicited sub-most desirable endeavor. OncoMed expects to file an Investigational current Drug (IND) utility with the us meals and Drug Administration for OMP-305B83 within the second half of 2014.

Austin Gurney, PhD, Senior vice chairman of Molecular and cellular Biology at OncoMed, presented summary #1764, "Inhibition of R-spondin (RSPO) signaling reduces the growth of distinctive human tumors," within the current goals and agents 1 Poster Session. Inhibition of RSPO-LGR signaling with novel anti-RSPO antibodies inhibited tumor extend in numerous affected person derived xenograft models, including ovarian, colon, non-small mobile lung and pancreatic cancers. The RSPO blockade turned into constructive in decreasing tumor growth in tumors overexpressing RSPO, including tumors with genetic translocations, suggesting that levels of RSPO expression can besides function biomarkers in settling on patients surely to reply to RSPO blockade. OncoMed expects to file an IND for its lead anti-RSPO3 antibody in late 2014 or early 2015.

each the anti-DLL4/anti-VEGF antibodies and anti-RSPO programs are encompassed inside OncoMed's collaboration with Celgene.

"Our robust presence at this 12 months's AACR Annual assembly reflects the productivity of OncoMed's platform applied sciences and their commitment to continued discovery analysis, proprietary human tumor xenograft models, and predictive biomarkers," eminent Paul J. Hastings, Chairman and Chief government Officer. "OncoMed's preclinical and translational drugs travail informs and supports the efforts of their pile company, which is presently conducting 15 medical trials for 5 anti cancer stem cellphone brokers, and fuels the boom of their pipeline of anti-cancer stem cell therapeutics, as exemplified via the presentations of in vivo tumor efficacy facts for their pre-IND candidates, OMP-305B83 and Anti-RSPO3."

About melanoma stem Cells

cancer stem cells, or CSCs, are the subpopulation of cells in a tumor answerable for driving growth and metastasis of the tumor. CSCs, besides known as tumor-initiating cells, display inescapable properties which encompass the talent to divide and give tower to current CSCs by the exhaust of a process known as self-renewal and the talent to differentiate or change into the other cells that shape the bulk of the tumor. general cancer medication target bulk tumor cells however stand confined stand an repercussion on on CSCs, thereby offering a path for recurrence of the tumor. OncoMed's product candidates target CSCs by using blocking off self-renewal and riding differentiation of CSCs towards a non-tumorigenic state, and additionally stand an result on bulk tumor cells. OncoMed believes its product candidates are distinctive from the existing generations of chemotherapies and focused treatment plans, and stand the competencies to greatly influence melanoma medicine and the clinical outcomes of sufferers with cancer.

About OncoMed pharmaceuticals

OncoMed prescribed drugs is a clinical-stage company concentrated on discovering and establishing novel therapeutics targeting cancer stem cells. OncoMed has 5 anti-cancer product candidates in clinical development, including demcizumab (Anti-DLL4, OMP-21M18), OMP-59R5 (Anti-Notch2/3), OMP-52M51 (Anti-Notch1), vantictumab (Anti-Fzd7, OMP-18R5), and OMP-54F28 (Fzd8-Fc), which target key cancer stem phone signaling pathways including Notch and Wnt. OncoMed has two different antibodies in preclinical building, OMP-305B83 (Anti-DLL4/Anti-VEGF bispecific) and Anti-RSPO3, with Investigational current Drug filings deliberate for late 2014 or early 2015. OncoMed is additionally pursuing discovery of additional novel anti-CSC product candidates. OncoMed has fashioned strategic alliances with Celgene company, Bayer Pharma AG and GlaxoSmithKline (GSK). additional information will besides live discovered on the company's site: www.oncomed.com.

ahead-looking Statements

To the extent that statements contained in this press release are not descriptions of historical information involving OncoMed prescribed drugs, they're forward-looking statements reflecting the existing beliefs and expectations of management made pursuant to the secure harbor provisions of the deepest Securities Litigation Reform Act of 1995, including OncoMed's expectations concerning the capacity of OncoMed to strengthen its research and pile pipeline, including its discovery and preclinical pipeline and its anti-CSC therapeutics in clinical trials; OncoMed's potential to find and extend novel anti-CSC therapeutics; the tolerability of OncoMed's product candidates at efficacious doses; the skills of OncoMed's product candidates to greatly handle cancer medication and the medical result of sufferers with melanoma; the capabilities for a hit construction of predictive biomarkers for OncoMed's product candidates; the timing of scientific trials for OncoMed's product candidates; and the timing of Investigational current Drug filings for OncoMed's product candidates, together with OMP-305B83 and Anti-RSPO3. Such ahead-looking statements accommodate vast hazards and uncertainties that may trigger OncoMed's medical pile courses, future consequences, performance or achievements to vary significantly from those expressed or implied by using the forward-looking statements. Such risks and uncertainties encompass, amongst others, the uncertainties inherent within the preclinical and scientific development process; the hazards and uncertainties of the regulatory approval method; OncoMed's dependence on its collaboration companions, including Celgene, GSK and Bayer, for the funding of its partnered classes; OncoMed's talent to lift additional capital to assist the development of its unpartnered programs; OncoMed's dependence on the pile and advertising efforts of its partners for the business success of its partnered product candidates; OncoMed's reliance on third events to habits inescapable preclinical reviews and total of its scientific trials; OncoMed's reliance on separate supply third-celebration shrink manufacturing organizations to manufacture and provide its product candidates; OncoMed's capability to validate, develop and procure regulatory popularity of accomplice diagnostics; OncoMed's capacity to obtain market acceptance and business success of its product candidates as soon as regulatory approval is done; OncoMed's talent to find, ameliorate and commercialize extra product candidates; the capability of rivals to find, advance or commercialize competing products greater promptly or extra effectively; OncoMed's dependence on its Chairman and Chief government Officer, its Chief Scientific Officer, its Chief clinical Officer and different key executives; casual of third birthday party claims alleging infringement of patents and proprietary rights or in search of to invalidate OncoMed's patents or proprietary rights; and the skill of OncoMed's proprietary rights to tender protection to its applied sciences and product candidates. OncoMed undertakes no responsibility to update or revise any forward-looking statements. For a further description of the hazards and uncertainties that could cause specific results to differ from these expressed in these ahead-searching statements, in addition to risks concerning OncoMed's business in common, descry OncoMed's Annual file on kindhearted 10-okay for the fiscal yr ended December 31, 2013, filed with the Securities and change fee on March 18, 2014.

