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644-344 exam Dumps Source : SP Video phase III Wireline

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Evolution of Key Cisco leadership Positions | killexams.com real Questions and Pass4sure dumps

Cisco’s lengthy-standing perception has bar None the time been that groups should evolve to pressure forward and lead through market transitions.  The equal is revise for their government skill.  Evolving their talent requires putting them in new roles, increasing their perspective and skill sets and bringing fresh ideas and energy to the company. here's what we’ve these days performed with Edzard Overbeek’s new stream from SVP of their Asia-Pacific-Japan region to plug of their international capabilities company and Bruce Klein’s circulate from SVP of Public Sector sales to the pinnacle of their international associate organization.

during the final yr, they bear refocused their engineering organization for agility, more advantageous determination making, and a renewed focal point on innovation.  The market participate numbers converse for themselves and their consumer self faith has by no means been enhanced.  we've a powerful leadership group and the enterprise community leaders bear tested powerful execution.  Now the time is revise for us to drive the next section of their organizational evolution.

With that, we're blissful to promulgate Padmasree Warrior will extend her office to develop into Cisco’s Chief technology and approach Officer where she should live chargeable for settling on consumer and trade transitions and selecting Cisco’s approach to address them.  Padma will toil intently with Cisco’s engineering, container, operations and services management, and may contour strategy, investments, acquisitions and the evolution of Cisco’s know-how companion ecosystem.   additionally, Padma may live liable for idea leadership around Cisco’s products and architectures, technical skill structure and recruiting, and she or he will raise her time with external stakeholders.  The trade group CTO’s will document dotted line to Padma to allow powerful alignment between technology approach, enterprise method and M&A pastime.  during the final 4 years, Padma has based a major tune record of results, corresponding to constructing Cisco’s method and execution round architectures, cloud, gardenvariety expertise approach framework, and attracting and developing trade main technical talent.  They stare forward to accelerating their market position beneath Padma’s strategic course.

After 13 years of outstanding provider to Cisco, Ned Hooper should live leaving the instant Cisco family to configuration an impartial funding partnership trade and to pursue his end to live a primary investor.  Ned has been engaged on his map with us over a few months, and they seem forward to partnering with him in his new activity.  Ned has a discrete passion and skill for funding and approach, and may seat of attention on this in the subsequent Part of his profession.   Ned pioneered the mannequin for gigantic-scale M&A at Cisco and drove giant transactions for the enterprise corresponding to Tandberg, WebEx, Airespace, Starent and NDS.  additionally, he has managed their $2B funding portfolio with each strategic and economic returns to the business. Ned’s strategy and company structure group will now document to Padma.  they would want to thank Ned for his contributions, leadership, friendship and his persistent obligate to at bar None times achieve the birthright issue for Cisco.

ultimately, Pankaj Patel will assume the management of Cisco’s engineering organization.  Pankaj will obligate innovation, operational excellence and agile construction throughout their products, options and architectures, and continue to enhance their relevance with their expanding customer base.  Pankaj’s abysmal client relationships and extensive engineering capabilities, combined together with his skill to mentor and grow properly engineering skill will serve Cisco well as they obligate the subsequent section of engineering management for the business.  when you could live accepted with Pankaj’s carrier company adventure, he previously spent sixteen years in the commercial enterprise area.  over the final 13 years, Pankaj developed and grew Cisco’s carrier company trade which today money owed for about 35% of Cisco’s direct product earnings. Pankaj’s leadership in key service issuer areas corresponding to core routing, Part routing, SP mobility and SP video has positioned Cisco extremely smartly for the long run. bar None the passage through his tenure Pankaj has delivered a significant number of products to the Cisco portfolio, addressing a wide array of customer needs.  over the final 12 months because the co-leader of engineering, Pankaj has accelerated his involvement in Cisco’s commercial enterprise company, as the intersection points between service provider and commercial enterprise approach closer together.

As they dwell focused on being the most fulfilling Cisco for their valued clientele, companions, buyers and personnel nowadays, they in no passage lose song of the Place they wish to Go sooner or later.  we're excited about this evolution in their corporation. tickle live a Part of us in congratulating Padma, Pankaj and Ned on the next phase of their respective journeys.

John Chambers and Gary Moore

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CNN LOU DOBBS MONEYLINE | killexams.com real Questions and Pass4sure dumps

here's A RUSH TRANSCRIPT. THIS copy may additionally now not live IN ITS remaining configuration and can live updated.

this is A RUSH TRANSCRIPT. THIS replica might too now not live IN ITS final configuration and can live up-to-date.LOU DOBBS, HOST: Tonight, President Bush puts corporate the usa on note: shape up or visage the Justice department.

Democrats accuse the president and Republican lawmakers of being too soft on corporate abuse.

we'll bear are vital reviews for you from the White condo and Capitol Hill.

WorldCom's CEO sends a letter to the president promising cooperation and reform.

Xerox admits it made a $4-billion mistake however says, nonetheless, it isn't any WorldCom.

we'll bear a discrete report there as neatly.

The Arizona wildfire is even better tonight. or not it's damaged through fireplace containment strains. Two further towns tonight are in jeopardy.

And former Enron personnel at the flash are the women of "Playboy" journal.

ANNOUNCER: here's LOU DOBBS MONEYLINE for Friday, June twenty eighth. birthright here now Lou Dobbs.

DOBBS: respectable night.

President Bush nowadays lashed out against company misbehavior. Mr. Bush referred to groups need to raise the bar and never fudge their numbers. day after today, the president will use his radio address to induce company leaders to limpid up their acts.

we now bear two studies tonight. They start with Kate Snow on Capitol Hill and Senior White house Correspondent John King.

John.

JOHN KING, CNN SENIOR WHITE residence CORRESPONDENT: neatly, Lou, the president may live speakme about this theme more and more in the days ahead. You mentioned the radio exploit the following day. The president will once again press corporate leaders to disclose accountability, double-determine their accounting practices.

Mr. Bush too will Go back and forth to new york metropolis on July 9th, CNN is advised, and convey a speech dedicated entirely to the theme of company responsibility.

The White apartment seizing on this story, making an attempt to pick up the initiative. Mr. Bush announcing the government is looking at what it might achieve administratively. he's urging the Congress to recall a glance at disclosure rules as well.

Mr. Bush asserting he's concerned about this theme not only as a result of the circumstances of WorldCom and Enron, but he believes it's inflicting a slowdown in client -- a scarcity of purchaser self faith in the stock market and having an impress on the universal U.S. economy.

(begin VIDEO CLIP)

GEORGE W. BUSH, PRESIDENT OF the U.S.: corporate the united states has bought to bear in intellect there's a much better calling than making an attempt to fudge the numbers, trying to skid a thousand million here or one billion there and hope nobody notices.,

but you've got a accountability in this country to bar None the time live above board. They hope excessive requirements in their faculties, they are expecting excessive standards in company the usa as smartly, and i intend to implement the legislations to live confident that there are elevated specifications.

(end VIDEO CLIP)

KING: The White apartment realizing this is not just a coverage debate but additionally a political debate. Democrats making the case in this midterm election 12 months that the president and his Republican birthday party are guilty for lax law, are too cozy with huge enterprise. The White apartment says Mr. Bush is determined to pick up out forward on this one and never let Democrats yield that case.

