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644-344 exam Dumps Source : SP Video aspect III Wireline

Test Code : 644-344
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Cisco SP Video aspect III

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Cisco’s lengthy-standing perception has whole the time been that groups should evolve to pressure forward and lead through market transitions.  The equal is remedy for their government skill.  Evolving their talent requires putting them in unique roles, increasing their perspective and ability sets and bringing fresh ideas and energy to the company. here's what we’ve these days performed with Edzard Overbeek’s unique flow from SVP of their Asia-Pacific-Japan region to lag of their international capabilities company and Bruce Klein’s circulate from SVP of Public Sector sales to the pinnacle of their international associate organization.

during the eventual yr, they occupy refocused their engineering organization for agility, more advantageous determination making, and a renewed focal point on innovation.  The market partake numbers discourse for themselves and their consumer self credit has by no means been enhanced.  we've a powerful leadership group and the enterprise community leaders occupy tested powerful execution.  Now the time is remedy for us to drive the next section of their organizational evolution.

With that, we're blissful to promulgate Padmasree Warrior will extend her role to develop into Cisco’s Chief technology and approach Officer where she should exist chargeable for settling on consumer and commerce transitions and selecting Cisco’s approach to address them.  Padma will travail intently with Cisco’s engineering, container, operations and services management, and may outline strategy, investments, acquisitions and the evolution of Cisco’s know-how companion ecosystem.   additionally, Padma may exist liable for conception leadership around Cisco’s products and architectures, technical ability building and recruiting, and she or he will raise her time with external stakeholders.  The commerce group CTO’s will document dotted line to Padma to allow powerful alignment between technology approach, enterprise mode and M&A pastime.  during the eventual 4 years, Padma has based a major tune record of results, corresponding to constructing Cisco’s mode and execution round architectures, cloud, bona fide expertise approach framework, and attracting and developing commerce main technical talent.  They explore forward to accelerating their market position beneath Padma’s strategic course.

After 13 years of outstanding provider to Cisco, Ned Hooper should exist leaving the instant Cisco family to shape an impartial funding partnership commerce and to pursue his intent to exist a primary investor.  Ned has been engaged on his intent with us over a few months, and they seem forward to partnering with him in his unique activity.  Ned has a distinct zeal and ability for funding and approach, and may focus of attention on this in the subsequent piece of his profession.   Ned pioneered the mannequin for gigantic-scale M&A at Cisco and drove giant transactions for the enterprise corresponding to Tandberg, WebEx, Airespace, Starent and NDS.  additionally, he has managed their $2B funding portfolio with each strategic and economic returns to the business. Ned’s strategy and company building group will now document to Padma.  they would want to thank Ned for his contributions, leadership, friendship and his persistent oblige to at whole times carry out the privilege issue for Cisco.

ultimately, Pankaj Patel will assume the management of Cisco’s engineering organization.  Pankaj will oblige innovation, operational excellence and agile construction throughout their products, options and architectures, and continue to enhance their relevance with their expanding customer base.  Pankaj’s profound client relationships and extensive engineering capabilities, combined together with his ability to mentor and grow properly engineering ability will serve Cisco well as they oblige the subsequent section of engineering management for the business.  when you could exist accepted with Pankaj’s carrier company adventure, he previously spent sixteen years in the commercial enterprise area.  over the eventual 13 years, Pankaj developed and grew Cisco’s carrier company commerce which today money owed for about 35% of Cisco’s direct product earnings. Pankaj’s leadership in key service issuer areas corresponding to core routing, piece routing, SP mobility and SP video has positioned Cisco extremely smartly for the long run. whole the artery through his tenure Pankaj has delivered a significant number of products to the Cisco portfolio, addressing a wide array of customer needs.  over the eventual 12 months because the co-leader of engineering, Pankaj has accelerated his involvement in Cisco’s commercial enterprise company, as the intersection points between service provider and commercial enterprise approach closer together.

As they dwell focused on being the most fulfilling Cisco for their valued clientele, companions, buyers and personnel nowadays, they in no artery lose song of the station they wish to proceed sooner or later.  we're excited about this evolution in their corporation. delight exist a piece of us in congratulating Padma, Pankaj and Ned on the next aspect of their respective journeys.

John Chambers and Gary Moore


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CNN LOU DOBBS MONEYLINE | existent Questions and Pass4sure dumps

here's A RUSH TRANSCRIPT. THIS copy may additionally now not exist IN ITS remaining shape and can exist updated.

this is A RUSH TRANSCRIPT. THIS replica might moreover now not exist IN ITS final shape and can exist up-to-date.LOU DOBBS, HOST: Tonight, President Bush puts corporate the usa on note: shape up or puss the Justice department.

Democrats accuse the president and Republican lawmakers of being too soft on corporate abuse.

we'll occupy are animated reviews for you from the White condo and Capitol Hill.

WorldCom's CEO sends a note to the president promising cooperation and reform.

Xerox admits it made a $4-billion mistake however says, nonetheless, it isn't any WorldCom.

we'll occupy a distinct report there as neatly.

The Arizona wildfire is even better tonight. or not it's damaged through fireplace containment strains. Two further towns tonight are in jeopardy.

And former Enron personnel at the second are the women of "Playboy" journal.

ANNOUNCER: here's LOU DOBBS MONEYLINE for Friday, June twenty eighth. privilege here now Lou Dobbs.

DOBBS: respectable night.

President Bush nowadays lashed out against company misbehavior. Mr. Bush referred to groups necessity to boost the bar and never fudge their numbers. day after today, the president will exercise his radio address to induce company leaders to pellucid up their acts.

we now occupy two studies tonight. They start with Kate Snow on Capitol Hill and Senior White house Correspondent John King.


JOHN KING, CNN SENIOR WHITE residence CORRESPONDENT: neatly, Lou, the president may exist speakme about this theme more and more in the days ahead. You mentioned the radio ply the following day. The president will once again urge corporate leaders to expose accountability, double-determine their accounting practices.

Mr. Bush moreover will proceed back and forth to unique york metropolis on July 9th, CNN is advised, and convey a speech dedicated entirely to the theme of company responsibility.

The White apartment seizing on this story, making an attempt to rep the initiative. Mr. Bush announcing the government is looking at what it might carry out administratively. he's urging the Congress to ensnare a glance at disclosure rules as well.

Mr. Bush asserting he's concerned about this theme not only as a result of the circumstances of WorldCom and Enron, but he believes it's inflicting a slowdown in client -- a scarcity of purchaser self credit in the stock market and having an palpate on the universal U.S. economy.

(begin VIDEO CLIP)

GEORGE W. BUSH, PRESIDENT OF the U.S.: corporate the united states has bought to endure in judgement there's a much better calling than making an attempt to fudge the numbers, trying to coast a thousand million here or one billion there and hope nobody notices.,

but you've got a accountability in this country to whole the time exist above board. They anticipate unreasonable requirements in their faculties, they are expecting unreasonable standards in company the usa as smartly, and i intend to implement the legislations to exist confident that there are elevated specifications.


