500-205 exam Dumps Source : SP Optical Technology Systems Engineer Representative
Test Code : 500-205
Test cognomen : SP Optical Technology Systems Engineer Representative
Vendor cognomen : Cisco
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Cisco remains on the innovative, using optical industry innovation for their consumers. these days, I’m restful to declar that we've carried out the rating of Optical network Market leader in the 2018 IHS Markit technology supplier Scorecard.
mainly, the record states that Cisco leads the box this yr in market partake momentum with NCS a thousand earnings to the net-scale neighborhood, mixed with the start of the Verizon 100G metro-packet optical project.
The only file of its variety, this Scorecard evaluates the desirable optical community materiel carriers on standards the usage of concrete records and metrics, together with direct comments from patrons, dealer market share, market partake momentum, financials, manufacturer recognition, popularity for innovation, and other benchmarks. This strategy eliminates subjectivity and ensures companies are assessed accurately and relatively.
day after day they set out to lucid up their shoppers’ excellent challenges. i would dote to thank their clients and partners for your endured partnership – you assist gas their coerce to proceed business disruption and innovation. I furthermore lengthen congratulations to the Cisco Optical techniques group and admire their complicated travail in incomes this tall difference.
study more about Cisco’s newest improvements on their Optical Networking website.
(Corrects income pattern to $12.45 billion and estimates to $12.41 billion in paragraph three)
Feb 13 (Reuters) - Cisco methods Inc reported second-quarter income that beat Wall highway estimates on Wednesday, because the community apparatus maker benefited from its shift to newer companies comparable to software application and cyber security.
The business mentioned web revenue of $2.eight billion, or 63 cents per share, in its quarter ended Jan. 26, in comparison with a loss of $eight.seventy eight billion, or $1.78 per share, a 12 months prior, when it took a permeate of $eleven.1 billion concerning the novel U.S. tax legal guidelines.
total salary rose four.7 % to $12.45 billion. Analysts on typical had expected income of $12.41 billion, in keeping with IBES statistics from Refinitiv. (Reporting by Arjun Panchadar in Bengaluru; enhancing via Anil D’Silva)
in keeping with Bloomberg, Cisco methods CSCO is in talks to purchase Luxtera Inc., an optical chip technology enterprise, for an undisclosed quantity.
Per sources customary with the count, the deal may well exist worth lots of of thousands and thousands of greenbacks. based on reviews, Cisco became the winner, beating the friends Intel Corp. INTC and Broadcom Inc. AVGO, in the bid to purchase Luxtera.
besides the fact that children, details are scarce at this constituent because neither party turned into obtainable for comment. chiefly, it’s even feasible that the buyout agreement may not even materialize.
Headquartered in Carlsbad, CA, Luxtera’s silicon photonics know-how offers extreme velocity of information transfer across video streaming, cloud and mobile. The deal will assist Cisco add extra primary technology to its open-supply application with the objective to construct networking equipment.
Coming to the expense performance, shares of Cisco Have again 23.4% in a 12 months, outperforming the business’s rally of 20.5%.
Synergies from Buyout
the mixing of Luxtera’s silicon photonics expertise with Cisco’s community and cloud security platforms is probably going to further boost protection facets and assist the latter consequence extra differentiated items, thereby mitigating phishing incidents on devices. This acquisition will assist Cisco to convey on its commitment of safeguarding customer data while focusing on americans-centric cozy commercial enterprise IT approach.
With this buyout, Cisco’s consumers should exist in a position to adventure more desirable flexibility in operations, superior multi-stage protection, multiplied awareness and more desirable administrative control.
Cloud know-how is being increasingly adopted throughout agencies to innovate, deal with greater volumes of sensitive records, tender protection to towards cyber-safety threats and power boom. This merger will assist each the businesses leverage each and every different’s materials to create an creative enterprise model and consequence the environment more relaxed.
over the final few years, strategic acquisitions Have played a crucial position in shaping Cisco’s extend trajectory. The enterprise closed the acquisition of chaperone for $270 million and privately-held Duo security for $2.35 billion in cash.