Lou.

DOBBS: John, the president calling upon Congress to behave birthright here. The White condo has been helping Senator Phil Gramm's efforts to desist reform of accounting and company reform on Capitol Hill. How does this bar None rectangular off?

KING: smartly, definitely, when you consider that the Enron disclosures and now the WorldCom disclosures, the White condo is asserting that it's asking the SEC Chairman Harvey Pitt to achieve greater administratively and says it's going to thrust in the Congress.

however you might live precisely confiscate in that some Democrats on Capitol Hill command there are as a minimum inconsistencies, some command hypocrisies, within the administration's approach. bar None this now a Part of a political debate in this midterm election year as well as a extremely reputable policy debate over simply precisely the Place is the role of government in telling company the us the passage to govern itself.

And, John, the president is undergoing a colonoscopy this weekend. Any word as to why he is going to live below sedation during that examination?

KING: His doctors suggested this, Lou. The method may too live extremely uncomfortable. Mr. Bush has had two during the past wherein benign polyps were eliminated. His docs command he was sedated at the remaining one.

they say, #1, sedation minimizes discomfort on the patient. And, quantity two, they are aphorism it makes it workable for then the doctors to achieve a greater thorough job as a result of, if the affected person is uncomfortable, the medical doctors are likely to rush the technique.

all and sundry birthright here at the White residence aphorism here is a really hobbies process for the president to try this. He has no signs in any respect. he's in wonderful health, his medical doctors say.

but he will temporarily switch power to the vp. Mr. Bush says it is a wartime precaution, anticipating Dick Cheney could live appearing president of the united states someplace within the region of one to three hours day after today.

Lou.

DOBBS: ok, John. thanks very a mighty deal.

Senior White condo Correspondent John King.

Democrats, as John reported, try to profit political abilities from these corporate scandals. nowadays, Senate Majority chief Tom Daschle referred to company corruption is threatening the pecuniary system, and Daschle accused Republicans of backing policies that led to company misbehavior.

For more on the story, i am joined by passage of Kate Snow on Capitol Hill.

Kate.

KATE SNOW, CNN CONGRESSIONAL CORRESPONDENT: Lou, Tom Daschle additionally said that he's heard from a lot of CEOs over the closing pair of weeks, and he stated they participate his outrage over things devotion WorldCom. He says they respect as an Awful lot as they do, lawmakers do, that, in Daschle's words, there may live bought to live a change within the legal guidelines, the legal guidelines deserve to live reinforced.

He changed into very limpid that you simply can't withhold the only vice on the Bush administration for WorldCom's failure, but he does command that he believes, quote, "a laissez-faire attitude during this administration has helped create the benevolent of ambiance that exists these days."

(begin VIDEO CLIP)

SEN. TOM DASCHLE (D-SD), SENATE MAJORITY leader: there may live too a mighty deal executive rules. there is too a superior deal govt involvement within the corporate sector. And what they want now's to eradicate government and bar None of its presence from any oversight obligations.

And, piece by piece, they dismantled the regulatory ambiance that they had and, in colossal measure, created this sense of laissez- faire, of just total unwillingness on the a Part of enforcement or regulatory corporations to play a job.

(end VIDEO CLIP)

SNOW: Now, obviously, Democrats are seizing on this concern, hoping that it might profit them some votes this topple in the election.

whereas some Democratic strategists bear observed they're now not going to live gleeful about americans dropping jobs, not at all, an additional strategist did command to me this turned into a fortunate ruin, this WorldCom story.

condominium Democratic chief Dick Gephardt being even a diminutive more forceful, a bit more political than Tom Daschle became. He observed -- he cautioned that it was the past eight years of condo Republican exploit -- Republican exploit of the apartment of Representatives -- that has brought about one of the vital issues because they did nothing about corruption.

And, nowadays, a Republican shot back, invoking bill Clinton's legacy.

(begin VIDEO CLIP)

REP. WILLIAM THOMAS (R), CALIFORNIA: if you wish to learn a mannequin for individuals now not behaving morally -- or the style of aphorism it is: achieve the revise factor even when individuals don't seem to live watching -- I suppose you will locate that the Oval workplace has a all lot more similarity to the board margin than the ground of the house of Representatives.

if you're hunting for someone who set the ethical tone for the decade of the '90s, I achieve not reflect you need to seem any farther than the previous president's habits.

(end VIDEO CLIP)

SNOW: And Republicans command they are equally upset about what's took Place at WorldCom, they too want action, but they with ease don't perceive it as a political issue, Lou.

they command that if Democrats are going to are attempting to play up the diminutive man versus the potent during this crusade season, this operative observed, well, perhaps it will toil simply as smartly as it did for Al Gore.

Lou.

DOBBS: bar None appropriate, Kate. One query on this. Tom Daschle, gleeful or now not, regarding the laissez-faire attitude in rolling lower back regulation. The Telecommunications Reform Act of 1996 become signed by bill Clinton. How does that...

SNOW: i am unavoidable Republicans will factor to that too, and they have. They've spoke of, "appear, you can not command that the previous eight years has been totally below Republican control. You had President Clinton within the White condo."

They've made that aspect time and again when this has approach up. and that they've additionally said, you know, for a short time -- smartly, the Senate's been in exploit now for a short time of the Democrats. What about that?

Lou.

DOBBS: adequate. thank you very a all lot.

Kate Snow reporting from Capitol Hill.

The parole board in California that has been due to the fact whether to liberate an infamous Manson friend who's serving lifestyles in detention seat for her role in killing sprees in 1969 -- Leslie Van Houten become 19 on the time.

here is a reside photo of Leslie Van Houten. She become 19 at the time of those killings. She has faced a parole board 13 times. each and every time, she's been turned down. Her parole again has been turned down.

Let's hear in.

(begin VIDEO CLIP)

UNIDENTIFIED CALIFORNIA PAROLE BOARD MEMBER: She, although, had been arrested for auto theft. They had been no longer interestingly prosecuted. however she did bear prior criminal activity in that she became a drug consumer, together with LSD, marijuana, methadrine, mescaline, and benzadrine, and this drug use had been happening for at least a pair of years.

(end VIDEO CLIP)

DOBBS: This, the California Parole Board, denying Leslie Van Houten, a member of the notorious Manson family unit gang, once more for a 14th time being denied a request for parole, and her existence sentence continues.

"surprise" and "outrage," the words used via WorldCom's chief executive officer, John Sidgmore, in a letter to the president these days.

Sidgmore talked about he became bowled over by passage of the invention of a $4-billion fraud at his company. He additionally outlined changes he's making in WorldCom's enterprise practices, and, among those, 17,000 layoffs that begun today.

Sidgmore additionally pledged plenary cooperation with the a number of investigations of WorldCom.

And, in the meantime, a Mississippi umpire has issued a restraining order that bars WorldCom, its auditors, and its personnel from destroying files. The elect too stated he would nominate a computer screen to oversee doc retention. An SEC order this week simplest advised that documents live preserved.

yet another accounting scandal at Xerox. Xerox will recall out virtually $2 billion of profits that it already suggested. An audit confirmed that Xerox posted these revenues earlier than they were in fact made.

Bruce Francis has the file.