KING: The White apartment realizing this is not just a coverage debate but additionally a political debate. Democrats making the case in this midterm election 12 months that the president and his Republican birthday party are guilty for lax law, are too comfortable with huge enterprise. The White apartment says Mr. Bush is determined to rep out forward on this one and never let Democrats create that case.


DOBBS: John, the president calling upon Congress to behave privilege here. The White condo has been helping Senator Phil Gramm's efforts to cease reform of accounting and company reform on Capitol Hill. How does this whole rectangular off?

KING: smartly, definitely, when you consider that the Enron disclosures and now the WorldCom disclosures, the White condo is asserting that it's asking the SEC Chairman Harvey Pitt to carry out greater administratively and says it's going to shove in the Congress.

however you might exist precisely commandeer in that some Democrats on Capitol Hill order there are as a minimum inconsistencies, some order hypocrisies, within the administration's approach. whole this now a piece of a political debate in this midterm election year as well as a extremely reputable policy debate over simply precisely the station is the role of government in telling company the us the artery to govern itself.

And, John, the president is undergoing a colonoscopy this weekend. Any word as to why he is going to exist below sedation during that examination?

KING: His doctors suggested this, Lou. The mode may moreover exist extremely uncomfortable. Mr. Bush has had two during the past wherein benign polyps were eliminated. His docs order he was sedated at the remaining one.

they say, #1, sedation minimizes discomfort on the patient. And, quantity two, they are maxim it makes it workable for then the doctors to carry out a greater thorough job as a result of, if the affected person is uncomfortable, the medical doctors are likely to rush the technique.

all and sundry privilege here at the White residence maxim here is a really hobbies process for the president to try this. He has no signs in any respect. he's in wonderful health, his medical doctors say.

but he will temporarily switch power to the vp. Mr. Bush says it is a wartime precaution, anticipating Dick Cheney could exist appearing president of the united states someplace within the area of one to three hours day after today.


DOBBS: ok, John. thanks very a mighty deal.

Senior White condo Correspondent John King.

Democrats, as John reported, try to profit political abilities from these corporate scandals. nowadays, Senate Majority chief Tom Daschle referred to company corruption is threatening the pecuniary system, and Daschle accused Republicans of backing policies that led to company misbehavior.

For more on the story, i am joined by artery of Kate Snow on Capitol Hill.


KATE SNOW, CNN CONGRESSIONAL CORRESPONDENT: Lou, Tom Daschle additionally said that he's heard from a lot of CEOs over the closing brace of weeks, and he stated they partake his outrage over things fancy WorldCom. He says they respect as an abominable lot as they do, lawmakers do, that, in Daschle's words, there may exist bought to exist a change within the legal guidelines, the legal guidelines deserve to exist reinforced.

He changed into very pellucid that you simply can't retain the only blame on the Bush administration for WorldCom's failure, but he does order that he believes, quote, "a laissez-faire attitude during this administration has helped create the benevolent of ambiance that exists these days."

(begin VIDEO CLIP)

SEN. TOM DASCHLE (D-SD), SENATE MAJORITY leader: there may exist too a mighty deal executive rules. there is too a friendly deal govt involvement within the corporate sector. And what they want now's to eradicate government and whole of its presence from any oversight obligations.

And, piece by piece, they dismantled the regulatory ambiance that they had and, in tremendous measure, created this sense of laissez- faire, of just total unwillingness on the a piece of enforcement or regulatory corporations to play a job.


SNOW: Now, obviously, Democrats are seizing on this concern, hoping that it might profit them some votes this topple in the election.

whereas some Democratic strategists occupy observed they're now not going to exist gleeful about americans dropping jobs, not at all, an additional strategist did order to me this turned into a fortunate ruin, this WorldCom story.

condominium Democratic chief Dick Gephardt being even a minute more forceful, a bit more political than Tom Daschle became. He observed -- he cautioned that it was the past eight years of condo Republican ply -- Republican ply of the apartment of Representatives -- that has brought about one of the vital issues because they did nothing about corruption.

And, nowadays, a Republican shot back, invoking bill Clinton's legacy.

(begin VIDEO CLIP)

REP. WILLIAM THOMAS (R), CALIFORNIA: if you wish to determine a mannequin for individuals now not behaving morally -- or the style of maxim it is: carry out the remedy factor even when individuals don't seem to exist watching -- I suppose you will locate that the Oval workplace has a whole lot more similarity to the board play than the ground of the house of Representatives.

if you're hunting for someone who set the ethical tone for the decade of the '90s, I carry out not consider you necessity to seem any farther than the previous president's habits.


SNOW: And Republicans order they are equally upset about what's took station at WorldCom, they too want action, but they with ease don't descry it as a political issue, Lou.

they order that if Democrats are going to are attempting to play up the minute man versus the potent during this crusade season, this operative observed, well, perhaps it will travail simply as smartly as it did for Al Gore.


DOBBS: whole appropriate, Kate. One query on this. Tom Daschle, gleeful or now not, regarding the laissez-faire attitude in rolling lower back regulation. The Telecommunications Reform Act of 1996 become signed by bill Clinton. How does that...

SNOW: i am unavoidable Republicans will factor to that too, and they have. They've spoke of, "appear, you can not order that the previous eight years has been totally below Republican control. You had President Clinton within the White condo."

They've made that aspect time and again when this has approach up. and that they've additionally said, you know, for a short time -- smartly, the Senate's been in ply now for a short time of the Democrats. What about that?


DOBBS: adequate. thank you very a whole lot.

Kate Snow reporting from Capitol Hill.

The parole board in California that has been due to the fact whether to liberate an infamous Manson friend who's serving lifestyles in detention focus for her role in killing sprees in 1969 -- Leslie Van Houten become 19 on the time.

here is a reside photo of Leslie Van Houten. She become 19 at the time of those killings. She has faced a parole board 13 times. each and every time, she's been turned down. Her parole again has been turned down.

Let's hear in.

(begin VIDEO CLIP)

UNIDENTIFIED CALIFORNIA PAROLE BOARD MEMBER: She, although, had been arrested for auto theft. They had been no longer interestingly prosecuted. however she did occupy prior criminal activity in that she became a drug consumer, together with LSD, marijuana, methadrine, mescaline, and benzadrine, and this drug exercise had been happening for at least a brace of years.


DOBBS: This, the California Parole Board, denying Leslie Van Houten, a member of the notorious Manson family unit gang, once more for a 14th time being denied a request for parole, and her being sentence continues.

"surprise" and "outrage," the words used via WorldCom's chief executive officer, John Sidgmore, in a note to the president these days.

Sidgmore talked about he became bowled over by artery of the invention of a $4-billion fraud at his company. He additionally outlined changes he's making in WorldCom's enterprise practices, and, among those, 17,000 layoffs that begun today.

Sidgmore additionally pledged replete cooperation with the a number of investigations of WorldCom.

And, in the meantime, a Mississippi arbitrator has issued a restraining order that bars WorldCom, its auditors, and its personnel from destroying files. The choose moreover stated he would nominate a computer screen to oversee doc retention. An SEC order this week simplest advised that documents exist preserved.

yet another accounting scandal at Xerox. Xerox will ensnare out virtually $2 billion of profits that it already suggested. An audit confirmed that Xerox posted these revenues earlier than they were in fact made.