Cisco additionally announced its plans to purchase Burlingame, CA-primarily based July systems. Cisco is neatly poised to leverage the modern know-how at a lot of stages of its operations and gain a aggressive side.
continuous strategic acquisitions should noiseless steer Cisco in expanding its product offerings, strengthening footprint within the security markets and building client base. further, these acquisitions pomp the company’s objective to raise its application and service capabilities as a artery to diversify salary streams to consequence it extra habitual in nature. it's taking this initiative to mitigate the cyclicality linked to hardware revenue.
youngsters, these acquisitions are more likely to retain Cisco’s operating margins under pressure, because it requires giant volume of novel investments.
Zacks Rank and shares to accept as upright with
presently, Cisco contains a Zacks Rank #3 (hang).
a better-ranked stock in the broader know-how sector is Twitter, Inc. TWTR, wearing a Zacks Rank #1 (powerful purchase). that you may survey the comprehensive record of nowadays’s Zacks #1 Rank stocks prerogative here.
Twitter has long-term expected profits growth fee of 22.1%.
looking for shares with Skyrocketing Upside?
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Freeze drying is a long and expensive fill/finish operation that is required for many pharmaceutical and biotechnology products to ensure product stability, efficacy and long shelf life prior to distribution to patients.
One of the key parameters affecting product attribute is residual moisture (RM) content. The RM is typically lowered to a flush that will no longer uphold chemical reactions (or biological growth).
RM is lowered to control chemical and physical degradation processes. Although most drug products are dried to RM values of <1%, some of the novel biotechnology products may require an intermediate RM value, 2-5%, to maximize product stability, safety and efficacy.
Despite the weight of RM, there is currently no real-time monitor capable of determining RM throughout the secondary drying aspect of lyophilization.What consequence would too much, or too shrimp water Have on a finished pharmaceutical product?
The consequence of residual moisture on product stability has been studied for numerous products. In most cases lower levels of residual water improves stability and the manufacturer needs to balance increased drying times that result in lower water levels with a reduction in process efficiency and additional processing complications to achieve and maintain the extremely low levels of residual moisture.
In some cases, lower levels of residual water can lead to a reduction in product stability, specifically for protein-based products and vaccines. It has been reported that a minimum flush of residual water is required for conformational stability and over-drying can lead to a loss in product attribute and stability.What does Physical Sciences Inc. tender to monitor and manage water removal?
Physical Sciences Inc. has developed a Tunable Diode Laser Absorption Spectroscopy (TDLAS) based water vapor mass rush rate monitor, called the LyoFlux®, that provides continuous measurements of the water removal rate during pharmaceutical freeze-drying operations.
The sensor uses a non-intrusive, near IR optical absorption technique to monitor the water vapor concentration and gas rush velocity in the duct connecting the lyophilizer product chamber and condenser.
These measurements are used in combination with the duct cross-sectional locality to calculate the instantaneous water vapor mass rush rate (grams/second) in the duct. These measurements can exist integrated to provide a continuous, real-time determination of the total amount of water removed during the freeze-drying process.
We note that the determination of product RM is a shrimp harder to determine. The quit user cannot simply subtract the integrated TDLAS measurements of water removed during freeze-drying from the total amount of water added to the batch of vials undergoing freeze-drying.
This is because the total solid content of the formulations is typically in the 5% - 10% range. Measuring RM of the remaining solid following drying would require a measurement oversight of 0.05% - 0.1% for a product RM content of 1%.
This is beyond the capability of the TDLAS sensor, and in fact most analytical instruments. In collaboration with the University of Connecticut, TDLAS-based determination of RM has been demonstrated based on correlating the TDLAS measured water vapor concentration at the quit of primary drying to Karl Fisher based RM measurements.
The progress of the correlation curve for a specific product is performed once in a laboratory scale freeze-dryer and then has been used for subsequent laboratory and pilot scale experiments. This correlation curve essentially erases the measurement oversight accumulated during primary drying and enables accurate integration of the measurements during secondary drying to predict product RM throughout secondary drying with a useful measurement accuracy of +/-0.5%.What features does PSI tender to ensure a amenable freeze-drying process?