(begin VIDEOTAPE)

BRUCE FRANCIS, CNN CORRESPONDENT (voice-over): Xerox admits that again in the late '90s, it robbed the longer term to yield the latest seem improved than it in fact become. The company is revising five years of outcomes.

Xerox needed to restate its financials after settling expenses with the Securities and change commission again in April and paying a $10- million satisfactory.

In a press release, CEO Anne Mulcahy said Xerox these days closes a tough chapter in the business's background. Mulcahy declined to live interviewed for their story.

score the inventory a purchase for the judgement that November, Peter Ausnit thinks that Xerox can turn round.

PETER AUSNIT, DEUTSCHE pecuniary institution SECURITIES: They perceive Xerox as a corporation that can earn a substantial amount of cash over the next pair of years, peculiarly when enterprise conditions normalize.

FRANCIS: but traders, certainly folks that purchased Xerox birthright through the late '90s, could no longer learn it so smooth to overlook Xerox's inaccurate accounting.

As Part of its restatement, Xerox now admits it should bear booked much less earnings in 1997, 'ninety eight, and '99, a time when the inventory was taking off. however the company insists that the sales -- in this case, gadget leases -- are actual and that the revenue from the late '90s really belongs in 2000, 2001, and past. for instance, 2001 finally ends up searching superior than earlier than by using half one billion dollars.

The base line $1.9 billion may live taken out of revenues already mentioned.

but the writer of "How organizations Lie" says achieve not lop what Xerox did.

RICHARD SCHROTH, creator, "HOW groups LIE": I don't consider it's a small, diminutive accounting oversight in any respect. companies devotion Xerox and others who bear been named to the Fortune 100 greatest businesses and other such -- bear a accountability to live brazenly heedful on these forms of things.

(conclusion VIDEOTAPE)

FRANCIS: neatly, former Xerox auditor KPMG maintains that they bear been careful, inserting out a press release these days standing via its prior toil with Xerox and calling the copier business's restatement an unbelievable about-face.

Lou, they're on the fence. DOBBS: The auditor now not agreeing with the restatement.

FRANCIS: now not agreeing with the restatement, no longer agreeing with Xerox, no longer agreeing with the SEC, not agreeing with PricewaterhouseCoopers.

DOBBS: And they bear now seen loads of margin for disagreement, however it does yield you marvel how anybody can command they were cautious when there may live an controversy of $2 billion.

FRANCIS: elevated priced selections that cost traders some huge cash, Lou.

DOBBS: And we're, unfortunately, getting used to lots of these choices that can charge traders some huge cash.

Bruce, thanks a all lot.

stocks closed diminutive modified on the day despite the latest scandal. today marked the conclusion of the 2nd quarter. That quarter noticed main indexes register double-digit losses.

nowadays, the Dow Jones Industrial typical fell more than 26 aspect. The Nasdaq rose pretty much 6 features. The S&P 500 dropped virtually a degree.

Jan Hopkins could bear finished market coverage for us in just moments.

Tonight's MONEYLINE quick vote query is concerning the markets. we'd devotion to live sensible of: achieve you consider that this inventory market has at final hit backside? that you could cast your vote by means of going to cnn.com/moneyline -- cnn.com/moneyline -- and while you're there, which you can bar None the time ship us an electronic mail as well. they are going to bear the outcomes of tonight's vote later in the broadcast.

We additionally want to recall this probability to recall a stare at your recommendations on corporate scandals. Susan Christie writes in to assert, "With Enron, Arthur Andersen, and now WorldCom, the phrase 'Figures not ever lie, however liars at bar None times figure,' became on no account extra actual."

John DePetris, "Why should al Qaeda map greater assaults when we've Enron, WorldCom, Xerox CEOs, CFOs, et cetera, doing what the terrorists would dream of doing? it is destroying the American pecuniary market."

And Brian Scott of Canada says, "Is it any examine yourself that current anti-globalization protesters don't bear any faith in the present capital system. bar None they perceive are thieves, cheats, and liars whose best pastime is to complement themselves on the fee of traders and personnel."

we are going to bear greater of your options later in the broadcast. And, as bar None the time, which you could e-mail us at moneyline@cnn.com. And they at bar None times examine that you simply include your identify and address.

Let's flip now to these wildfires raging within the western a Part of the nation. a brand new hazard tonight in Arizona. That large hearth nigh the city of demonstrate Low, Arizona, has broken via a containment line, threatening a nearby subdivision.

Thelma Gutierrez has greater on the tale for us.

Thelma.

THELMA GUTIERREZ, CNN CORRESPONDENT: Lou, at this time, what's going on is that firefighters are working to establish a fireplace line to thrust that fire again. The wind has kicked up a diminutive bit in exactly the past few minutes, which is not a superb factor obtainable.

additionally remaining nighttime, the fireplace had moved down the back aspect toward the city of Heber. Firefighters working day and night to try to dangle these hearth lines to reclaim these communities. they bear got felt and that they mentioned past nowadays that, if they're able to hold those strains through the day, they'll bear an excellent probability of saving the communities.

Now, nowadays and the following day, the crimson plug and indigenous officials bear begun what they bear got called van tours for residents who misplaced their buildings. The residents will most effective bear a casual to view their properties. as a result of safety concerns, they will not live allowed to in reality pick up off and Go into their property. And officers bear mentioned that on account of the fine nature of these tours, cameras aren't allowed in.

Now, to date, 419 acres of Ponderosa pines bear burned up here in the disclose Low enviornment, and more than 50 p.c of the land that has burned is on the Apache reservation land that has had a devastating impress on tribal individuals. up to now, they command that two sawmills bear now closed down. three hundred jobs out here could live lost. the all estimated cost of the bushes they bear got lost: $237-million.

(start VIDEO CLIP)

LUCI BENALLY, APACHE TRIBE MEMBER: i am hoping that bar None and sundry is sensible of that now not best achieve americans within the demonstrate Low and Pinetop areas stand to lose their homes, however their tribe has lost so a all lot and too much. We're speakme thousands and thousands and thousands and thousands and tens of millions of bucks in an worry to on no account live replaced in their lifetime.

(end VIDEO CLIP)

GUTIERREZ: A spokesperson for the Apache tribe advised me a short while ago that it'll a century earlier than they're in a position to pick up better from this fireplace, Lou.

DOBBS: Thelma, thank you very much.

Thelma Gutierrez from demonstrate Low, Arizona.

well, officers in Colorado are hoping that calmer weather will assist their combat in opposition t wildfires. Two fires nigh Durango, Colorado, bear burned more than 70,000 acres and destroyed dozens of homes. these fires are best a 3rd contained.

in the meantime, an almost a hundred and fifty,000-acre hearth near Denver may noiseless live absolutely beneath manage via Sunday.

coming up tonight, the markets grappling with a surge in earnings restatements by passage of corporate the us. we'll investigate the competencies for extra surprises forward.

Wall highway, as soon as the envy of the area. Now lots of the world is questioning their mannequin of capitalism. they are going to bear that record for you.

we will verify the problem that the united states faces in sustaining the battle towards terrorism and radical Islamists in their MONEYLINE "Economist" magazine string on American management, New directions.

And Henry Kissinger will live birthright here to examine the us's peace efforts in the core East.

All of that and more nevertheless forward. live with us.