Bruce Francis has the file.


BRUCE FRANCIS, CNN CORRESPONDENT (voice-over): Xerox admits that again in the late '90s, it robbed the longer term to create the latest seem improved than it in fact become. The company is revising five years of outcomes.

Xerox needed to restate its financials after settling expenses with the Securities and change commission again in April and paying a $10- million satisfactory.

In a press release, CEO Anne Mulcahy said Xerox these days closes a tough chapter in the business's background. Mulcahy declined to exist interviewed for their story.

score the inventory a purchase for the judgement that November, Peter Ausnit thinks that Xerox can whirl round.

PETER AUSNIT, DEUTSCHE pecuniary institution SECURITIES: They descry Xerox as a corporation that can deserve a substantial amount of cash over the next brace of years, peculiarly when enterprise conditions normalize.

FRANCIS: but traders, certainly folks that purchased Xerox privilege through the late '90s, could no longer determine it so easy to overlook Xerox's inaccurate accounting.

As piece of its restatement, Xerox now admits it should occupy booked much less earnings in 1997, 'ninety eight, and '99, a time when the inventory was taking off. however the company insists that the sales -- in this case, gadget leases -- are actual and that the revenue from the late '90s really belongs in 2000, 2001, and past. for instance, 2001 finally ends up searching superior than earlier than by using half one billion dollars.

The foundation line $1.9 billion may exist taken out of revenues already mentioned.

but the writer of "How organizations Lie" says carry out not carve what Xerox did.

RICHARD SCHROTH, creator, "HOW groups LIE": I don't consider it's a small, minute accounting error in any respect. companies fancy Xerox and others who occupy been named to the Fortune 100 greatest businesses and other such -- occupy a accountability to exist brazenly mindful on these forms of things.

(conclusion VIDEOTAPE)

FRANCIS: neatly, former Xerox auditor KPMG maintains that they occupy been careful, inserting out a press release these days standing via its prior travail with Xerox and calling the copier business's restatement an unbelievable about-face.

Lou, they're on the fence. DOBBS: The auditor now not agreeing with the restatement.

FRANCIS: now not agreeing with the restatement, no longer agreeing with Xerox, no longer agreeing with the SEC, not agreeing with PricewaterhouseCoopers.

DOBBS: And they occupy now seen loads of play for disagreement, however it does create you marvel how anybody can order they were cautious when there may exist an argument of $2 billion.

FRANCIS: elevated priced selections that cost traders some huge cash, Lou.

DOBBS: And we're, unfortunately, getting used to lots of these choices that can suffuse traders some huge cash.

Bruce, thanks a whole lot.

stocks closed minute modified on the day despite the latest scandal. today marked the conclusion of the 2nd quarter. That quarter noticed main indexes register double-digit losses.

nowadays, the Dow Jones Industrial typical fell more than 26 aspect. The Nasdaq rose pretty much 6 features. The S&P 500 dropped virtually a degree.

Jan Hopkins could occupy finished market coverage for us in just moments.

Tonight's MONEYLINE quick vote query is concerning the markets. we'd fancy to exist watchful of: carry out you consider that this inventory market has at eventual hit backside? that you could cast your vote by means of going to -- -- and while you're there, which you can whole the time ship us an electronic mail as well. they are going to occupy the outcomes of tonight's vote later in the broadcast.

We additionally want to ensnare this probability to ensnare a explore at your recommendations on corporate scandals. Susan Christie writes in to assert, "With Enron, Arthur Andersen, and now WorldCom, the phrase 'Figures not ever lie, however liars at whole times figure,' became on no account extra actual."

John DePetris, "Why should al Qaeda intent greater assaults when we've Enron, WorldCom, Xerox CEOs, CFOs, et cetera, doing what the terrorists would dream of doing? it is destroying the American pecuniary market."

And Brian Scott of Canada says, "Is it any question yourself that current anti-globalization protesters don't occupy any faith in the present capital system. whole they descry are thieves, cheats, and liars whose best pastime is to complement themselves on the fee of traders and personnel."

we are going to occupy greater of your options later in the broadcast. And, as whole the time, which you could e-mail us at And they at whole times question that you simply comprise your identify and address.

Let's flip now to these wildfires raging within the western a piece of the nation. a brand unique hazard tonight in Arizona. That big hearth immediate the city of note Low, Arizona, has broken via a containment line, threatening a nearby subdivision.

Thelma Gutierrez has greater on the Story for us.


THELMA GUTIERREZ, CNN CORRESPONDENT: Lou, at this time, what's going on is that firefighters are working to establish a fireplace line to shove that fire again. The wind has kicked up a minute bit in exactly the past few minutes, which is not a superb factor obtainable.

additionally remaining nighttime, the fireplace had moved down the back aspect toward the city of Heber. Firefighters working day and night to try to dangle these hearth lines to redeem these communities. they occupy got felt and that they mentioned past nowadays that, if they're able to hold those strains through the day, they'll occupy an excellent probability of saving the communities.

Now, nowadays and the following day, the crimson lag and endemic officials occupy begun what they occupy got called van tours for residents who misplaced their buildings. The residents will most efficacious occupy a casual to view their properties. as a result of safety concerns, they will not exist allowed to in reality rep off and proceed into their property. And officers occupy mentioned that on account of the choice nature of these tours, cameras aren't allowed in.

Now, to date, 419 acres of Ponderosa pines occupy burned up here in the expose Low enviornment, and more than 50 p.c of the land that has burned is on the Apache reservation land that has had a devastating palpate on tribal individuals. up to now, they order that two sawmills occupy now closed down. three hundred jobs out here could exist lost. the whole estimated cost of the bushes they occupy got lost: $237-million.

(start VIDEO CLIP)

LUCI BENALLY, APACHE TRIBE MEMBER: i am hoping that whole and sundry is watchful of that now not best carry out americans within the demonstrate Low and Pinetop areas stand to lose their homes, however their tribe has lost so a whole lot and too much. We're speakme thousands and thousands and thousands and thousands and tens of millions of bucks in an pains to on no account exist replaced in their lifetime.


GUTIERREZ: A spokesperson for the Apache tribe advised me a short while ago that it'll a century earlier than they're in a position to rep better from this fireplace, Lou.

DOBBS: Thelma, thank you very much.

Thelma Gutierrez from demonstrate Low, Arizona.

well, officers in Colorado are hoping that calmer weather will encourage their combat in opposition t wildfires. Two fires immediate Durango, Colorado, occupy burned more than 70,000 acres and destroyed dozens of homes. these fires are best a 3rd contained.

in the meantime, an almost a hundred and fifty,000-acre hearth near Denver may still exist absolutely beneath manage via Sunday.

coming up tonight, the markets grappling with a surge in earnings restatements by artery of corporate the us. we'll investigate the competencies for extra surprises forward.

Wall highway, as soon as the envy of the area. Now lots of the world is questioning their mannequin of capitalism. they are going to occupy that record for you.

we will verify the problem that the united states faces in sustaining the battle towards terrorism and radical Islamists in their MONEYLINE "Economist" magazine train on American management, unique directions.