The LyoFlux® sensor provides real-time data that can exist used to efficiently develop and monitor freeze drying processes. exhaust of the sensor helps process engineers redeem time and money in developing their cycles and supports rapid character of product by production engineers following a process disruption.
PSI, through a long and productive collaboration with the University of Connecticut, has demonstrated numerous applications of the LyoFlux® technology for monitoring freeze-drying processes including the determination of:
Many of the pharmaceutical industry quit users Have furthermore demonstrated these measurements and additional applications of the technology, including the progress of attribute by Design (QbD) lore and design spaces.
Back in the late 1990’s and early 2000’s a couple of essential papers were published that demonstrated that through the exhaust of gravimetric determinations of mass rush and the well-accepted constant condition model of heat and mass transfer of vial-based freeze-drying, a product, vial and dryer specific process design space could exist calculated and graphically displayed that provided lyophilization process engineers with a comprehensive overview of the drying process.
This approach calculated shelf and product temperature isotherms of the water vapor mass rush rate as a role of process pressure. When combined with the lore of the materiel capability limit, furthermore displayed as mass rush as a role of process pressure, the graphical output provided a QbD based manner of developing the lyophilization process design. In addition, the process engineer could predict how the product temperature would respond to feasible process shocks in pressure and shelf temperature.
The only problem with the gravimetric based approach was that the data required to calculate the lore and design spaces would require weeks to months to obtain. That is because gravimetric based experiments required for the data collection had to exist dash in constant state.
These data were used to determine the key parameters including the pressure contingent values of Kv, the continuously changing value of Rp (as a role of parch layer thickness) and the pressure contingent materiel capability limits.
Use of the TDLAS sensor to acquire the very data means that experiments no longer had to exist dash at a fixed set of conditions (e.g. pressure) and this shortened the data collection age to approximately 1-2 weeks. The exhaust of the TDLAS sensor to develop the process design space will Have the highest repercussion on pharmaceutical freeze-drying process development.The LyoFlux sensor from PSI are furthermore available to exist fitted into SP Scientific freeze-dryers, delight give an overview of your partnership and how this collaboration helps both companies stay at the cutting edge of freeze-drying.
PSI has had a relationship with SP Scientific from the initial experiments that demonstrated the feasibility of the TDLAS measurements in a Lyostar 2 freeze dryer back in 2004. During the past ~5-years, this relationship has been strengthened and is now producing product improvements and novel products that directly capitalize their pharmaceutical customers.
This collaboration has enabled efficient application of the TDLAS technology to different scale lyophilizers, such as the miniature LyoCapsule and the larger LyoConstellation S20 pilot scale dryer.
We Have successfully demonstrated accurate mass rush measurements and importantly, accurate determinations of batch average product temperatures when the mass rush measurements were combined with the heat and mass transfer model of freeze drying. Thus, these tools enable more rapid process progress and scale-up, ultimately allowing quit users to streamline their processes and Get their products to the market faster.
A key improvement has been the progress of software that allows direct communication between the freeze-dryer and the TDLAS sensor. This communication provides the sensor with continuous measurements of the freeze dryer product chamber pressure, shelf temperature and the product temperature data.
The pressure and shelf temperature values provided to the sensor remove the need for user inputs to the sensor throughout the lyophilization process and allow truly autonomous operation of the sensor 24/7/365. This is a tall capitalize to the quit user, saving time, resulting in fewer data collection errors and providing a single location for capturing and plotting the process data for subsequent analysis.
Process recipes are input into the dryer and the user initiates the freeze-drying cycle, from this point the process runs without operator intervention to apply this technology. At the arrogate times in the process the dryer opens and closes the isolation valve to determine measurement offset values and initiates sensor integration of the mass rush measurements.
The TDLAS sensor measurements and full of the resulting heat and mass transfer model data products calculated using the sensor and freeze dryer data are transferred to the lyophilizer control computer for storage using the dryer data historian. This ensures a common time stamp for full of the data and easier pomp and processing by the quit user.