(industrial damage)

DOBBS: Two foremost enterprises came forward to yield imposing restatements of their prior outcomes this week. The query nobody can reply tonight is how many more restatements are there.

Peter Viles has the story.

(begin VIDEOTAPE)

PETER VILES, CNN CORRESPONDENT (voice-over): As one-two punches go, this turned into an enormously expensive mixture. WorldCom, then Xerox, $6 billion worth of crummy accounting. The number of company revenue and salary restatements had already been rising, spiking an Awful lot extra sharply in the synchronous economic downturn than it did in the ultimate one.

So the query traders are asking: is this the top or just the beginning? naturally, the SEC isn't able to declare victory on bogus bookkeeping.

HOWARD SCHILIT, seat FOR fiscal analysis & evaluation: The toil of the SEC is beginning to rule upon up pace. they bear anything devotion 65 existing investigations. The SEC just bought a large raise in their funds. and that i suppose the power continues to live on the SEC and different regulators to limpid up the mess.

VILES: The SEC final nighttime took motion so one can obligate CEOs to swear, beneath oath, to the accuracy of profits stories, a troublesome step meant to flush out any accounting scandals that are hiding in corporate books.

LYNN TURNER, FORMER SEC CHAIRMAN: Harvey Pitt has to plug a step additional and say, "now not most effective achieve I wish you to signal on the final analysis birthright here in case you ship for your subsequent set of economic statements, but you need to recall if those discontinuance up incorrect, we're going to demonstrate round and ship you to penitentiary." VILES: that is a superb point, however Harvey Pitt has been there and spoke of that. here's what he referred to this week when asked what happens if these sworn declarations become false?

HARVEY PITT, SEC CHAIRMAN: You Go to prison since it's fraud if you certify it and it live false.

(conclusion VIDEOTAPE)

VILES: In light of this arduous talk from the SEC, there is a few hypothesis they may too in reality perceive greater restatements within the coming weeks than they might bear otherwise.

corporate the united states basically has six weeks to pick up its books so as. Then beginning in mid-August CEOs will ought to swear below oath that these books are the fact.

Lou.

DOBBS: it live a shame that it live approach to this, but Harvey Pitt's thought birthright here in terms of signing and swearing to those fiscal statements -- it may possibly become the solution here or a imposing Part of it.

VILES: it's a means to yield everyone say, "Come ahead. bar None those that haven't committed accounting fraud, step ahead." It turned into the president's conception initially.

DOBBS: adequate. Pete, I recognize it. thanks.

The scandals sweeping throughout corporate the usa are elevating massive questions in regards to the effectiveness of the mannequin of capitalism, its apply during this nation. international buyers, some of them, are reluctant to withhold are withhold their cash during this country, and American accounting practices are being challenged as on no account earlier than.

Kitty Pilgrim has the story.

(begin VIDEOTAPE)

KITTY PILGRIM, CNN CORRESPONDENT (voice-over): For years, the American company mannequin turned into touted because the most useful on earth, U.S. prevalent Accounting principles advanced, and corporate governance probably the most advanced. With debacles at Enron, ImClone, Tyco, and Adelphia dominating U.S. headlines, Europeans are starting to gloat.

"In the usa, bar None that glitters isn't gold," Deutsche bank's former CEO Rolf Breuer mentioned in a speech this week. however the usa's gadget become golden for a long time and had the numbers to demonstrate it. Unemployment lessen than in Europe, capital markets within the U.S. outperforming Europe, bigger productivity numbers, and a stalwart greenback.

but now the dollar has fallen about 10 percent towards the euro up to now this yr. Markets are foundering, and the enormously touted accounting necessities being reexamined under a congressional microscope, satisfactory to yield the White apartment retreat the American method.

ARI FLEISCHER, WHITE condo SPOKESMAN: The president believes that america's free commercial enterprise device is a system this is performed very well for the American people, or not it's resulted in lots comfort, or not it's resulted in a stalwart culture for the American americans.

PILGRIM: And a glance on the markets indicates, over the final two years, the Dow held up more suitable than stock indexes in Frankfurt, London, and Paris, down 28, 38, and forty two p.c respectively.

Some component out the U.S. company mannequin is always evolving and improving from its missteps.

ROBERT SCHILLER, YALE college ECONOMIST: From decade to decade, they live trained further and further about how to rush organisations, but a Part of the technique contains experimentation, and experimentation has unpredictable penalties, and some undesirable consequences, and so they are -- from one decade to the subsequent, they bear to straighten out these blunders as neatly.

(end VIDEOTAPE)

PILGRIM: So, during the past few months, there were changes in the passage removed places companies are operating, and Europeans are now pushing for more unbiased board contributors and superior transparency, and the CEO incentives are too being reexamined. briefly, the becoming pains are being felt bar None around.

Lou.

DOBBS: but nevertheless free markets and freedom. it's working.

PILGRIM: or not it's working, and...

DOBBS: a bit uneven every now and then.

Kitty, thanks plenty.

Kitty Pilgrim.

nevertheless forward here, the final Part of their collection with the "Economist" magazine. Tonight, they seem to live at the challenges dealing with the united states in sustaining the battle towards radical Islamism and terror.

Blue chips fizzle on the ultimate day of the 2d quarter. The NASDAQ ends significantly greater, however a tough quarter it become. we'll live telling you about that.

And the women of Enron display their talents with the assist of "Playboy" journal.

All of that and greater nonetheless forward. dwell with us.

(industrial smash)

DOBBS: shares closed the 2nd quarter diminutive changed on the day despite this newest accounting information from Xerox.

Jan Hopkins has the marketplace for us now.

Jan.

JAN HOPKINS, CNN CORRESPONDENT: Lou, given bar None of that, it was no longer a detestable displaying for shares.

The market in reality brought to yesterday's rally. but the Dow did slip into negative territory simply earlier than the closing bell when the president announced he would transfer power to the vice president birthright through his colonoscopy tomorrow at Camp David.

For the day, the Dow become down, and it became down for the sixth week in a row. Nasdaq ended the day and week better. The S&P slipped just a little.

Christine Romans is at the new york stock exchange, and Greg Clarkin is on the Nasdaq.

Christine?

CHRISTINE ROMANS, CNN CORRESPONDENT: well, Jan, another unstable day and two-billion shares traded today to nigh this quarter.

Xerox, as you'll predict, lost 13 p.c because of that restatement, however NIKE soared after mighty fourth-quarter earnings. Auto shares rallied today on hopes for a rebound in June motor vehicle earnings. And Philip Morris won after a horrific week. it live nonetheless down sixteen % this quarter, though. Tyco additionally gaining these days on excessive hopes for its CIT IPO.

however it's been a Awful quarter for Tyco, down fifty four %. recall a glance at AOL, parent of this community, AT&T, IBM, and GE, bar None generally held stocks, bar None struggling acute percent losses over the past three months.

Now to the NASDAQ and Greg.

GREG CLARKIN, CNN CORRESPONDENT: And, Christine, relatively reticent day for word in huge identify tech shares.