And Henry Kissinger will exist privilege here to examine the us's peace efforts in the core East.

All of that and more nevertheless forward. live with us.

(industrial damage)

DOBBS: Two foremost enterprises came forward to create mighty restatements of their prior outcomes this week. The query nobody can reply tonight is how many more restatements are there.

Peter Viles has the story.


PETER VILES, CNN CORRESPONDENT (voice-over): As one-two punches go, this turned into an enormously expensive mixture. WorldCom, then Xerox, $6 billion worth of crummy accounting. The number of company revenue and salary restatements had already been rising, spiking an abominable lot extra sharply in the simultaneous economic downturn than it did in the ultimate one.

So the query traders are asking: is this the top or just the beginning? naturally, the SEC isn't able to declare triumph on bogus bookkeeping.

HOWARD SCHILIT, focus FOR fiscal analysis & evaluation: The travail of the SEC is genesis to determine upon up pace. they occupy anything fancy 65 existing investigations. The SEC just bought a big raise in their funds. and that i suppose the power continues to exist on the SEC and different regulators to pellucid up the mess.

VILES: The SEC eventual nighttime took motion so one can oblige CEOs to swear, beneath oath, to the accuracy of profits stories, a troublesome step meant to flush out any accounting scandals that are hiding in corporate books.

LYNN TURNER, FORMER SEC CHAIRMAN: Harvey Pitt has to lag a step additional and say, "now not most efficacious carry out I covet you to signal on the final analysis privilege here in case you ship for your subsequent set of economic statements, but you necessity to recollect if those conclude up incorrect, we're going to note round and ship you to penitentiary." VILES: that is a superb point, however Harvey Pitt has been there and spoke of that. here's what he referred to this week when asked what happens if these sworn declarations become false?

HARVEY PITT, SEC CHAIRMAN: You proceed to prison since it's fraud if you certify it and it exist false.

(conclusion VIDEOTAPE)

VILES: In light of this hard talk from the SEC, there is a few hypothesis they may moreover in reality descry greater restatements within the coming weeks than they might occupy otherwise.

corporate the united states basically has six weeks to rep its books so as. Then genesis in mid-August CEOs will ought to swear below oath that these books are the fact.


DOBBS: it exist a shame that it exist approach to this, but Harvey Pitt's thought privilege here in terms of signing and swearing to those fiscal statements -- it may possibly become the solution here or a mighty piece of it.

VILES: it's a means to create everyone say, "Come ahead. whole those that haven't committed accounting fraud, step ahead." It turned into the president's conception initially.

DOBBS: adequate. Pete, I recognize it. thanks.

The scandals sweeping throughout corporate the usa are elevating massive questions in regards to the effectiveness of the mannequin of capitalism, its apply during this nation. international buyers, some of them, are reluctant to retain are retain their cash during this country, and American accounting practices are being challenged as on no account earlier than.

Kitty Pilgrim has the story.


KITTY PILGRIM, CNN CORRESPONDENT (voice-over): For years, the American company mannequin turned into touted because the most useful on earth, U.S. prevalent Accounting principles advanced, and corporate governance probably the most advanced. With debacles at Enron, ImClone, Tyco, and Adelphia dominating U.S. headlines, Europeans are starting to gloat.

"In the usa, whole that glitters isn't gold," Deutsche bank's former CEO Rolf Breuer mentioned in a speech this week. however the usa's gadget become golden for a long time and had the numbers to note it. Unemployment lessen than in Europe, capital markets within the U.S. outperforming Europe, bigger productivity numbers, and a tenacious greenback.

but now the dollar has fallen about 10 percent towards the euro up to now this yr. Markets are foundering, and the enormously touted accounting necessities being reexamined under a congressional microscope, satisfactory to create the White apartment retreat the American method.

ARI FLEISCHER, WHITE condo SPOKESMAN: The president believes that america's free commercial enterprise device is a system this is performed very well for the American people, or not it's resulted in lots comfort, or not it's resulted in a tenacious culture for the American americans.

PILGRIM: And a glance on the markets indicates, over the eventual two years, the Dow held up more suitable than stock indexes in Frankfurt, London, and Paris, down 28, 38, and forty two p.c respectively.

Some factor out the U.S. company mannequin is always evolving and improving from its missteps.

ROBERT SCHILLER, YALE college ECONOMIST: From decade to decade, they exist trained further and further about how to elope organisations, but a piece of the technique contains experimentation, and experimentation has unpredictable penalties, and some undesirable consequences, and so they are -- from one decade to the subsequent, they occupy to straighten out these blunders as neatly.


PILGRIM: So, during the past few months, there were changes in the artery removed places companies are operating, and Europeans are now pushing for more unbiased board contributors and superior transparency, and the CEO incentives are moreover being reexamined. briefly, the becoming pains are being felt whole around.


DOBBS: but nevertheless free markets and freedom. it's working.

PILGRIM: or not it's working, and...

DOBBS: a bit uneven every now and then.

Kitty, thanks plenty.

Kitty Pilgrim.

nevertheless forward here, the eventual piece of their collection with the "Economist" magazine. Tonight, they seem to exist at the challenges dealing with the united states in sustaining the battle towards radical Islamism and terror.

Blue chips fizzle on the ultimate day of the 2d quarter. The NASDAQ ends by far greater, however a tough quarter it become. we'll exist telling you about that.

And the women of Enron panoply their talents with the assist of "Playboy" journal.

All of that and greater nonetheless forward. dwell with us.

(industrial smash)

DOBBS: shares closed the 2nd quarter minute changed on the day despite this newest accounting information from Xerox.

Jan Hopkins has the marketplace for us now.


JAN HOPKINS, CNN CORRESPONDENT: Lou, given whole of that, it was no longer a defective displaying for shares.

The market in reality brought to yesterday's rally. but the Dow did slip into negative territory simply earlier than the closing bell when the president announced he would transfer power to the vice president privilege through his colonoscopy tomorrow at Camp David.

For the day, the Dow become down, and it became down for the sixth week in a row. Nasdaq ended the day and week better. The S&P slipped just a little.

Christine Romans is at the unique york stock exchange, and Greg Clarkin is on the Nasdaq.


CHRISTINE ROMANS, CNN CORRESPONDENT: well, Jan, another unstable day and two-billion shares traded today to immediate this quarter.

Xerox, as you'll predict, lost 13 p.c because of that restatement, however NIKE soared after mighty fourth-quarter earnings. Auto shares rallied today on hopes for a rebound in June motor vehicle earnings. And Philip Morris won after a horrific week. it exist nonetheless down sixteen % this quarter, though. Tyco additionally gaining these days on unreasonable hopes for its CIT IPO.

however it's been a abominable quarter for Tyco, down fifty four %. ensnare a glance at AOL, parent of this community, AT&T, IBM, and GE, whole generally held stocks, whole struggling keen percent losses over the past three months.

Now to the NASDAQ and Greg.

GREG CLARKIN, CNN CORRESPONDENT: And, Christine, relatively reticent day for intelligence in huge identify tech shares.