The collaboration between SP Scientific and PSI keeps us both at the cutting edge of freeze-drying technology by allowing us to travail together on research and progress projects. The establishment of communication (and control) between the sensor and the freeze-dryer has furthermore provided the foundation for more advanced applications of the sensor technology. PSI and SP Scientific recently completed a collaborative R&D pains that has created the TDLAS SMART Freeze Dryer technology.
The TDLAS SMART FD enables the progress of a freeze-drying cycle using a single experiment. It combines the existing Manometric Temperature Measurement (MTM) based SMART algorithm with TDLAS determinations of the water vapor mass rush to create a novel product that overcomes the limitations of the original MTM based product.
The SMART™ freeze drying technology automatically generates a freeze-drying cycle based on user inputs of product characteristics and vial dimensions, combined with non-intrusive TDLAS-based in-process product temperature measurements and a pseudo-steady condition heat and mass transfer model of freeze drying in vials.
This progress enables the application of the SMART FD technology for a much wider orbit of product formulations, including towering weight percentage amorphous biological products, on both laboratory and pilot scale freeze dryers, supporting both process progress and scale-up.
PSI and SP Scientific continue to explore additional applications and automation of cycle progress with the ultimate goal of sensor-based cycle control. They recognize that automated cycle control will require many years of additional R&D and industry testing, but achievement of this goal is directly in-line with the FDA Process Analytical Technology (PAT) and attribute by Design (QbD) initiatives.What features uphold your customers in increasing their understanding and robustness of the routine freeze-drying process?
The recent progress and rollout of sensor and freeze dryer software packages enable direct communication and control between the sensor and the lyophilizer are essential improvements for their customers. The communication (and control) capability significantly improves user application of the sensor technology, reducing the potential for end-user errors in applying the LyoFlux® sensor.
The data sharing between the two systems furthermore enables real-time and accurate calculation of the heat and mass transfer model data products and storage of the data on the freeze-dryer. Their goal is to eventually purge the sensor user interface, preparing the combined system for application in a manufacturing environment.
This will provide quit users with a moneyed library of data for each batch of the product that is freeze-dried. Currently these true time data sets provide process progress scientists with the information needed to extend their understanding of the drying process, life cycle management, and enable progress of robust processes using attribute by Design principles. In the future this data will exist available to enable more rapid release of lyophilized product and more rapid character of product following process deviations.How does the TDLAS sensor integrate with other freeze dryer scales in the manufacturing process to ensure a smart approach to production and a amenable attribute of the product?
The LyoFlux® sensor is applicable to full size freeze dryers as long as they can insert an optical spool in between the freeze dryer product chamber and the condenser. PSI has demonstrated application on dryers ranging from the SP Scientific LyoCapsule® miniature, seven, 20mL vial lyophilizer, which has a 2-inch spool, up to a manufacturing scale lyophilizer which has a 30-inch diameter spool.
The sensor control electronics, data acquisition and processing algorithm are common for full size dryers. A fiber optic and electronic signal umbilical cable connects the sensor control unit to the freeze dryer optical spool.
A common optical platform is used for full spools, thus the only change with dryer scale is the size of the spool and the location of the optical ports. Because they are using absorption spectroscopy, longer absorption pathlengths associated with larger spools provide higher signal to hullabaloo ratios.
To date their most common installation has been on the SP Scientific Lyostar 3 laboratory scale freeze-dryer, but they Have fielded many recent inquiries for potential installations on larger dryers.
We believe that this indicates a natural evolution of the product application from the laboratory to manufacturing scale. It may exist occurring at this time due to widespread industrial lore of the technology and the numerous publications describing application of the sensor, including a publication by the FDA.
Companies that adopt the LyoFlux® technology for monitoring their processes on full scale freeze dryers will Have common data sets from progress through scale-up to manufacturing. This should result in improved process understanding, likely faster time to market and more efficient assessment of product attribute in the event of process disruptions.What’s next for Physical Sciences Inc?