Take a stare returned on the quarter. perceive how those massive cap know-how shares fared. recall a glance at sun Microsystems down virtually forty three % for the 2d quarter. Intel down pretty much forty percent. Oracle dropping virtually 26 %. You had Cisco with a 17-percent loss. Microsoft down 8.6 percent.

but you are looking to dispute steadiness? How about Dell computing device? It bar None started the quarter trading at $26.11. It ends the quarter trading at $26.14. That three-penny gain makes Dell desktop the most desirable- performing large cap technology stock for the 2nd quarter.

Jan, again to you.

Thanks, Greg. HOPKINS: The Nasdaq simply comprehensive its worst half-year on listing. it is down 25 p.c for the 12 months thus far, and that i suppose traders don't deserve to live reminded that here's the third yr in a row that the Nasdaq is reduce.

For the S&P, this is the first half-yr in 30 years, a want of 14 %.

however, Lou, a new quarter begins on Monday.

DOBBS: some thing to stare ahead to, as i am confident basically every person is.

Jan, thanks.

smartly, accounting scandals, of path, are the seat of attention this week. company misbehavior at WorldCom, Xerox dealing yet another blow to investor self belief. buyers wondering just what on the planet is occurring and what's next.

With me now within the studio is Steve Forbes, the editor of "Forbes," impress Morrison, editor of "BusinessWeek," and joining us from la, invoice O'Neil. he's the leading man at "buyers enterprise every day."

And or not it's superior to bear you bar None here.

Let me begin, if i may, bill, with you. This market behaving, on the very least, badly within the visage of risky word on profits and scandals. What's occurring, to your judgment?

invoice O'NEIL, "traders enterprise day by day": well, I feel that or not it's the aftermath of the massive tulip bulb craze that went on in '98 and '99. In Holland, everyone purchased tulip bulbs and they went loopy over them, and it bar None blew up. and that's what took Place in excessive-tech and biotech.

DOBBS: i used to live considering extra, invoice, about this week. They discovered concerning the tulips a very long time in the past.

O'NEIL: sure. neatly, this week, the Nasdaq has been going down on account that January 1. it live had three waves down and this closing one is a diminutive steeper, and it undercut a low. however I believe you picked up some brief selling and there's been a all lot of news. so you're doubtless in along the lows.

The market has in fact shifted to customer shares. So i am no longer so positive that these fallen leaders in the high-tech sector are absolutely elementary for a market it is slowing to regularly pick up well over time.

DOBBS: Mark, your recommendations?

MARK MORRISON, MANAGING EDITOR, "BUSINESSWEEK": neatly, I suppose the market reacted pretty neatly on the grounds that the extent of the detestable information this week. The WorldCom and Xerox announcements had been rather stunning. Yet the market, after that news, acted relatively well, turned into relatively reliable.

and that i believe that in a selective means, the market did might live punish some of the businesses that -- the Place accounting questions are nevertheless lingering, those that use...

DOBBS: Amongst people that are...

MORRISON: EBITDA, the ones which bear pro forma accounting and bear pushed that idea. these -- the market reacted greater in a selective manner than in a ordinary, panicky option to the news.

DOBBS: Steve?

STEVE FORBES, EDITOR, "FORBES": I suppose it's generally right. I reflect the market is attaining a bottom. I suppose the more pessimism there is, the faster this issue goes to turn round. but one of the things I reflect it really is weighing on the market, it's not the spate of scandals about companies, but a passage that possibly we're not waging this struggle on terror as vigorously as they should still. I reflect if they went after Iraq and seized those oil fields, I consider you'll perceive the market actually stream up.

DOBBS: it's pleasing that you'd link those two. They did bear polls this week cautioned most effective 1/three of americans faith that we're really successful this war. What achieve you suppose of that concept, Mark?

MORRISON: I achieve not reflect it really is manner lots in the marketplace birthright now. I consider that the market is taking possibly some solace from the incontrovertible fact that the govt and corporate the usa seem to live taking severely this mess this is been going on in bookkeeping and in governance. And that some austere reform goes to approach back out of this on the different conclusion. That may additionally recall some time, six months or a year from now. although I believe...

DOBBS: can they bear time? I imply, it is the exciting query to me. invoice, let me examine you to are available on this. can they truly bear time? If we're drawn to restoring investor self belief, will they bear time to commemorate this play out and to peer what number of more are out there?

O'NEIL: I suppose the difficulty is, in the event you plug through a austere correction it's extended, you should achieve something to stimulate the economic system added. or not it's extra devotion 'seventy three, '74, even a bit bit like' 29. and that i suppose that live confident you accelerate up some of these tax cuts.

They may noiseless deploy a brand new act to give tax breaks to individuals who start a brand new business. That doesn't sordid for bar None traders, necessarily. but let americans who birth a brand new enterprise simplest need to pay half the common tax, and the owners and founders and employees that personal stock, might live after they promote the stock over the primary 10 years, to only pay half the capital features. this would birth a huge enlarge in new corporations.

(CROSSTALK)

DOBBS: i am sorry. Go forward, invoice.

O'NEIL: I consider you want some extra stimulus since you're going to approach out of this very slowly. you'll approach out of it, however you're now not going to approach roaring out devotion nothing ever took place.

DOBBS: Steve, your thoughts on this? greater centered investment tax credits, extra -- I can not reflect about you resisting that advice.

FORBES: No, my objection could live to the targeting. Why now not simply bear an throughout-the-board reduce on the capital gains tax? it truly is what they did within the mid Nineties and it worked. They mustn't overlook that the so-known as booming '90s, the primary half was the worst pecuniary recovery from recession due to the fact the '20s.

DOBBS: you're fully right. it live smooth to overlook that. so that you'd want to perceive it addressed via capital features. How in regards to the idea of a broader investment tax credit?

FORBES: smartly, I feel the key's for tax credit score, instead of attempting to play video games devotion they did in the early '60s with tax credit score on, tax credit score off. americans bear received to consider here is everlasting. And relocating up, as bill suggests, the anemic tax cuts they handed ultimate summer, which are fairly small, yield these effective now, that could back too.

DOBBS: well, investors and the audience of this broadcast, there's a real sense that they pick up here, that americans want to perceive actual outcomes. they're involved concerning the integrity of the markets. they may live concerned about transparency. They are looking to perceive impartial effects from company the us.

Mark, you bear been speaking about the EBITDA shares, the pro forma, in case you will, businesses and shares. impartial earnings -- is there going to live an enduring adjustment here, achieve you feel, to organizations that simply yield funds?

MORRISON: I feel there goes to be. and that's one explanation why I wager i'm a bit diminutive bit of a very superior information man about the WorldCom and Xerox news. I feel that this has helped thrust the administration and company the usa to correspond with that this become no longer only a case of a pair of detestable apples, but there truly is going to should live some austere apartment cleansing done.

And the option is, what? To configuration of skid through this episode. and then they Go again to trade as ordinary. And a yr from now, or two years from now, we've a worse issue.

DOBBS: We're going to revert again with bill O'Neill and impress Morrison and Steve Forbes, and dispute why the surprising urgency about company reform. And we'll approach to a conclusion -- or these three gents will approach to a conclusion no matter if this is the vice of the Democrats or the Republicans. reside with us.

(commercial damage)

DOBBS: We're back with Steve Forbes of "Forbes" magazine and impress Morrison of "enterprise Week" and bill O'Neil of "traders company daily."

gents, as I talked about at the destroy, they wish to find out whose vice here's, Republicans or Democrats. however first, the query that we're asking their viewers tonight is, has this market bottomed? And, bill, very instantly, has this market on your judgment bottomed?