Take a explore returned on the quarter. descry how those massive cap know-how shares fared. ensnare a glance at sun Microsystems down virtually forty three % for the 2d quarter. Intel down pretty much forty percent. Oracle dropping virtually 26 %. You had Cisco with a 17-percent loss. Microsoft down 8.6 percent.

but you are looking to contend steadiness? How about Dell computing device? It whole started the quarter trading at $26.11. It ends the quarter trading at $26.14. That three-penny gain makes Dell desktop the most desirable- performing big cap technology stock for the 2nd quarter.

Jan, again to you.

Thanks, Greg. HOPKINS: The Nasdaq simply comprehensive its worst half-year on listing. it is down 25 p.c for the 12 months thus far, and that i suppose traders don't deserve to exist reminded that here's the third yr in a row that the Nasdaq is reduce.

For the S&P, this is the first half-yr in 30 years, a lack of 14 %.

however, Lou, a unique quarter begins on Monday.

DOBBS: some thing to explore ahead to, as i am confident basically every person is.

Jan, thanks.

smartly, accounting scandals, of path, are the focus of attention this week. company misbehavior at WorldCom, Xerox dealing yet another blow to investor self belief. buyers wondering just what on the planet is occurring and what's next.

With me now within the studio is Steve Forbes, the editor of "Forbes," designate Morrison, editor of "BusinessWeek," and joining us from la, invoice O'Neil. he's the leading man at "buyers enterprise every day."

And or not it's friendly to occupy you whole here.

Let me begin, if i may, bill, with you. This market behaving, on the very least, badly within the puss of perilous intelligence on profits and scandals. What's occurring, to your judgment?

invoice O'NEIL, "traders enterprise day by day": well, I feel that or not it's the aftermath of the massive tulip bulb craze that went on in '98 and '99. In Holland, everyone purchased tulip bulbs and they went loopy over them, and it whole blew up. and that's what took station in excessive-tech and biotech.

DOBBS: i used to exist considering extra, invoice, about this week. They discovered concerning the tulips a very long time in the past.

O'NEIL: sure. neatly, this week, the Nasdaq has been going down on account that January 1. it exist had three waves down and this closing one is a minute steeper, and it undercut a low. however I believe you picked up some brief selling and there's been a whole lot of news. so you're doubtless in along the lows.

The market has in fact shifted to customer shares. So i am no longer so pellucid that these fallen leaders in the high-tech sector are absolutely elementary for a market it is slowing to regularly rep well over time.

DOBBS: Mark, your recommendations?

MARK MORRISON, MANAGING EDITOR, "BUSINESSWEEK": neatly, I suppose the market reacted pretty neatly on the grounds that the extent of the defective information this week. The WorldCom and Xerox announcements had been rather stunning. Yet the market, after that news, acted relatively well, turned into relatively reliable.

and that i believe that in a selective means, the market did might exist correct some of the businesses that -- the station accounting questions are nevertheless lingering, those that use...

DOBBS: Amongst people that are...

MORRISON: EBITDA, the ones which occupy pro forma accounting and occupy pushed that idea. these -- the market reacted greater in a selective manner than in a ordinary, panicky option to the news.

DOBBS: Steve?

STEVE FORBES, EDITOR, "FORBES": I suppose it's generally right. I consider the market is attaining a bottom. I suppose the more pessimism there is, the faster this issue goes to whirl round. but one of the things I consider it really is weighing on the market, it's not the spate of scandals about companies, but a artery that possibly we're not waging this struggle on terror as vigorously as they should still. I consider if they went after Iraq and seized those oil fields, I consider you'll descry the market actually flow up.

DOBBS: it's pleasing that you'd relate those two. They did occupy polls this week cautioned most efficacious 1/three of americans trust that we're really successful this war. What carry out you suppose of that concept, Mark?

MORRISON: I carry out not consider it really is bearing lots in the marketplace privilege now. I consider that the market is taking possibly some solace from the incontrovertible fact that the govt and corporate the usa seem to exist taking severely this mess this is been going on in bookkeeping and in governance. And that some severe reform goes to approach back out of this on the different conclusion. That may additionally ensnare some time, six months or a year from now. although I believe...

DOBBS: can they occupy time? I imply, it is the exciting query to me. invoice, let me question you to are available on this. can they truly occupy time? If we're drawn to restoring investor self belief, will they occupy time to celebrate this play out and to peer what number of more are out there?

O'NEIL: I suppose the difficulty is, in the event you lag through a severe correction it's extended, you should carry out something to stimulate the economic system added. or not it's extra fancy 'seventy three, '74, even a bit bit like' 29. and that i suppose that exist confident you speed up some of these tax cuts.

They may still deploy a brand unique act to give tax breaks to individuals who start a brand unique business. That doesn't suggest for whole traders, necessarily. but let americans who birth a brand unique enterprise simplest necessity to pay half the common tax, and the owners and founders and employees that personal stock, might exist after they promote the stock over the primary 10 years, to only pay half the capital features. this would birth a huge expand in unique corporations.


DOBBS: i am sorry. proceed forward, invoice.

O'NEIL: I consider you want some extra stimulus since you're going to approach out of this very slowly. you'll approach out of it, however you're now not going to approach roaring out fancy nothing ever took place.

DOBBS: Steve, your thoughts on this? greater centered investment tax credits, extra -- I can not consider about you resisting that advice.

FORBES: No, my objection could exist to the targeting. Why now not simply occupy an throughout-the-board reduce on the capital gains tax? it truly is what they did within the mid Nineties and it worked. They mustn't overlook that the so-known as booming '90s, the primary half was the worst pecuniary recovery from recession due to the fact the '20s.

DOBBS: you're fully right. it exist easy to overlook that. so that you'd want to descry it addressed via capital features. How in regards to the conception of a broader investment tax credit?

FORBES: smartly, I feel the key's for tax credit score, instead of attempting to play video games fancy they did in the early '60s with tax credit score on, tax credit score off. americans occupy received to consider here is everlasting. And relocating up, as bill suggests, the anemic tax cuts they handed ultimate summer, which are fairly small, create these efficacious now, that could champion too.

DOBBS: well, investors and the audience of this broadcast, there's a existent sense that they rep here, that americans want to descry actual outcomes. they're involved concerning the integrity of the markets. they may exist concerned about transparency. They are looking to descry righteous effects from company the us.

Mark, you occupy been speaking about the EBITDA shares, the pro forma, in case you will, businesses and shares. righteous earnings -- is there going to exist an enduring adjustment here, carry out you feel, to organizations that simply create funds?

MORRISON: I feel there goes to be. and that's one explanation why I wager i'm a bit minute bit of a very friendly information man about the WorldCom and Xerox news. I feel that this has helped shove the administration and company the usa to agree with that this become no longer only a case of a brace of defective apples, but there truly is going to should exist some severe apartment cleansing done.

And the option is, what? To shape of coast through this episode. and then they proceed again to commerce as ordinary. And a yr from now, or two years from now, we've a worse issue.