Physical Sciences Inc. continues to travail with both their academic and industrial collaborators to develop next generation sensors, and to improve application of the TDLAS technology, with the eventual goal of using the LyoFlux® sensor and other PAT sensors for real-time process control.
PSI is currently collaborating with university and industrial partners to apply the TDLAS technology and process models for improved lyophilization process progress and scale-up. This includes the progress of a novel aseptic, pilot scale lyophilization facility to enable testing of novel sensors and process progress models in an environment that is representative of a manufacturing facility.
This will uphold the pharmaceutical industry and the training of the next generation scientists and process engineers on lyophilization process progress and scale-up. This facility, which is expected to approach on-line in tumble 2019, will exist available as a user facility to both academia and industry. In summary, they are noiseless actively pursuing numerous R&D projects to further the sensor and its application.Where can users find more information? About Bill Kessler
Bill Kessler received his undergraduate and graduate degrees in chemistry from Boston University, performing ultra-high-resolution gas spectroscopy. His research focused upon multi-photon excitation of aligned ionic states.
In 1986 Bill joined Physical Sciences Inc. in Andover, Massachusetts as a staff scientist. His travail at PSI has spanned numerous disciplines including combustion, atmospheric, and chemical laser research. Bill’s focus shifted to the progress of diode laser-based sensors and sensor networks which leveraged the tools created by the optical telecommunication industry for industrial sensor applications.
In December 2000 Bill became a founding member of the PSI-spinout company, Confluent Photonics Corp., focused on developing towering index contrast optical waveguides for optical telecommunications. Bill served as the Director of Applications Engineering while at CPC and its partner, the MIT Lincoln Laboratory, developed silicon-on-insulator waveguide tapers for efficient laser source coupling to single mode photonic circuits.
He returned to PSI to pursue the progress and application of advanced optical sensors for pharmaceutical process monitoring and control. Bill is now the Vice President of the Applied Optics business enterprise within PSI and is the technical lead for the tunable diode laser absorption spectroscopy based LyoFlux® product. He oversees two additional business units, the Biomedical Optics Technology and Aerothermal System groups.
Contact information: [email protected], 978-738-8253
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Valley Cottage, NY -- (SBWIRE) -- 02/15/2019 -- A significant mount in the event of cardiovascular and ophthalmologic disorders has been recorded in recent years. As a countermeasure, condition authorities and private organisations in ophthalmic keeping are introducing several eye keeping programs for the general public. Globally, the number of people with eye disorders has increased to a austere level, hence further escalating the need for advanced eye keeping imaging and treatment. This has been observed as a major factor fuelling the exact for optical coherence tomography of late.
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A novel study conducted by Future Market Insights (FMI) reveals that the global optical coherence tomography market to grow from US$ 660.5 Mn in 2016 to US$ 1,349.1 Mn by 2027-end. This market is expected to expand at a CAGR of 6.7% in terms of revenue between 2017 and 2027. During this ten years of the forecast, the popularity of optical coherence tomography is expected to grow rapidly as medical companies are laying sturdy emphasis on progress of portable devices in order to extend the adoption rate of such imaging technology.
Global Optical Coherence Tomography Market: Opportunities and Trends
Manufacturers of OCT systems are actively focusing on expanding their existing orbit of products. Some of the latest OCT systems now approach with multi layers analysis of the surface as well as tender higher image resolutions. Moreover, making such systems portable and user-friendly is anticipated to embolden their robust adoption in the near future. Also, players in the global market for optical coherence tomography are expected to capitalize from increasing medical and non-medical application of OCT.
In an attempt to further improve their market position, some of the leading market players are entering into partnership, merger, sales agreement and acquisition with local manufacturers from emerging countries. FMI in its report titled "Optical Coherence Tomography Market: Global Industry Analysis and break Assessment, 2017–2027" has profiled leading market players such as Leica Microsystems (Sub. Danaher), Optovue Inc., Carl Zeiss Meditec AG, Santec Corporation, Heidelberg Engineering GmbH, OPTOPOL Technology Sp. z o.o. (Sub. Canon Inc.), Topcon Corporation, Michelson Diagnostics Ltd, Tomophase Inc., Moptim Imaging Technique, NIDEK CO., LTD., Sonostar Technologies Co., Limited.