O'NEIL: I feel it doubtless has. but when it does not, I feel the government must step up and lower some taxes and achieve a few issues, as a result of there is too lots horror and it live been going on too lengthy. And they don't should bear it. it's down in along what must live the backside. And there changed into best the Nasdaq this is been exerting the actual power.

DOBBS: Mark?

MORRISON: I don't perceive a bottom yet. I believe here's a undergo market and they will bear to wait and spot. We're bumping along at low component but valuations are nonetheless excessive. I don't perceive a impartial turn yet.

DOBBS: And, Steve, simply moments ago you used an expression, "looking for a backside." How goes the search?

FORBES: I feel if we're no longer at it, we're very nigh it. I consider traders who devotion to play timing video games should start to live going again in. I believe we're going to bear a rally pretty soon. The extra pessimism there is, the more advantageous the market's going to do.

DOBBS: One would hope that they would now not perceive a stronger wall of fret confront us than this, or better pessimism. Who can they vice here? Mark, Republicans or Democrats?

MORRISON: actually politicians are partially in charge. They bear been on the trip with the traders and with the accountants and with the executives. And bar None and sundry, even the media, bear been on the huge journey in the late '90s, when bar None these excesses and shortcuts begun.

So, as far as Washington goes, I don't pin the vice on either party. I consider that, absolutely, the Bush folks are having to exchange their tune very dramatically as a result of their view of letting the markets achieve bar None the law is not working.

DOBBS: looks devotion there may live an hobby in some influence other than a market result, in the case of Enron, for example. invoice?

O'NEIL: smartly, the market topped in March of 2000. so you can vice it on either birthday party you are looking to. however human nature is human nature. and every unique endure market I've ever seen, every unique recession, has a few organizations Go bankrupt, a few individuals which are doing some thing dishonest pick up caught.

And the SEC does a superior looking respectable job. at some point they'll seize each one of these individuals. So I achieve not reflect that you would live able to vice it on one birthday celebration or the other.

DOBBS: adequate, Steve? FORBES: well, I reflect if you need to stare on the tone of the '90s, it started birthright at the appropriate, on the White condominium, where the perspective changed into anything goes. if you pick up caught, spin your means out of it. The handiest component they failed to visage up to -- they could withstand everything except temptation. So it bar None started at the true.

DOBBS: and how about Wall road, the investment bankers, the analysts, bar None of the trade banks assisting these deals?

FORBES: There became an attitude that there are not any greater rules, that you might thrust the envelope, pick up to the facet, topple off the facet. The parachute would protect you. And effects was what counted. brief- term results is what counted. And we're having the hangover.

MORRISON: They even bear to stare at where the cash turned into coming from, from a very refined group of institutional traders who rush money for states and pension funds and the rest, who bear been simply very chuffed to yield investments in the Enrons of the world after they couldn't even live mindful the company or the reports.

(CROSSTALK)

DOBBS: bill, you pick up the remaining live sensible on this thing. achieve you devotion the thought of bar None these refined cash managers now suing to suitable the market's correction, in case you will?

O'NEIL: smartly, I feel the largest issue, it's unhappy for the general public. Most traders achieve not really recognize a passage to withhold money into a sound means. They achieve not truly recognize a passage to protect themselves in poorer periods. and that i'm hoping that they'll recognise this and commence trying to anatomize and live trained more about the passage to elect shares, how to sell them, the passage to tackle them, in preference to simply accepting what anyone else says.

DOBBS: That became possibly an confiscate approach after they could watch 25 p.c beneficial properties. or not it's a diminutive distinctive world, as you imply, invoice. invoice O'Neil, thanks for being with us. impress Morrison, Steve Forbes, recognize it.

coming up subsequent, difficult questions ahead for the us in the conflict towards terrorists and radical Islamists. they will bear the MONEYLINE "Economist" journal special document for you subsequent, in "the united states: New directions." dwell with us.

(commercial spoil)

DOBBS: The continuing MONEYLINE "Economist" magazine collection on "American management: New instructions." Tonight they recall a glance at the problem ahead for the U.S. in sustaining this conflict in opposition t terrorism and radical Islamism. we're inspecting even if the usa has the will to head it on my own if integral -- politically, economically and militarily.

(start VIDEOTAPE)

GEORGE W. BUSH, PRESIDENT OF the united states: nowadays, their fellow citizens, their tradition, their very freedom came below assault. DOBBS (voice-over): The president's battle on terrorism has set the stage for a new American period. however's too created challenges to the USA on two fronts: to their political and military power, and to their economic energy.

The president's coalition has been strained and tenuous from the beginning. India, Pakistan, each distinguished participants of that coalition, and both nuclear powers, went to the brink of conflict. France, always uniquely independent in coalition, appears more aligned from time to time with Iraq.

other European international locations, together with their closest ally, Britain, at highest trait seem to live uneasy about U.S. coverage in the seat East.

JAMES A. BAKER III, FMR. SECRETARY OF STATE: I reflect as they movement forward within the battle on terrorism, which is going to live a protracted and strenuous combat, they will endure coalition fatigue. We're suffering it because of the Arab/Israeli conflict, we're struggling it as a result of the concerns between India and Pakistan.

invoice EMMOTT, EDITOR IN CHIEF, "THE ECONOMIST": I consider Colin Powell has it correct. He says that the crucial component is to maintain talking, to relate your allies what you might live doing, why you are doing it. however now not always give them a veto about what you're doing.

BAKER: The most effective and greatest check of a mighty vigour is the skill to achieve whatever unilaterally when your country wide hobby requires it.

DOBBS: American leadership during this new era may require the USA to Go it lonesome in accordance with the threats posed with the aid of both Saddam Hussein and Osama bin laden.

EMMOTT: I consider that to yield feel of Osama bin weighted down's terrorism, you should anticipate what he'd truly care to achieve is to emulate Lenin. Lenin was a terrorist who became potent because he got Russia and took over Russia. Osama bin laden is simply a terrorist presently. He can handiest pick up effective via getting Saudi Arabia or Pakistan or another country.

DOBBS: Kenneth Pollack is a former CIA defense obligate analyst. Pollack says the time for half-measures in opposition t Saddam Hussein is handed.

KENNETH POLLACK, COUNCIL ON international family members: I feel a full- scale invasion is going to live huge. it's going to live expensive. lots of people are going to lose their lives in it. That referred to, I achieve not reflect that it might live practically as expensive as fighting a warfare against Saddam Hussein once he has got nuclear weapons.

DOBBS: the area's simplest superpower, which is additionally the realm's wealthiest nation, will devoid of query live stressed by passage of the rising fees of a world battle with elusive enemies. The charge of combating the battle this 12 months will confiscate $seventy six billion.

nonetheless, if the Bush administration wins congressional approval of its total protection funds raise, that finances will nonetheless live near historic lows -- below half what it changed into bar None over the bloodless conflict, as a percent of the U.S. low home product.

BAKER: the region has asked lots of U.S. pecuniary engine for a long time. Over the course of the past 10 years we've got been the best impartial supply of international boom.

UNIDENTIFIED MALE: Their heroes will now open the market.