CONTACT: Investor Contact: OncoMed prescribed drugs Shari Annes Investor family members (650) 888-0902 shari.annes@oncomed.com

Media Inquiries: BCC partners Karen L. Bergman or Michelle Corral (650) 575-1509 or (415) 794-8662 kbergman@bccpartners.com or mcorral@bccpartners.com OncoMed pharmaceuticals, Inc. brand

supply: OncoMed pharmaceuticals, Inc.

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© 2014 Benzinga.com. Benzinga doesn't supply funding counsel. total rights reserved.


Farmers halt auction at Satana APMC | killexams.com real questions and Pass4sure dumps

NASHIK: Farmers on Tuesday halted public sale at the Satana Agriculture bear Market Committee (APMC) wholesale onion market for an hour and staged a street blockade in protest in opposition t low fees to the commodity in the morning session.The auction resumed an hour after the APMC officials satisfied the agitating farmers. At different APMCs within the district, the public sale of onion persisted as tolerable with benchmark wholesale expenditures being recorded in the latitude of Rs seven-hundred to Rs 1,a hundred a quintal.

Satana APMC secretary A k Bhamare mentioned, "The farmers halted onion auction for an hour from 10.30 in the morning to protest the low prices. They additionally staged a 'rasta roko' backyard the main gate of the APMC. The public sale, despite the fact, resumed at 11.30 am after they satisfied them to participate in the process. The habitual wholesale onion expense turned into Rs 850 a quintal, whereas the minimal and highest expenses were recorded at Rs one hundred and Rs 1,300 a quintal, respectively. respectable nice onions obtained costs in the scope of Rs seven hundred to 1,300 a quintal, whereas the terrible first-class ones bought fees as much as Rs 600 a quintal."

He spoke of, "The hailstorms and unseasonal rains in February and March had hit Satana tehsil, affecting the high-quality of onions. most of the crops achieving the market are of groundwork exceptional. due to this fact, there's massive a contrast in the wholesale onion expenses. The excellent fine onions are getting respectable prices, while the destitute first-class plants stand become reduce costs."

Shetkari Sanghatana (Nashik district) president Govind Pagar spoke of, "How will the farmers live on in the event that they cannot even secure well their production prices? they are able to stage demonstrations across talukas within the district if there isn't any improvement in onion costs inside a week."

An legitimate at Lasalgaon APMC observed, "the advent of onions within the scope 15,000 to 18,000 quintals a day, but the excellent of onions is not so decent as most of the crop has been broken within the synchronous hailstorms and unseasonal rains. best 40 per cent of the entire arrival is of decent great."

The common wholesale onion expense at Lasalgaon changed into recorded at Rs 950 a quintal on Tuesday. The minimum and highest fees had been recorded at Rs 300 and Rs 1,478 a quintal, respectively. around 18,000 quintals of onions stand been auctioned at Lasalgaon throughout the day.

At Pimpalgaon APMC, the commonplace wholesale onion expense changed into recorded at Rs 1,100 a quintal. The minimal and optimum expenditures stand been recorded at Rs 351 and Rs 1,770 a quintal, respectively. round 14,000 quintals of onions were auctioned at Pimpalgaon.

The general wholesale onion fee at the Yeola APMC become recorded at Rs 700 a quintal. The minimal and optimum fees had been recorded at Rs 200 and Rs 1,000 a quintal, respectively. around 1,500 quintals of onions stand been auctioned at Yela.

At Satana APMC, the habitual wholesale onion expense became recorded at Rs 850 a quintal. The minimal and highest prices stand been recorded at Rs a hundred and Rs 1,000 a quintal, respectively. around four,500 quintals of onions stand been auctioned at Satana.

normal wholesale onion fees in Nashik APMCs

APMCs Nov 29 Dec 6 Jan 13 Feb 5 April 10 April 17 April 25 can besides 6

Lasalgaon 1,700 1,750 925 740 725 1,011 975 950 Pimpalgaon 1,651 1,seven-hundred 950 675 801 921 800 1,a hundred Yeola 1,300 1,600 850 650 575 750 740 700 *observe: total figures are in rupee per quintal


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