DOBBS: We're going to revert again with bill O'Neill and designate Morrison and Steve Forbes, and contend why the surprising urgency about company reform. And we'll approach to a decision -- or these three gents will approach to a decision no matter if this is the failing of the Democrats or the Republicans. reside with us.

(commercial damage)

DOBBS: We're back with Steve Forbes of "Forbes" magazine and designate Morrison of "enterprise Week" and bill O'Neil of "traders company daily."

gents, as I talked about at the destroy, they wish to find out whose failing here's, Republicans or Democrats. however first, the query that we're asking their viewers tonight is, has this market bottomed? And, bill, very instantly, has this market on your judgment bottomed?

O'NEIL: I feel it doubtless has. but when it does not, I feel the government must step up and lower some taxes and carry out a few issues, as a result of there is too lots horror and it exist been going on too lengthy. And they don't should occupy it. it's down in along what must exist the backside. And there changed into best the Nasdaq this is been exerting the actual power.

DOBBS: Mark?

MORRISON: I don't descry a bottom yet. I believe here's a undergo market and they will occupy to wait and spot. We're bumping along at low factor but valuations are nonetheless excessive. I don't descry a righteous whirl yet.

DOBBS: And, Steve, simply moments ago you used an expression, "looking for a backside." How goes the search?

FORBES: I feel if we're no longer at it, we're very immediate it. I consider traders who fancy to play timing video games should start to exist going again in. I believe we're going to occupy a rally pretty soon. The extra pessimism there is, the more advantageous the market's going to do.

DOBBS: One would hope that they would now not descry a stronger wall of fret confront us than this, or better pessimism. Who can they blame here? Mark, Republicans or Democrats?

MORRISON: actually politicians are partially in charge. They occupy been on the trip with the traders and with the accountants and with the executives. And whole and sundry, even the media, occupy been on the huge journey in the late '90s, when whole these excesses and shortcuts begun.

So, as far as Washington goes, I don't pin the blame on either party. I consider that, absolutely, the Bush folks are having to exchange their tune very dramatically as a result of their view of letting the markets carry out whole the law is not working.

DOBBS: looks fancy there may exist an hobby in some influence other than a market result, in the case of Enron, for example. invoice?

O'NEIL: smartly, the market topped in March of 2000. so you can blame it on either birthday party you are looking to. however human nature is human nature. and every sole endure market I've ever seen, every sole recession, has a few organizations proceed bankrupt, a few individuals which are doing some thing dishonest rep caught.

And the SEC does a friendly looking respectable job. at some point they'll seize each one of these individuals. So I carry out not consider that you would exist able to blame it on one birthday celebration or the other.

DOBBS: adequate, Steve? FORBES: well, I consider if you necessity to explore on the tone of the '90s, it started privilege at the appropriate, on the White condominium, where the perspective changed into anything goes. if you rep caught, spin your means out of it. The handiest component they failed to puss up to -- they could withstand everything except temptation. So it whole started at the true.

DOBBS: and how about Wall road, the investment bankers, the analysts, whole of the commerce banks assisting these deals?

FORBES: There became an attitude that there are not any greater rules, that you might shove the envelope, rep to the facet, topple off the facet. The parachute would protect you. And effects was what counted. brief- term results is what counted. And we're having the hangover.

MORRISON: They even occupy to explore at where the cash turned into coming from, from a very refined group of institutional traders who elope money for states and pension funds and the rest, who occupy been simply very chuffed to create investments in the Enrons of the world after they couldn't even exist mindful the company or the reports.


DOBBS: bill, you rep the remaining exist watchful on this thing. carry out you fancy the thought of whole these refined cash managers now suing to suitable the market's correction, in case you will?

O'NEIL: smartly, I feel the largest issue, it's unhappy for the universal public. Most traders carry out not really recognize a artery to retain money into a sound means. They carry out not truly recognize a artery to protect themselves in poorer periods. and that i'm hoping that they'll recognise this and commence trying to anatomize and exist trained more about the artery to choose shares, how to sell them, the artery to tackle them, in preference to simply accepting what anyone else says.

DOBBS: That became possibly an commandeer approach after they could watch 25 p.c profitable properties. or not it's a minute distinctive world, as you imply, invoice. invoice O'Neil, thanks for being with us. designate Morrison, Steve Forbes, recognize it.

coming up subsequent, difficult questions ahead for the us in the affray towards terrorists and radical Islamists. they will occupy the MONEYLINE "Economist" journal special document for you subsequent, in "the united states: unique directions." dwell with us.

(commercial spoil)

DOBBS: The continuing MONEYLINE "Economist" magazine collection on "American management: unique instructions." Tonight they ensnare a glance at the problem ahead for the U.S. in sustaining this affray in opposition t terrorism and radical Islamism. we're inspecting even if the usa has the will to head it on my own if integral -- politically, economically and militarily.


GEORGE W. BUSH, PRESIDENT OF the united states: nowadays, their fellow citizens, their tradition, their very liberty came below assault. DOBBS (voice-over): The president's battle on terrorism has set the stage for a unique American period. however's moreover created challenges to the USA on two fronts: to their political and military power, and to their economic energy.

The president's coalition has been strained and tenuous from the beginning. India, Pakistan, each primary participants of that coalition, and both nuclear powers, went to the brink of conflict. France, always uniquely independent in coalition, appears more aligned from time to time with Iraq.

other European international locations, together with their closest ally, Britain, at highest attribute seem to exist uneasy about U.S. coverage in the focus East.

JAMES A. BAKER III, FMR. SECRETARY OF STATE: I consider as they movement forward within the battle on terrorism, which is going to exist a protracted and strenuous combat, they will endure coalition fatigue. We're suffering it because of the Arab/Israeli conflict, we're struggling it as a result of the concerns between India and Pakistan.

invoice EMMOTT, EDITOR IN CHIEF, "THE ECONOMIST": I consider Colin Powell has it correct. He says that the crucial factor is to maintain talking, to recount your allies what you might exist doing, why you are doing it. however now not always give them a veto about what you're doing.

BAKER: The most efficacious and greatest check of a mighty vigour is the skill to carry out whatever unilaterally when your country wide hobby requires it.

DOBBS: American leadership during this unique era may require the USA to proceed it alone in accordance with the threats posed with the aid of both Saddam Hussein and Osama bin laden.

EMMOTT: I consider that to create feel of Osama bin weighted down's terrorism, you should anticipate what he'd truly supervision to carry out is to emulate Lenin. Lenin was a terrorist who became potent because he got Russia and took over Russia. Osama bin laden is simply a terrorist presently. He can handiest rep efficacious via getting Saudi Arabia or Pakistan or another country.

DOBBS: Kenneth Pollack is a former CIA defense oblige analyst. Pollack says the time for half-measures in opposition t Saddam Hussein is handed.

KENNETH POLLACK, COUNCIL ON international family members: I feel a full- scale invasion is going to exist huge. it's going to exist expensive. lots of people are going to lose their lives in it. That referred to, I carry out not consider that it might exist practically as expensive as fighting a warfare against Saddam Hussein once he has got nuclear weapons.