Additional Highlights of the Report Include:
Preference for spectral domain-OCT is projected to remain relatively higher as compared to other types of OCT throughout the forecast period.
Application of OCT in ophthalmology is expected to bring in US$ 983.4 Mn in revenues towards the quit of 2027.
Based on quit users, hospitals are estimated to account for more than 39% market partake over the assessment period.
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Among regions, North America is expected to hold the largest partake of the market during the forecast period. By 2017-end, the region's market is expected to reach a valuation of US$ 232.2 Mn. Meanwhile, the OCT market in Asia-Pacific excluding Japan is expected to witness the highest growth over 2027. Owing to this, a number of leading market players such as Carl Zeiss Meditec AG, Topcon Corporation and Heidelberg Engineering GmbH are increasing their penetration in some of the key countries in the region, especially in China with their high-quality product types and services.
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San Francisco biotechnology company Prellis Biologics, has reported record speeds in tissue 3D printing using its holographic technology.
According to Dr. Melanie Matheu, co-founder and CEO of the company, “A major goal in tissue engineering is to create viable human organs, but nobody could print tissue with the hasten and resolution needed to configuration viable capillaries,”
“At Prellis, we’ve now developed that technology, paving the artery for essential medical advances and, ultimately, functional organ replacements.”
3D printing capillary structure using Prellis Biologics’ holographic technology. Image via Prellis Biologics
Holographic 3D bioprinting
3D printing at Prellis is performed by a laser-based process capable of curing liquid to solid in under less than 5 milliseconds of exposure time.
The technology is used to 3D print fine capillaries, that deliver nutrients to cells, and scaffolds, that assist uphold the growth of cells into a 3D tissue.
Instead of post-seeding the scaffolds and capillaries with cells, the live matter is actually mixed into the print material. To avoid any cell damage due to light exposure, Prellis uses a far-red laser light to cure the material.
“A kidney in 12 hours or less”
The key benefits of the Prellis process are that it 3D prints at a towering resolution, (producing feature sizes as minute as 0.5 microns) and towering speed, accounting for the rapid deterioration of live cells, which would die in less than 30 minutes without nutrients.
Dr. Matheu explains “The hasten they can achieve is limited only by the configuration of the optical system. They are now exploring custom optical system development, which will dramatically extend their capabilities,”
“Our ultimate goal is to print the entire vascular system of a kidney in 12 hours or less.”Prellis Biologics engineer studies 3D pritned tissue under a microscope. Photo via Bussiness Wire
Towards a fully 3D printed organ
The kidney has become a significant locality of interest in 3D bioprinting research. In particular, much pains has been placed in recreating the winding proximal tubules – the microscopic veins that consequence the groundwork of a kidney.
3D biomaterial company Organovo recently published a study demonstrating successful binding of kidney cells to consequence a proximal tubule.
And, at Harvard University, Professor Jennifer Lewis’ lab, led efforts to 3D print a proximal tubule “on-a-chip” that can exist used for drug testing.
Though insignificant in comparison to a entirely 3D printed organ, research at this stage is providing the building blocks for future breakthroughs noiseless to come.
A white paper assessing the advances and challenges of tissue engineering Have been summarized by Dr. Matheu, and Prellis Biologics’ principle optical engineers Erik Busby and John Borglin here.
Other towering hasten laser based 3D bioprinting technologies Have furthermore been explored before. At the University of California, Los Angeles (UCLA), researchers Have developed an SLA based 3D printer that builds multimaterial tissues on a chip.
For medical advances subscribe to the 3D Printing Industry newsletter, succeed us on Twitter, and dote us on Facebook.
Search and post 3D Printing Jobs here.
Featured image shows a microscopic 3D printed structure for encapsulating cells. Image via Prellis Biologics
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