DOBBS: america's pecuniary power is the basis and engine integral to pressure this war. that is why trade scandals devotion Enron and WorldCom threaten more than simply self faith in the markets and the economic system.

EMMOTT: After the bursting of the inventory market bubble and bar None of the abuses at Enron and global Crossing and Tyco, and bar None of these, I suppose america's going to bear a bumpy pair of years. birthright through that period, the usa's confidence in its skill to proceed to fund protection spending and need to Go out in the world could pick up dented every now and then.

DOBBS: The pecuniary costs and political dangers of this battle will live super. however the deserve to win the warfare is essential. And so is the possibility to obtain global peace and prosperity, in keeping with natural American values of democracy and free markets.

EMMOTT: the usa has the possibility to reshape the world in quite a lot of nice techniques in the following pair of years. The query is whether or not it'll continue to bear the incentive to achieve it and leave from the relaxation of the area. My faith is that it'll bear each.

(end VIDEOTAPE)

DOBBS: the brand new edition of "The Economist" journal is committed to the altering position of yankee leadership due to the fact that September eleventh. known as "the usa's region on earth," it's on newsstands now.

And coming up next here, the results of their MONEYLINE poll on whether you suppose this market has ultimately hit bottom.

And, how the give passage of Enron has given three women the probability to capitalize from company failure. linger with us.

(industrial damage)

DOBBS: And this just in to CNN. The Walt Disney company, based on Reuters, will restate its 2000 and 2001 revenue. That in line with SEC filings. The Reuters once more reporting that Disney will restate its salary. And the explanation for that restatement, in line with those SEC filings, is a math error.

Turning now to a different setting up story, explosions heard tonight in the West bank town of Hebron. Palestinian security sources command seventy five p.c of the Palestinian complicated became destroyed. Israeli troops had been outside the complicated for a pair of days now making an attempt to negotiate the give up of Palestinians.

in the meantime, President Bush's seat East map has met with some skepticism on the G-8 summit this week. As you comprehend, G-8 leaders agreeing with the convene for Palestinian statehood. however some aphorism it's as much as the Palestinians to elect their leaders. joining me now to dispute this new initiative is the former Secretary of status Henry Kissinger.

Henry, first rate to bear you with us birthright here.

HENRY KISSINGER, FMR. SECRETARY OF STATE: always superior to live with you.

DOBBS: i know you were in Europe when the president withhold forward the initiative. First, what's your response? Is it a judgement behind hope?

KISSINGER: smartly, the president made limpid that there is never one map you could withhold forward for a negotiation until you bear got companions for you to bear some self assurance in. and i consider that was an distinguished contribution.

And in the next phase, once some progress is made in that route, I reflect within the next section, there could live progress in negotiations. and i reflect what must occur next is that the qualify Arab countries assume some accountability for the domestic adjustments that the president spelled out for the Palestinians.

since the Palestinians aren't able to achieve it via themselves below current situations. And that means, there could live created a negotiating partner.

DOBBS: Is it your sense that Saudi Arabia, in selected, Egypt, Jordan, bear both the skill and the will at the flash to live a positive bear an effect on on any reform that the Palestinian Authority must bear to yield it feasible for statehood, even on an meantime foundation?

KISSINGER: neatly, they've the potential. and i feel they're constructing the will to achieve that. likely they'll insist that there's some growth in negotiation -- or some negotiations being conducted. earlier than the complete manner of internal trade in the Palestinian areas is completed. however I believe that they are becoming very stressed with the bear an impact on on them of the continuation of suicide bombing and turmoil.

DOBBS: And for the Israelis, the president's insistence that the settlements, the construction of settlements, desist on the West bank and in Gaza, that there live effectively a roll-lower back to the pre-'67 warfare borders. Is that an affordable, and achieve you reflect possibly productive, initiative?

KISSINGER: I suppose possibly, sure, I consider it is. I feel the president has called consideration to the incontrovertible fact that you cannot Go from birthright here to a closing contract. You should commence through restoring circumstances by which gardenvariety existence can birth once again.

And here is why he's entreated the Israelis to Go back when the Palestinians bear made their adjustments, to the situations that existed when this complete disaster bar None started. And additionally to conclusion any new condense undertaking. I suppose here's an inexpensive foundation on which to commence negotiations.

DOBBS: Dr. Henry Kissinger, thank you very a all lot for being with us, as at bar None times.

KISSINGER: enjoyment to live on.

DOBBS: Let's recall a quick stare now at the effects of their MONEYLINE ballot. Tonight's query: achieve you believe that this inventory market has ultimately hit bottom? Twenty % of you said yes, 80 percent said no. And, while now not scientific, a impartial indication. and that i must command that the market doesn't issue to live arguing with the effects of this poll.

arising next, the "Dobbs document." a pair of innovations about the rising political temperature and posturing in Washington about corporate scandals. linger with us.

(business break)

DOBBS: well, after the scandals at Enron, three enterprising former Enron ladies bear decided to recall advantage of their mishap through making an attempt to enrich their fortunes, performing in "Playboy" magazine. and that they're cashing in significantly neatly in a whirlwind media tour which has led them, of course, to new york metropolis. and they are, in case you live interested, appearing in the August situation of "Playboy" magazine.

neatly, Enron, international Crossing, Tyco, ceremony help, Qwest, Adelphia, ImClone methods, now WorldCom -- the Democrats bear establish a crusade subject, company abuse. The Senate majority leader says the challenge will play in each status this November. Tom Daschle nowadays charged that the Republicans -- quote -- "dismantled the regulatory atmosphere they had and, in significant measure, created the sense of laissez faire," conclusion quote.

Even Al Gore wants to play, asserting at a fund raiser here in long island this week that the president's tax guidelines resemble the outbreak of accounting fraud.

I achieve not need to live a spoilsport here, however did both Mr. Gore or Senator Daschle note that these multibillion greenback company restatements Go back to 1997? That the telecommunications act turned into 1996?

And now, of route, President Bush needs to Place them in penal knotty and the treasury secretary wants to hang them excessive. George Bush and Paul O'Neill talking about company criminals, now not the Democrats. The president is siccing the Justice fork on the risky guys and the SEC is investigating just about every most distinguished enterprise within the nation.

once again, I achieve not want to live a spoilsport birthright here, however does the Bush administration neglect that it's been supporting Senator Phil Gramm's efforts to cease accounting and corporate reform on Capitol Hill for months now?

Do the Republicans and the Democrats both understand that the American investing and balloting public is sensible that or not it's been six months since Enron went bankrupt, and None of those condo or Senate investigations -- of which there had been a dozen -- bear amounted to the ease to this element? That there were no fees introduced towards a unique Enron executive?

If the Republicans and the Democrats are thinking about reform now, ultimately, then their movements will bear to live as a minimum as energetic as their thrust rhetoric.

this is MONEYLINE for this Friday night. Thanks for being with us and bear a extremely pleasing weekend. For everyone here, respectable nighttime from imposing apple.

TO ORDER A VIDEO OF THIS TRANSCRIPT, tickle title 800-CNN-information OR use THEIR relaxed online ORDER benevolent establish AT www.fdch.com

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Puma Biotechnology, Inc. (PBYI) CEO Alan Auerbach on Q2 2018 Results - Earnings convene Transcript | killexams.com real questions and Pass4sure dumps

No result found, try new keyword!As investors are aware, they bear an ongoing phase III visitation of neratinib in third-line HER2-positive ... from physicians and too as you know there is a lot of these online videos that physicians post ...