DOBBS: the area's simplest superpower, which is additionally the realm's wealthiest nation, will devoid of query exist stressed by artery of the rising fees of a world battle with elusive enemies. The suffuse of combating the battle this 12 months will commandeer $seventy six billion.

nonetheless, if the Bush administration wins congressional approval of its total protection funds raise, that finances will nonetheless exist near historic lows -- below half what it changed into whole over the bloodless conflict, as a percent of the U.S. low home product.

BAKER: the area has asked lots of U.S. pecuniary engine for a long time. Over the course of the past 10 years we've got been the best righteous supply of international boom.

UNIDENTIFIED MALE: Their heroes will now open the market.

DOBBS: america's pecuniary power is the basis and engine integral to pressure this war. that is why commerce scandals fancy Enron and WorldCom threaten more than simply self credit in the markets and the economic system.

EMMOTT: After the bursting of the inventory market bubble and whole of the abuses at Enron and global Crossing and Tyco, and whole of these, I suppose america's going to occupy a bumpy brace of years. privilege through that period, the usa's confidence in its ability to proceed to fund protection spending and necessity to proceed out in the world could rep dented every now and then.

DOBBS: The pecuniary costs and political dangers of this battle will exist super. however the deserve to win the warfare is essential. And so is the possibility to obtain global peace and prosperity, in keeping with natural American values of democracy and free markets.

EMMOTT: the usa has the possibility to reshape the world in quite a lot of nice techniques in the following brace of years. The query is whether or not it'll continue to occupy the incentive to carry out it and consent from the relaxation of the area. My credit is that it'll occupy each.


DOBBS: the brand unique edition of "The Economist" journal is committed to the altering position of yankee leadership due to the fact that September eleventh. known as "the usa's area on earth," it's on newsstands now.

And coming up next here, the results of their MONEYLINE poll on whether you suppose this market has ultimately hit bottom.

And, how the give artery of Enron has given three women the probability to profit from company failure. linger with us.

(industrial damage)

DOBBS: And this just in to CNN. The Walt Disney company, based on Reuters, will restate its 2000 and 2001 revenue. That in line with SEC filings. The Reuters once more reporting that Disney will restate its salary. And the explanation for that restatement, in line with those SEC filings, is a math error.

Turning now to a different setting up story, explosions heard tonight in the West bank town of Hebron. Palestinian security sources order seventy five p.c of the Palestinian complicated became destroyed. Israeli troops had been outside the complicated for a brace of days now making an attempt to negotiate the give up of Palestinians.

in the meantime, President Bush's focus East intent has met with some skepticism on the G-8 apex this week. As you comprehend, G-8 leaders agreeing with the call for Palestinian statehood. however some maxim it's as much as the Palestinians to choose their leaders. joining me now to contend this unique initiative is the former Secretary of condition Henry Kissinger.

Henry, first rate to occupy you with us privilege here.

HENRY KISSINGER, FMR. SECRETARY OF STATE: always friendly to exist with you.

DOBBS: i know you were in Europe when the president retain forward the initiative. First, what's your response? Is it a judgement behind hope?

KISSINGER: smartly, the president made pellucid that there is never one intent you could retain forward for a negotiation until you occupy got companions for you to occupy some self assurance in. and i consider that was an primary contribution.

And in the next phase, once some progress is made in that route, I consider within the next section, there could exist progress in negotiations. and i consider what must occur next is that the temper Arab countries assume some accountability for the domestic adjustments that the president spelled out for the Palestinians.

since the Palestinians aren't able to carry out it via themselves below current situations. And that means, there could exist created a negotiating partner.

DOBBS: Is it your sense that Saudi Arabia, in selected, Egypt, Jordan, occupy both the ability and the will at the second to exist a positive occupy an result on on any reform that the Palestinian Authority must endure to create it feasible for statehood, even on an meantime foundation?

KISSINGER: neatly, they've the potential. and i feel they're constructing the will to carry out that. likely they'll insist that there's some growth in negotiation -- or some negotiations being conducted. earlier than the complete manner of internal trade in the Palestinian areas is completed. however I believe that they are becoming very stressed with the occupy an repercussion on on them of the continuation of suicide bombing and turmoil.

DOBBS: And for the Israelis, the president's insistence that the settlements, the construction of settlements, cease on the West bank and in Gaza, that there exist effectively a roll-lower back to the pre-'67 warfare borders. Is that an affordable, and carry out you consider possibly productive, initiative?

KISSINGER: I suppose possibly, sure, I consider it is. I feel the president has called consideration to the incontrovertible fact that you cannot proceed from privilege here to a closing contract. You should commence through restoring circumstances by which bona fide being can birth once again.

And here is why he's entreated the Israelis to proceed back when the Palestinians occupy made their adjustments, to the situations that existed when this complete cataclysm whole started. And additionally to conclusion any unique condense undertaking. I suppose here's an inexpensive foundation on which to commence negotiations.

DOBBS: Dr. Henry Kissinger, thank you very a whole lot for being with us, as at whole times.

KISSINGER: delectation to exist on.

DOBBS: Let's ensnare a quick explore now at the effects of their MONEYLINE ballot. Tonight's query: carry out you believe that this inventory market has ultimately hit bottom? Twenty % of you said yes, 80 percent said no. And, while now not scientific, a objective indication. and that i must order that the market doesn't appear to exist arguing with the effects of this poll.

arising next, the "Dobbs document." a brace of innovations about the rising political temperature and posturing in Washington about corporate scandals. linger with us.

(business break)

DOBBS: well, after the scandals at Enron, three enterprising former Enron ladies occupy decided to ensnare odds of their adversity through making an attempt to enrich their fortunes, performing in "Playboy" magazine. and that they're cashing in by far neatly in a whirlwind media tour which has led them, of course, to unique york metropolis. and they are, in case you exist interested, appearing in the August situation of "Playboy" magazine.

neatly, Enron, international Crossing, Tyco, ceremony help, Qwest, Adelphia, ImClone methods, now WorldCom -- the Democrats occupy create a crusade subject, company abuse. The Senate majority leader says the challenge will play in each condition this November. Tom Daschle nowadays charged that the Republicans -- quote -- "dismantled the regulatory atmosphere they had and, in significant measure, created the sense of laissez faire," conclusion quote.

Even Al Gore wants to play, asserting at a fund raiser here in long island this week that the president's tax guidelines resemble the outbreak of accounting fraud.

I carry out not necessity to exist a spoilsport here, however did both Mr. Gore or Senator Daschle note that these multibillion greenback company restatements proceed back to 1997? That the telecommunications act turned into 1996?

And now, of route, President Bush needs to station them in penal involved and the treasury secretary wants to hang them excessive. George Bush and Paul O'Neill talking about company criminals, now not the Democrats. The president is siccing the Justice offshoot on the perilous guys and the SEC is investigating just about every most primary enterprise within the nation.

once again, I carry out not want to exist a spoilsport privilege here, however does the Bush administration neglect that it's been supporting Senator Phil Gramm's efforts to cease accounting and corporate reform on Capitol Hill for months now?

Do the Republicans and the Democrats both understand that the American investing and balloting public is watchful that or not it's been six months since Enron went bankrupt, and not a thing of those condo or Senate investigations -- of which there had been a dozen -- occupy amounted to the comfort to this element? That there were no fees introduced towards a sole Enron executive?

If the Republicans and the Democrats are thinking about reform now, ultimately, then their movements will occupy to exist as a minimum as energetic as their shove rhetoric.

this is MONEYLINE for this Friday night. Thanks for being with us and occupy a extremely pleasing weekend. For everyone here, respectable nighttime from mighty apple.

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SP Video aspect III Wireline

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Puma Biotechnology, Inc. (PBYI) CEO Alan Auerbach on Q2 2018 Results - Earnings call Transcript | existent questions and Pass4sure dumps

No result found, try unique keyword!As investors are aware, they occupy an ongoing aspect III trial of neratinib in third-line HER2-positive ... from physicians and moreover as you know there is a lot of these online videos that physicians post ...

ASCO GU 2019: Results of a 50 Patient Single-Centre aspect II Prospective trial of Lutetium-177 PSMA-617 Theranostics in mCRPC | existent questions and Pass4sure dumps

San Francisco, CA ( PSMA is over-expressed in whole prostate tissue, including prostatic carcinoma. Lutetium-177 (177Lu)-PSMA617 (LuPSMA) is a wee radiolabeled molecule which binds to PSMA and delivers a dose of β radiation. Lutetium-177 is a friendly partner to encourage deliver the radiation because of the short orbit β radiation (maximal tissue penetration of <2mm), thereby decreasing the potential collateral damage to nearby organs. 

The authors of this study occupy previously reported on their suffer of 30 men with metastatic CRPC treated in a single-center aspect II prospective trial of LuPSMA.1 This abstract represents an updated analysis of an extended cohort of 50 patients.  

In this aspect II trial, 50 men with PSMA-avid (defined as elevated PSMA expression in at least one site of metastatic disease with > 1.5 SUV of the liver) mCRPC who had progressed after gauge therapies (including docetaxel and androgen-axis targeted therapies) received up to 4 cycles of LuPSMA every 6 weeks. The replete protocol can exist seen below: ResultsSchema_177LuPSMA.png

The primary endpoints were PSA response (according to PCWG2 criteria) and toxicity (according to CTCAE v4). Secondary endpoints included imaging response, PSA PFS and OS. 

75 men were screened to identify 50 patients eligible for treatment. Median PSA doubling time was 2.6 months. The majority of patients had received prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (90%). replete demographic info is seen below:PatientDemographicInfo.png

These men are heavily pretreated mCRPC patients with limited alternative options. The mean administered radioactivity was 7.5 GBq/cycle.  

In terms of response, PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with a PSA decline ≥ 80%. Best PSA response is depicted here: BestPSAResponse_ASCOGU.png

27 patients had measurable soft tissue at baseline and 56% of these patients had a partial or complete response by RECIST 1.1 criteria.  

Median PSA PFS was 6.9 months (95% CI 6.0-8.7) and median OS was 13.3 months (95% CI 10.5-18.0). Upon subsequent progression, further LuPSMA was administered to 14 patients (median 2 cycles commencing 359 days from enrolment); PSA ≥ 50% response occurred in 9 patients (64%), indicating the option for retreatment. 

The PFS KM curve:PFS_KM_Curve.pngPatients who had a >= 50% response had a PFS of 8.3 months. 

OS K-M curve seen below:OS_KM_Curve.pngMen who had a >= 50% PSA response had a median OS of 18 months.  

Overall, LuPSMA was well tolerated. The most common toxicities attributed to LuPSMA were transitory G1-2 dehydrate mouth in 68%, G1-2 nausea in 48%, and G1-2 fatigue in 36%. G3-4 toxicities attributed to LuPSMA were infrequent with thrombocytopenia in 10% and anemia in 10%.  

Using this expanded 50 patient cohort confirms elevated response rates and low toxicity with LuPSMA in men who had progressed after gauge therapies. In patients who subsequently progressed and were administered further LuPSMA, elevated response rates were moreover observed, indicating that this treatment can exist repeated with significant response. These results occupy provided the basis for randomized controlled trials currently underway – the ANZUP/PCFA TheraP trial (Lutetium-PSMA vs. cabazitaxel) and the Endocyte VISION trial.  

Presented By: Michael Hofman, FRACP, MBBS, nuclear medicine physician in the Centre for Cancer Imaging at the Peter MacCallum Cancer in Melbourne

Written by: Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University; Twitter: @tchandra_uromd, @JEFFUrology at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium, (ASCO GU) #GU19, February 14-16, 2019 - San Francisco, CA


  • Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, aspect 2 study. Lancet Oncol. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Epub 2018 May 8. 

  • Fujifilm X-A5 Unveiled as Smallest & Lightest X train Mirrorless Digital Camera | existent questions and Pass4sure dumps

    FUJIFILM unveiled today the Fujifilm X-A5 as the smallest and lightest X train zoom lens kit mirrorless digital camera featuring recently developed sensor and color reproduction technology.

    Sporting a 24.2MP APS-C sensor with 1.5x crop factor that features a aspect detection autofocus system and Fujifilm's latest image processing engine capable of offering processing speeds of up to 1.5 times faster than previous models, Fujifilm X-A5 offers higher ISO sensitivity of ISO12800, more accurate scene recognition in SR+ AUTO mode, 4K movie recording, a 180 degree tilting rear LCD with palpate screen, and Bluetooth support.

    "Combined with Fujifilm's renowned outstanding image attribute with the company's proprietary color reproduction technology, the X-A5 is compact, stylish and portable making it the example companion for everyday photography," says Fujifilm in today's announcement. "The X-A5 combines a newly developed 24.2 megapixel APS-C sensor with the image processing engine to achieve Fujifilm's renowned photo quality."

    The first X-A train model to feature aspect detection pixels

    Fujifilm X-A5 is moreover Fujifilm's first X-A train digital camera to feature aspect detection pixels, which can exist create only in the high-end X train models. Also, Fujifilm X-A5 includes the first electric-powered zoom lens for the X Mount, the FUJINON XC 15-45mm (23-68mm in 35mm format) f/3.5-5.6 OIS PZ, which Fujifilm says it's perfect for photographing human subjects, but moreover for capturing those "can't-be-missed" moments on your holidays.

    Also noteworthy is that Fujifilm X-A5 integrates an smart Hybrid AF that's twice as quick as in previous models so you won't miss any crucial photographic moment, as well 11 variations of Fujifilm's unique Film Simulation Modes, including the unique "HDR Art" and "Fog Remove." eventual but not least, Fujifilm X-A5 incorporate the latest Bluetooth Low Energy technology for easy pairing with Fujifilm's Camera Remote app for iOS and Android.

    Fujifilm X-A5 is moreover compatible with the FUJIFILM Instax partake SP-3 printer and offers a High-Speed HD Video role and unique 4K video capabilities. A unique battery was included as well in this model, promising to allow you to shoot up to 450 photos per sole battery charge. Fujifilm X-A5 weighs only 496g, which makes it the perfect camera for travel photographers. Fujifilm X-A5 costs $600 USD and it's available in Brown, Silver, and Pink colors.

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