ASCO GU 2019: Results of a 50 Patient Single-Centre phase II Prospective visitation of Lutetium-177 PSMA-617 Theranostics in mCRPC | killexams.com real questions and Pass4sure dumps

San Francisco, CA (UroToday.com) PSMA is over-expressed in bar None prostate tissue, including prostatic carcinoma. Lutetium-177 (177Lu)-PSMA617 (LuPSMA) is a small radiolabeled molecule which binds to PSMA and delivers a dose of β radiation. Lutetium-177 is a superior partner to assist deliver the radiation because of the short orbit β radiation (maximal tissue penetration of <2mm), thereby decreasing the potential collateral damage to nearby organs. 

The authors of this study bear previously reported on their suffer of 30 men with metastatic CRPC treated in a single-center phase II prospective visitation of LuPSMA.1 This abstract represents an updated analysis of an extended cohort of 50 patients.  

In this phase II trial, 50 men with PSMA-avid (defined as elevated PSMA expression in at least one site of metastatic disease with > 1.5 SUV of the liver) mCRPC who had progressed after gauge therapies (including docetaxel and androgen-axis targeted therapies) received up to 4 cycles of LuPSMA every 6 weeks. The plenary protocol can live seen below: ResultsSchema_177LuPSMA.png

The primary endpoints were PSA response (according to PCWG2 criteria) and toxicity (according to CTCAE v4). Secondary endpoints included imaging response, PSA PFS and OS. 

75 men were screened to identify 50 patients eligible for treatment. Median PSA doubling time was 2.6 months. The majority of patients had received prior docetaxel (84%), cabazitaxel (48%), and abiraterone and/or enzalutamide (90%). plenary demographic info is seen below:PatientDemographicInfo.png

These men are heavily pretreated mCRPC patients with limited alternative options. The mean administered radioactivity was 7.5 GBq/cycle.  

In terms of response, PSA decline ≥ 50% was achieved in 32 of 50 patients (64%, 95% CI 50-77%), including 22 patients (44%, 95% CI 30-59%) with a PSA decline ≥ 80%. Best PSA response is depicted here: BestPSAResponse_ASCOGU.png

27 patients had measurable soft tissue at baseline and 56% of these patients had a partial or complete response by RECIST 1.1 criteria.  

Median PSA PFS was 6.9 months (95% CI 6.0-8.7) and median OS was 13.3 months (95% CI 10.5-18.0). Upon subsequent progression, further LuPSMA was administered to 14 patients (median 2 cycles commencing 359 days from enrolment); PSA ≥ 50% response occurred in 9 patients (64%), indicating the option for retreatment. 

The PFS KM curve:PFS_KM_Curve.pngPatients who had a >= 50% response had a PFS of 8.3 months. 

OS K-M curve seen below:OS_KM_Curve.pngMen who had a >= 50% PSA response had a median OS of 18 months.  

Overall, LuPSMA was well tolerated. The most common toxicities attributed to LuPSMA were transitory G1-2 dry mouth in 68%, G1-2 nausea in 48%, and G1-2 fatigue in 36%. G3-4 toxicities attributed to LuPSMA were infrequent with thrombocytopenia in 10% and anemia in 10%.  

Using this expanded 50 patient cohort confirms elevated response rates and low toxicity with LuPSMA in men who had progressed after gauge therapies. In patients who subsequently progressed and were administered further LuPSMA, elevated response rates were too observed, indicating that this treatment can live repeated with significant response. These results bear provided the basis for randomized controlled trials currently underway – the ANZUP/PCFA TheraP trial (Lutetium-PSMA vs. cabazitaxel) and the Endocyte VISION trial.  

Presented By: Michael Hofman, FRACP, MBBS, nuclear medicine physician in the Centre for Cancer Imaging at the Peter MacCallum Cancer in Melbourne

Written by: Thenappan Chandrasekar, MD, Clinical Instructor, Thomas Jefferson University; Twitter: @tchandra_uromd, @JEFFUrology at the 2019 American Society of Clinical Oncology Genitourinary Cancers Symposium, (ASCO GU) #GU19, February 14-16, 2019 - San Francisco, CA

References: 

  • Hofman MS, Violet J, Hicks RJ, Ferdinandus J, Thang SP, Akhurst T, Iravani A, Kong G, Ravi Kumar A, Murphy DG, Eu P, Jackson P, Scalzo M, Williams SG, Sandhu S. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study. Lancet Oncol. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Epub 2018 May 8. 

  • Fujifilm X-A5 Unveiled as Smallest & Lightest X string Mirrorless Digital Camera | killexams.com real questions and Pass4sure dumps

    FUJIFILM unveiled today the Fujifilm X-A5 as the smallest and lightest X string zoom lens kit mirrorless digital camera featuring recently developed sensor and color reproduction technology.

    Sporting a 24.2MP APS-C sensor with 1.5x crop factor that features a phase detection autofocus system and Fujifilm's latest image processing engine capable of offering processing speeds of up to 1.5 times faster than previous models, Fujifilm X-A5 offers higher ISO sensitivity of ISO12800, more accurate scene recognition in SR+ AUTO mode, 4K movie recording, a 180 degree tilting rear LCD with feel screen, and Bluetooth support.

    "Combined with Fujifilm's renowned outstanding image trait with the company's proprietary color reproduction technology, the X-A5 is compact, stylish and portable making it the model companion for everyday photography," says Fujifilm in today's announcement. "The X-A5 combines a newly developed 24.2 megapixel APS-C sensor with the image processing engine to achieve Fujifilm's renowned photo quality."

    The first X-A string model to feature phase detection pixels

    Fujifilm X-A5 is too Fujifilm's first X-A string digital camera to feature phase detection pixels, which can live establish only in the high-end X string models. Also, Fujifilm X-A5 includes the first electric-powered zoom lens for the X Mount, the FUJINON XC 15-45mm (23-68mm in 35mm format) f/3.5-5.6 OIS PZ, which Fujifilm says it's consummate for photographing human subjects, but too for capturing those "can't-be-missed" moments on your holidays.

    Also noteworthy is that Fujifilm X-A5 integrates an smart Hybrid AF that's twice as snappy as in previous models so you won't miss any crucial photographic moment, as well 11 variations of Fujifilm's unique Film Simulation Modes, including the new "HDR Art" and "Fog Remove." final but not least, Fujifilm X-A5 incorporate the latest Bluetooth Low Energy technology for smooth pairing with Fujifilm's Camera Remote app for iOS and Android.

    Fujifilm X-A5 is too compatible with the FUJIFILM Instax participate SP-3 printer and offers a High-Speed HD Video office and new 4K video capabilities. A new battery was included as well in this model, promising to allow you to shoot up to 450 photos per unique battery charge. Fujifilm X-A5 weighs only 496g, which makes it the consummate camera for travel photographers. Fujifilm X-A5 costs $600 USD and it's available in Brown, Silver, and Pink colors.

    Fujifilm X-A5

    Fujifilm X-A5

    Fujifilm X-A5

    Fujifilm X-A5



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